I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type II pneumocyte | 6 studies | 33% ± 10% | |
| astrocyte | 5 studies | 32% ± 18% | |
| epithelial cell | 4 studies | 38% ± 20% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| type II pneumocyte | 6 studies | 33% ± 10% | |
| astrocyte | 5 studies | 32% ± 18% | |
| epithelial cell | 4 studies | 38% ± 20% |
Insufficient scRNA-seq data for expression of FREM2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 2317.60 | 651 / 653 | 72% | 5.68 | 434 / 605 |
| kidney | 100% | 2201.69 | 89 / 89 | 70% | 6.44 | 635 / 901 |
| pancreas | 100% | 969.93 | 327 / 328 | 42% | 3.30 | 75 / 178 |
| stomach | 89% | 581.69 | 321 / 359 | 27% | 1.49 | 78 / 286 |
| lung | 68% | 690.33 | 392 / 578 | 48% | 5.27 | 559 / 1155 |
| prostate | 80% | 422.69 | 195 / 245 | 31% | 1.17 | 158 / 502 |
| brain | 57% | 160.41 | 1509 / 2642 | 49% | 4.48 | 348 / 705 |
| muscle | 90% | 780.63 | 725 / 803 | 0% | 0 | 0 / 0 |
| ovary | 82% | 285.48 | 148 / 180 | 6% | 0.42 | 27 / 430 |
| intestine | 56% | 262.55 | 540 / 966 | 24% | 1.15 | 124 / 527 |
| liver | 68% | 260.04 | 153 / 226 | 11% | 0.54 | 43 / 406 |
| skin | 31% | 77.80 | 555 / 1809 | 38% | 5.77 | 178 / 472 |
| bladder | 38% | 198.95 | 8 / 21 | 30% | 2.10 | 152 / 504 |
| breast | 35% | 71.45 | 162 / 459 | 21% | 1.67 | 240 / 1118 |
| uterus | 29% | 79.56 | 50 / 170 | 27% | 2.49 | 123 / 459 |
| esophagus | 3% | 6.31 | 37 / 1445 | 39% | 5.93 | 71 / 183 |
| adipose | 31% | 82.33 | 369 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 12% | 43.60 | 32 / 258 | 4% | 0.66 | 9 / 230 |
| tonsil | 0% | 0 | 0 / 0 | 7% | 0.34 | 3 / 45 |
| spleen | 6% | 13.38 | 15 / 241 | 0% | 0 | 0 / 0 |
| heart | 2% | 5.32 | 19 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 1% | 3.51 | 20 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.13 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007154 | Biological process | cell communication |
| GO_0042733 | Biological process | embryonic digit morphogenesis |
| GO_0001822 | Biological process | kidney development |
| GO_0048839 | Biological process | inner ear development |
| GO_0007155 | Biological process | cell adhesion |
| GO_0002009 | Biological process | morphogenesis of an epithelium |
| GO_0007507 | Biological process | heart development |
| GO_0001654 | Biological process | eye development |
| GO_0009653 | Biological process | anatomical structure morphogenesis |
| GO_0005604 | Cellular component | basement membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | FREM2 |
| Protein name | FRAS1-related extracellular matrix protein 2 (ECM3 homolog) |
| Synonyms | |
| Description | FUNCTION: Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia . Required for epidermal adhesion . Involved in the development of eyelids and the anterior segment of the eyeballs . . |
| Accessions | Q5SZK8 ENST00000280481.9 [Q5SZK8-1] |
