ZP3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZP3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZP3 at tissue level.

III. Associated gene sets

GO_0007339Biological processbinding of sperm to zona pellucida
GO_0042102Biological processpositive regulation of T cell proliferation
GO_2000386Biological processpositive regulation of ovarian follicle development
GO_0032753Biological processpositive regulation of interleukin-4 production
GO_2000344Biological processpositive regulation of acrosome reaction
GO_0007165Biological processsignal transduction
GO_2000388Biological processpositive regulation of antral ovarian follicle growth
GO_0002922Biological processpositive regulation of humoral immune response
GO_0048599Biological processoocyte development
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0001809Biological processpositive regulation of type IV hypersensitivity
GO_2000360Biological processnegative regulation of binding of sperm to zona pellucida
GO_2000368Biological processpositive regulation of acrosomal vesicle exocytosis
GO_0002687Biological processpositive regulation of leukocyte migration
GO_0032729Biological processpositive regulation of type II interferon production
GO_0050729Biological processpositive regulation of inflammatory response
GO_0001825Biological processblastocyst formation
GO_0002455Biological processhumoral immune response mediated by circulating immunoglobulin
GO_0035803Biological processegg coat formation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0035805Cellular componentegg coat
GO_0031012Cellular componentextracellular matrix
GO_0048018Molecular functionreceptor ligand activity
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0035804Molecular functionstructural constituent of egg coat
GO_0030246Molecular functioncarbohydrate binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0032190Molecular functionacrosin binding

IV. Literature review

[source]
Gene nameZP3
Protein nameZona pellucida sperm-binding protein 3 (Zona pellucida glycoprotein 3) (Zona pellucida protein C)
Zona pellucida sperm-binding protein 3 (Sperm receptor) (ZP3A/ZP3B) (Zona pellucida glycoprotein 3) (Zp-3) (Zona pellucida protein C) [Cleaved into: Processed zona pellucida sperm-binding protein 3]
SynonymsZPC
ZP3A
ZP3B
DescriptionFUNCTION: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

FUNCTION: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. .

FUNCTION: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. .

AccessionsENST00000336517.8 [P21754-3]
ENST00000416245.5
E9PFI9
ENST00000394860.3
P21754
ENST00000394857.8 [P21754-1]
H0Y3M4