SPARC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0022604Biological processregulation of cell morphogenesis
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0016525Biological processnegative regulation of angiogenesis
GO_0001937Biological processnegative regulation of endothelial cell proliferation
GO_0048856Biological processanatomical structure development
GO_0005615Cellular componentextracellular space
GO_0031091Cellular componentplatelet alpha granule
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0071682Cellular componentendocytic vesicle lumen
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031092Cellular componentplatelet alpha granule membrane
GO_0016363Cellular componentnuclear matrix
GO_0009986Cellular componentcell surface
GO_0031093Cellular componentplatelet alpha granule lumen
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005604Cellular componentbasement membrane
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0050840Molecular functionextracellular matrix binding
GO_0005509Molecular functioncalcium ion binding
GO_0005518Molecular functioncollagen binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSPARC
Protein nameSecreted protein acidic and cysteine rich
Cysteine-rich protein
SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine)
SynonymsON
DescriptionFUNCTION: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.

AccessionsENST00000539687.6
ENST00000538026.5
ENST00000522348.1
E5RJA5
E5RK62
F5H4E2
Q6QE20
ENST00000521569.1
P09486
F5GY03
ENST00000231061.9