CSTB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	42 studies	66% ± 22%	Explore
endothelial cell	39 studies	45% ± 19%	Explore
fibroblast	36 studies	42% ± 15%	Explore
CD8-positive, alpha-beta T cell	36 studies	39% ± 15%	Explore
natural killer cell	35 studies	37% ± 12%	Explore
B cell	32 studies	30% ± 10%	Explore
T cell	30 studies	38% ± 13%	Explore
conventional dendritic cell	30 studies	71% ± 15%	Explore
CD4-positive, alpha-beta T cell	30 studies	40% ± 14%	Explore
pericyte	27 studies	35% ± 13%	Explore
dendritic cell	26 studies	61% ± 23%	Explore
classical monocyte	26 studies	63% ± 14%	Explore
regulatory T cell	26 studies	43% ± 17%	Explore
non-classical monocyte	24 studies	78% ± 14%	Explore
epithelial cell	24 studies	72% ± 22%	Explore
mast cell	23 studies	47% ± 17%	Explore
monocyte	22 studies	64% ± 16%	Explore
smooth muscle cell	22 studies	33% ± 10%	Explore
basal cell	22 studies	64% ± 22%	Explore
endothelial cell of lymphatic vessel	21 studies	65% ± 14%	Explore
mature NK T cell	20 studies	38% ± 13%	Explore
ciliated cell	19 studies	76% ± 19%	Explore
memory B cell	19 studies	27% ± 8%	Explore
connective tissue cell	18 studies	47% ± 17%	Explore
naive B cell	17 studies	26% ± 8%	Explore
gamma-delta T cell	17 studies	39% ± 14%	Explore
myeloid cell	16 studies	61% ± 26%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	34% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	34% ± 8%	Explore
plasma cell	13 studies	44% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	38% ± 14%	Explore
capillary endothelial cell	13 studies	42% ± 17%	Explore
myofibroblast cell	13 studies	37% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	39% ± 18%	Explore
secretory cell	12 studies	71% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	33% ± 11%	Explore
endothelial cell of artery	12 studies	41% ± 17%	Explore
endothelial cell of vascular tree	12 studies	49% ± 15%	Explore
plasmablast	11 studies	38% ± 19%	Explore
neutrophil	11 studies	43% ± 15%	Explore
plasmacytoid dendritic cell	11 studies	25% ± 7%	Explore
abnormal cell	11 studies	53% ± 20%	Explore
vein endothelial cell	11 studies	46% ± 17%	Explore
mucosal invariant T cell	11 studies	34% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	47% ± 20%	Explore
progenitor cell	10 studies	53% ± 17%	Explore
type I pneumocyte	9 studies	57% ± 17%	Explore
type II pneumocyte	9 studies	73% ± 26%	Explore
leukocyte	9 studies	48% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	38% ± 8%	Explore
goblet cell	9 studies	50% ± 24%	Explore
alveolar macrophage	8 studies	72% ± 27%	Explore
club cell	8 studies	74% ± 24%	Explore
astrocyte	8 studies	27% ± 13%	Explore
T follicular helper cell	8 studies	44% ± 11%	Explore
ionocyte	7 studies	73% ± 20%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	47% ± 13%	Explore
mononuclear phagocyte	7 studies	66% ± 16%	Explore
epithelial cell of proximal tubule	7 studies	45% ± 17%	Explore
enterocyte	7 studies	54% ± 16%	Explore
mesothelial cell	7 studies	34% ± 17%	Explore
innate lymphoid cell	7 studies	34% ± 18%	Explore
CD4-positive helper T cell	6 studies	32% ± 9%	Explore
hematopoietic precursor cell	6 studies	38% ± 17%	Explore
respiratory goblet cell	6 studies	74% ± 18%	Explore
kidney loop of Henle epithelial cell	6 studies	52% ± 12%	Explore
renal alpha-intercalated cell	6 studies	64% ± 11%	Explore
neuron	6 studies	34% ± 17%	Explore
intermediate monocyte	6 studies	71% ± 27%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	49% ± 21%	Explore
exhausted T cell	5 studies	57% ± 15%	Explore
monocyte-derived dendritic cell	5 studies	79% ± 14%	Explore
IgG plasma cell	5 studies	21% ± 8%	Explore
transit amplifying cell	5 studies	39% ± 13%	Explore
neuroendocrine cell	5 studies	73% ± 14%	Explore
T-helper 17 cell	5 studies	52% ± 16%	Explore
microglial cell	5 studies	44% ± 15%	Explore
inflammatory macrophage	5 studies	56% ± 18%	Explore
double negative thymocyte	5 studies	50% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	63% ± 19%	Explore
granulocyte	5 studies	46% ± 21%	Explore
hematopoietic stem cell	5 studies	31% ± 11%	Explore
melanocyte	5 studies	48% ± 24%	Explore
keratinocyte	5 studies	57% ± 15%	Explore
deuterosomal cell	4 studies	54% ± 18%	Explore
duct epithelial cell	4 studies	86% ± 8%	Explore
squamous epithelial cell	4 studies	72% ± 22%	Explore
pancreatic A cell	4 studies	72% ± 20%	Explore
type B pancreatic cell	4 studies	73% ± 19%	Explore
glomerular endothelial cell	4 studies	39% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	60% ± 8%	Explore
enteroendocrine cell	4 studies	65% ± 13%	Explore
retinal ganglion cell	4 studies	78% ± 21%	Explore
brush cell	4 studies	52% ± 22%	Explore
immature B cell	4 studies	39% ± 15%	Explore
amacrine cell	4 studies	36% ± 12%	Explore
retinal pigment epithelial cell	4 studies	52% ± 28%	Explore
adventitial cell	4 studies	49% ± 5%	Explore
mucus secreting cell	4 studies	56% ± 22%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	59% ± 8%	Explore
hepatocyte	4 studies	51% ± 26%	Explore
erythrocyte	4 studies	35% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	39% ± 7%	Explore
pancreatic D cell	3 studies	73% ± 23%	Explore
podocyte	3 studies	47% ± 6%	Explore
renal intercalated cell	3 studies	70% ± 6%	Explore
intestinal crypt stem cell	3 studies	46% ± 14%	Explore
neural crest cell	3 studies	26% ± 3%	Explore
IgA plasma cell	3 studies	23% ± 7%	Explore
retinal bipolar neuron	3 studies	38% ± 16%	Explore
renal principal cell	3 studies	63% ± 6%	Explore
extravillous trophoblast	3 studies	92% ± 3%	Explore
placental villous trophoblast	3 studies	70% ± 8%	Explore
lymphocyte	3 studies	55% ± 11%	Explore
precursor B cell	3 studies	36% ± 10%	Explore
retina horizontal cell	3 studies	35% ± 13%	Explore
retinal cone cell	3 studies	49% ± 17%	Explore
retinal rod cell	3 studies	36% ± 8%	Explore
serous secreting cell	3 studies	55% ± 17%	Explore
tissue-resident macrophage	3 studies	51% ± 23%	Explore
intraepithelial lymphocyte	3 studies	39% ± 6%	Explore
Mueller cell	3 studies	38% ± 9%	Explore
endothelial cell of sinusoid	3 studies	37% ± 17%	Explore
germinal center B cell	3 studies	49% ± 9%	Explore
luminal cell of prostate epithelium	3 studies	57% ± 10%	Explore
acinar cell	3 studies	44% ± 30%	Explore
pancreatic ductal cell	3 studies	77% ± 12%	Explore
oligodendrocyte precursor cell	3 studies	25% ± 3%	Explore
glial cell	3 studies	44% ± 16%	Explore
group 3 innate lymphoid cell	3 studies	39% ± 17%	Explore
T-helper 1 cell	3 studies	57% ± 14%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	43% ± 10%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	40% ± 13%	Explore
progenitor cell of mammary luminal epithelium	3 studies	58% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	56% ± 20%	Explore
peripheral blood	19 studies	42% ± 12%	Explore
intestine	14 studies	38% ± 16%	Explore
kidney	9 studies	45% ± 14%	Explore
eye	8 studies	33% ± 14%	Explore
brain	7 studies	34% ± 12%	Explore
lymph node	7 studies	39% ± 19%	Explore
liver	7 studies	41% ± 16%	Explore
uterus	6 studies	53% ± 20%	Explore
placenta	5 studies	53% ± 29%	Explore
pancreas	4 studies	70% ± 21%	Explore
bone marrow	4 studies	35% ± 17%	Explore
esophagus	4 studies	69% ± 27%	Explore
prostate	4 studies	47% ± 16%	Explore
breast	4 studies	48% ± 7%	Explore
ovary	3 studies	34% ± 10%	Explore
adrenal gland	3 studies	42% ± 7%	Explore
thymus	3 studies	47% ± 20%	Explore
skin	3 studies	55% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
uterus	100%	5578.14	170 / 170	100%	515.96	459 / 459
thymus	100%	5998.66	653 / 653	100%	176.91	602 / 605
skin	100%	8420.90	1809 / 1809	99%	263.94	467 / 472
intestine	100%	4803.32	965 / 966	99%	216.69	521 / 527
ovary	100%	4185.83	180 / 180	99%	150.40	424 / 430
lung	100%	9214.70	578 / 578	99%	322.01	1138 / 1155
bladder	100%	10156.86	21 / 21	98%	443.06	495 / 504
prostate	100%	5146.56	245 / 245	98%	100.69	492 / 502
breast	100%	6216.33	459 / 459	98%	153.11	1094 / 1118
esophagus	100%	142585.42	1444 / 1445	98%	446.86	179 / 183
stomach	99%	4063.08	355 / 359	98%	157.04	281 / 286
brain	100%	3903.34	2630 / 2642	95%	77.37	673 / 705
kidney	100%	5549.21	89 / 89	95%	117.08	854 / 901
adrenal gland	100%	6972.84	258 / 258	94%	90.99	216 / 230
liver	99%	5629.38	223 / 226	91%	103.94	369 / 406
pancreas	82%	1668.13	268 / 328	98%	231.43	175 / 178
adipose	100%	7195.27	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	199.99	80 / 80
lymph node	0%	0	0 / 0	100%	206.52	29 / 29
spleen	100%	4441.82	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	766.68	45 / 45
ureter	0%	0	0 / 0	100%	405.75	1 / 1
blood vessel	99%	4761.58	1327 / 1335	0%	0	0 / 0
peripheral blood	99%	5508.96	921 / 929	0%	0	0 / 0
heart	97%	3356.17	833 / 861	0%	0	0 / 0
muscle	93%	2176.42	744 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0008344	Biological process	adult locomotory behavior
GO_0045861	Biological process	negative regulation of proteolysis
GO_0010466	Biological process	negative regulation of peptidase activity
GO_0005730	Cellular component	nucleolus
GO_0005615	Cellular component	extracellular space
GO_0034774	Cellular component	secretory granule lumen
GO_0070062	Cellular component	extracellular exosome
GO_1904724	Cellular component	tertiary granule lumen
GO_0005829	Cellular component	cytosol
GO_1904813	Cellular component	ficolin-1-rich granule lumen
GO_0005576	Cellular component	extracellular region
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0002020	Molecular function	protease binding
GO_0004869	Molecular function	cysteine-type endopeptidase inhibitor activity
GO_0004866	Molecular function	endopeptidase inhibitor activity
GO_0003723	Molecular function	RNA binding

Gene name	CSTB
Protein name	Cystatin-B (CPI-B) (Liver thiol proteinase inhibitor) (Stefin-B) Cystatin-B (Stefin-B) Cystatin B
Synonyms	CST6 hCG_401291 STFB
Description	FUNCTION: This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. FUNCTION: This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. . FUNCTION: This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. .
Accessions	P04080 ENST00000639959.1 A0A1W2PQG6 ENST00000291568.7 ENST00000640406.1 Q76LA1 A0A1W2PS52

CSTB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review