PCSK6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007354Biological processzygotic determination of anterior/posterior axis, embryo
GO_0034369Biological processplasma lipoprotein particle remodeling
GO_0007368Biological processdetermination of left/right symmetry
GO_0030510Biological processregulation of BMP signaling pathway
GO_0016486Biological processpeptide hormone processing
GO_0016485Biological processprotein processing
GO_0032940Biological processsecretion by cell
GO_0009100Biological processglycoprotein metabolic process
GO_0032902Biological processnerve growth factor production
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005796Cellular componentGolgi lumen
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0009986Cellular componentcell surface
GO_0005783Cellular componentendoplasmic reticulum
GO_0008201Molecular functionheparin binding
GO_0004175Molecular functionendopeptidase activity
GO_0048406Molecular functionnerve growth factor binding
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene namePCSK6
Protein nameProprotein convertase subtilisin/kexin type 6
Alternative protein PCSK6
Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4)
SynonymsPACE4
DescriptionFUNCTION: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.

AccessionsENST00000559605.1
H0YKK2
ENST00000611967.4 [P29122-4]
A0A7I2V2Z7
ENST00000677528.1
H0YKZ4
H0Y3Q0
ENST00000677364.1
A0A7I2YQH5
L8EAN7
H0YLC8
ENST00000559417.2
ENST00000331826.12
A0A7I2V3T2
A2RQD9
ENST00000618548.4 [P29122-2]
A0A087WZR0
A0A0J9YW51
ENST00000558864.5
ENST00000611716.5 [P29122-1]
ENST00000558154.2
ENST00000678918.1
A0A7I2V3M4
ENST00000622483.4
H7BXT3
ENST00000619160.4
ENST00000615296.4 [P29122-5]
H0YMW5
A0A087WY68
ENST00000632686.1
P29122
ENST00000398185.6
A0A0A8WJK9
ENST00000558951.5