CTSL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034230Biological processenkephalin processing
GO_0016540Biological processprotein autoprocessing
GO_0043373Biological processCD4-positive, alpha-beta T cell lineage commitment
GO_0097067Biological processcellular response to thyroid hormone stimulus
GO_0030574Biological processcollagen catabolic process
GO_0039654Biological processfusion of virus membrane with host endosome membrane
GO_0031638Biological processzymogen activation
GO_0048002Biological processantigen processing and presentation of peptide antigen
GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0046718Biological processsymbiont entry into host cell
GO_0071888Biological processmacrophage apoptotic process
GO_0019064Biological processfusion of virus membrane with host plasma membrane
GO_0006508Biological processproteolysis
GO_0019065Biological processreceptor-mediated endocytosis of virus by host cell
GO_0010952Biological processpositive regulation of peptidase activity
GO_0060309Biological processelastin catabolic process
GO_0019886Biological processantigen processing and presentation of exogenous peptide antigen via MHC class II
GO_0019882Biological processantigen processing and presentation
GO_0051603Biological processproteolysis involved in protein catabolic process
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0016324Cellular componentapical plasma membrane
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0071682Cellular componentendocytic vesicle lumen
GO_0005764Cellular componentlysosome
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0042583Cellular componentchromaffin granule
GO_0005771Cellular componentmultivesicular body
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0043202Cellular componentlysosomal lumen
GO_0036021Cellular componentendolysosome lumen
GO_0005634Cellular componentnucleus
GO_0042393Molecular functionhistone binding
GO_0008656Molecular functioncysteine-type endopeptidase activator activity involved in apoptotic process
GO_0097655Molecular functionserpin family protein binding
GO_0001968Molecular functionfibronectin binding
GO_0043394Molecular functionproteoglycan binding
GO_0008234Molecular functioncysteine-type peptidase activity
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005518Molecular functioncollagen binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCTSL
Protein nameCathepsin L
Cathepsin L, isoform CRA_b
Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain]
SynonymshCG_30369
CTSL1
DescriptionFUNCTION: Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells (By similarity). Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 . Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity). .; FUNCTION: (Microbial infection) In cells lacking TMPRSS2 expression, facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via a slow acid-activated route with the proteolysis of coronavirus spike (S) glycoproteins in lysosome for entry into host cell . Proteolysis within lysosomes is sufficient to activate membrane fusion by coronaviruses SARS-CoV and EMC (HCoV-EMC) S as well as Zaire ebolavirus glycoproteins . .; FUNCTION: [Isoform 2]: Functions in the regulation of cell cycle progression through proteolytic processing of the CUX1 transcription factor . Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and localize to the nucleus where they cleave the CUX1 transcription factor and modify its DNA binding properties . .

AccessionsENST00000678442.1 [P07711-1]
A0A7I2V2H7
A0A7I2V5M3
A0A7I2YQB5
ENST00000677523.1
ENST00000677638.1
ENST00000676480.1 [P07711-1]
ENST00000676531.1 [P07711-1]
ENST00000678596.1
ENST00000677864.1 [P07711-3]
ENST00000677955.1
A0A7I2V484
ENST00000678367.1
ENST00000677761.1 [P07711-1]
A0A7I2V5F7
A0A7I2YQA2
ENST00000677019.1 [P07711-3]
ENST00000678259.1
ENST00000340342.11 [P07711-1]
P07711
ENST00000679149.1 [P07711-1]
A0A7I2V601
ENST00000676946.1 [P07711-1]
Q9HBQ7
ENST00000342020.6
ENST00000677821.1 [P07711-1]
ENST00000679157.1 [P07711-1]
ENST00000679025.1
ENST00000676881.1 [P07711-1]
ENST00000679028.1
Q5T8F0
ENST00000677262.1 [P07711-1]
ENST00000678649.1
ENST00000676769.1 [P07711-3]
ENST00000343150.10 [P07711-1]
ENST00000679030.1
ENST00000678599.1