LTBP4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0017015Biological processregulation of transforming growth factor beta receptor signaling pathway
GO_0006457Biological processprotein folding
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0046879Biological processhormone secretion
GO_0001558Biological processregulation of cell growth
GO_0005615Cellular componentextracellular space
GO_0001527Cellular componentmicrofibril
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0050431Molecular functiontransforming growth factor beta binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0005539Molecular functionglycosaminoglycan binding
GO_0005024Molecular functiontransforming growth factor beta receptor activity
GO_0005178Molecular functionintegrin binding

IV. Literature review

[source]
Gene nameLTBP4
Protein nameLatent-transforming growth factor beta-binding protein 4 (LTBP-4)
Latent transforming growth factor beta binding protein 4
Synonyms
DescriptionFUNCTION: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. .

AccessionsM0QXV3
ENST00000599724.5
M0QYE9
A0A087WVV5
ENST00000622457.1
M0QZX0
ENST00000597071.5
A0A087WXC2
A0A087WYX7
ENST00000593463.5
ENST00000601032.5
ENST00000396819.8 [Q8N2S1-2]
Q8N2S1
A0A087WUU1
ENST00000594537.2
ENST00000598166.2
M0R351
ENST00000612121.4
ENST00000308370.11 [Q8N2S1-1]
A0A087X0A7
ENST00000243562.13
ENST00000599016.5
ENST00000618486.4
ENST00000599225.1
F8WAA0
A0A087WWZ7
ENST00000204005.13
A0A087WVR1
A0A0C4DH07
ENST00000600026.5
A0A087WXJ2