FGL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0070527Biological processplatelet aggregation
GO_0050868Biological processnegative regulation of T cell activation
GO_0050776Biological processregulation of immune response
GO_0072574Biological processhepatocyte proliferation
GO_0007160Biological processcell-matrix adhesion
GO_0005577Cellular componentfibrinogen complex
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFGL1
Protein nameFibrinogen-like protein 1 (HP-041) (Hepassocin) (HPS) (Hepatocyte-derived fibrinogen-related protein 1) (HFREP-1) (Liver fibrinogen-related protein 1) (LFIRE-1)
SynonymsHFREP1
DescriptionFUNCTION: Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 . Responsible for LAG3 T-cell inhibitory function . Binds LAG3 independently from MHC class II (MHC-II) . Secreted by, and promotes growth of, hepatocytes . .

AccessionsENST00000381841.4
Q08830
ENST00000381840.5
ENST00000522444.5
ENST00000518650.5
ENST00000427924.5
ENST00000398056.6
ENST00000398054.5