Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 16 studies | 53% ± 17% | |
endothelial cell of lymphatic vessel | 8 studies | 35% ± 20% | |
hepatocyte | 6 studies | 64% ± 25% | |
endothelial cell | 6 studies | 31% ± 13% | |
retina horizontal cell | 6 studies | 64% ± 29% | |
fibroblast | 5 studies | 32% ± 14% | |
cardiac muscle cell | 4 studies | 19% ± 2% | |
GABAergic neuron | 4 studies | 26% ± 8% | |
oligodendrocyte precursor cell | 4 studies | 21% ± 8% | |
cholangiocyte | 3 studies | 47% ± 25% | |
glutamatergic neuron | 3 studies | 24% ± 8% | |
astrocyte | 3 studies | 30% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
liver | 100% | 7251.36 | 226 / 226 | 89% | 12.55 | 363 / 406 |
stomach | 100% | 582.50 | 358 / 359 | 72% | 3.08 | 205 / 286 |
brain | 98% | 1591.17 | 2598 / 2642 | 65% | 5.53 | 461 / 705 |
esophagus | 98% | 576.34 | 1413 / 1445 | 63% | 2.79 | 116 / 183 |
breast | 90% | 401.16 | 412 / 459 | 70% | 6.86 | 783 / 1118 |
intestine | 78% | 591.17 | 756 / 966 | 70% | 2.90 | 368 / 527 |
lung | 95% | 432.07 | 550 / 578 | 47% | 1.87 | 547 / 1155 |
kidney | 80% | 243.87 | 71 / 89 | 55% | 9.54 | 492 / 901 |
prostate | 50% | 129.35 | 122 / 245 | 62% | 2.64 | 309 / 502 |
ovary | 94% | 564.34 | 170 / 180 | 14% | 0.63 | 62 / 430 |
bladder | 71% | 157.76 | 15 / 21 | 37% | 1.38 | 186 / 504 |
pancreas | 53% | 137.48 | 175 / 328 | 49% | 1.92 | 88 / 178 |
spleen | 100% | 5502.22 | 241 / 241 | 0% | 0 | 0 / 0 |
heart | 100% | 1262.02 | 857 / 861 | 0% | 0 | 0 / 0 |
muscle | 98% | 810.91 | 789 / 803 | 0% | 0 | 0 / 0 |
thymus | 83% | 262.97 | 541 / 653 | 13% | 2.89 | 78 / 605 |
skin | 73% | 714.65 | 1312 / 1809 | 22% | 1.32 | 103 / 472 |
adipose | 80% | 336.36 | 969 / 1204 | 0% | 0 | 0 / 0 |
adrenal gland | 62% | 212.91 | 160 / 258 | 18% | 1.59 | 42 / 230 |
uterus | 38% | 91.74 | 65 / 170 | 21% | 0.77 | 97 / 459 |
eye | 0% | 0 | 0 / 0 | 54% | 1.89 | 43 / 80 |
peripheral blood | 44% | 152.71 | 405 / 929 | 0% | 0 | 0 / 0 |
blood vessel | 30% | 109.88 | 406 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 24% | 0.66 | 11 / 45 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007354 | Biological process | zygotic determination of anterior/posterior axis, embryo |
GO_0034369 | Biological process | plasma lipoprotein particle remodeling |
GO_0007368 | Biological process | determination of left/right symmetry |
GO_0030510 | Biological process | regulation of BMP signaling pathway |
GO_0016486 | Biological process | peptide hormone processing |
GO_0016485 | Biological process | protein processing |
GO_0032940 | Biological process | secretion by cell |
GO_0009100 | Biological process | glycoprotein metabolic process |
GO_0032902 | Biological process | nerve growth factor production |
GO_0005615 | Cellular component | extracellular space |
GO_0005576 | Cellular component | extracellular region |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005796 | Cellular component | Golgi lumen |
GO_0062023 | Cellular component | collagen-containing extracellular matrix |
GO_0009986 | Cellular component | cell surface |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0008201 | Molecular function | heparin binding |
GO_0004175 | Molecular function | endopeptidase activity |
GO_0048406 | Molecular function | nerve growth factor binding |
GO_0005515 | Molecular function | protein binding |
GO_0004252 | Molecular function | serine-type endopeptidase activity |
Gene name | PCSK6 |
Protein name | Proprotein convertase subtilisin/kexin type 6 Alternative protein PCSK6 Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4) |
Synonyms | PACE4 |
Description | FUNCTION: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues. |
Accessions | ENST00000559605.1 H0YKK2 ENST00000611967.4 [P29122-4] A0A7I2V2Z7 ENST00000677528.1 H0YKZ4 H0Y3Q0 ENST00000677364.1 A0A7I2YQH5 L8EAN7 H0YLC8 ENST00000559417.2 ENST00000331826.12 A0A7I2V3T2 A2RQD9 ENST00000618548.4 [P29122-2] A0A087WZR0 A0A0J9YW51 ENST00000558864.5 ENST00000611716.5 [P29122-1] ENST00000558154.2 ENST00000678918.1 A0A7I2V3M4 ENST00000622483.4 H7BXT3 ENST00000619160.4 ENST00000615296.4 [P29122-5] H0YMW5 A0A087WY68 ENST00000632686.1 P29122 ENST00000398185.6 A0A0A8WJK9 ENST00000558951.5 |