I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| myofibroblast cell | 4 studies | 34% ± 16% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| myofibroblast cell | 4 studies | 34% ± 16% |
Insufficient scRNA-seq data for expression of FGF18 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 96% | 195.92 | 628 / 653 | 46% | 2.04 | 280 / 605 |
| breast | 90% | 192.09 | 415 / 459 | 42% | 1.87 | 464 / 1118 |
| ovary | 32% | 26.13 | 58 / 180 | 98% | 56.42 | 422 / 430 |
| lung | 99% | 238.71 | 574 / 578 | 31% | 2.31 | 355 / 1155 |
| intestine | 65% | 61.82 | 631 / 966 | 56% | 3.34 | 296 / 527 |
| stomach | 51% | 43.40 | 184 / 359 | 60% | 3.55 | 173 / 286 |
| prostate | 89% | 113.60 | 219 / 245 | 18% | 0.62 | 88 / 502 |
| uterus | 75% | 65.66 | 127 / 170 | 30% | 7.25 | 138 / 459 |
| heart | 99% | 525.32 | 855 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 95% | 176.95 | 1274 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 94% | 261.79 | 1137 / 1204 | 0% | 0 | 0 / 0 |
| bladder | 67% | 72.86 | 14 / 21 | 22% | 1.48 | 112 / 504 |
| esophagus | 59% | 69.79 | 852 / 1445 | 30% | 1.77 | 54 / 183 |
| pancreas | 16% | 7.83 | 54 / 328 | 58% | 2.87 | 103 / 178 |
| spleen | 60% | 43.49 | 144 / 241 | 0% | 0 | 0 / 0 |
| skin | 49% | 77.63 | 888 / 1809 | 6% | 0.61 | 30 / 472 |
| kidney | 45% | 36.42 | 40 / 89 | 9% | 0.52 | 81 / 901 |
| brain | 43% | 26.77 | 1135 / 2642 | 4% | 0.20 | 25 / 705 |
| adrenal gland | 31% | 19.95 | 81 / 258 | 10% | 0.32 | 22 / 230 |
| muscle | 38% | 29.18 | 302 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 7% | 0.17 | 3 / 45 |
| liver | 3% | 1.13 | 7 / 226 | 3% | 0.15 | 14 / 406 |
| peripheral blood | 2% | 1.30 | 16 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0001525 | Biological process | angiogenesis |
| GO_2000546 | Biological process | positive regulation of endothelial cell chemotaxis to fibroblast growth factor |
| GO_0030324 | Biological process | lung development |
| GO_0008283 | Biological process | cell population proliferation |
| GO_0043536 | Biological process | positive regulation of blood vessel endothelial cell migration |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0009887 | Biological process | animal organ morphogenesis |
| GO_0007165 | Biological process | signal transduction |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0001957 | Biological process | intramembranous ossification |
| GO_0032332 | Biological process | positive regulation of chondrocyte differentiation |
| GO_1903670 | Biological process | regulation of sprouting angiogenesis |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0001958 | Biological process | endochondral ossification |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0002063 | Biological process | chondrocyte development |
| GO_0043406 | Biological process | positive regulation of MAP kinase activity |
| GO_0070371 | Biological process | ERK1 and ERK2 cascade |
| GO_0030154 | Biological process | cell differentiation |
| GO_0030334 | Biological process | regulation of cell migration |
| GO_0009653 | Biological process | anatomical structure morphogenesis |
| GO_0048010 | Biological process | vascular endothelial growth factor receptor signaling pathway |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0030949 | Biological process | positive regulation of vascular endothelial growth factor receptor signaling pathway |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0001936 | Biological process | regulation of endothelial cell proliferation |
| GO_0008543 | Biological process | fibroblast growth factor receptor signaling pathway |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0005105 | Molecular function | type 1 fibroblast growth factor receptor binding |
| GO_0005111 | Molecular function | type 2 fibroblast growth factor receptor binding |
| Gene name | FGF18 |
| Protein name | Fibroblast growth factor 18 (FGF-18) (zFGF5) |
| Synonyms | UNQ420/PRO856 |
| Description | FUNCTION: Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation. . |
| Accessions | ENST00000274625.6 O76093 |
