PAK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_2001238Biological processpositive regulation of extrinsic apoptotic signaling pathway
GO_0006469Biological processnegative regulation of protein kinase activity
GO_2001271Biological processnegative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO_0034333Biological processadherens junction assembly
GO_0051493Biological processregulation of cytoskeleton organization
GO_0007165Biological processsignal transduction
GO_0003300Biological processcardiac muscle hypertrophy
GO_0002223Biological processstimulatory C-type lectin receptor signaling pathway
GO_0035556Biological processintracellular signal transduction
GO_0060996Biological processdendritic spine development
GO_0043066Biological processnegative regulation of apoptotic process
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0070830Biological processbicellular tight junction assembly
GO_0006915Biological processapoptotic process
GO_0048010Biological processvascular endothelial growth factor receptor signaling pathway
GO_0016310Biological processphosphorylation
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0043408Biological processregulation of MAPK cascade
GO_0150105Biological processprotein localization to cell-cell junction
GO_0071407Biological processcellular response to organic cyclic compound
GO_0051497Biological processnegative regulation of stress fiber assembly
GO_0050770Biological processregulation of axonogenesis
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005911Cellular componentcell-cell junction
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0030141Cellular componentsecretory granule
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0045296Molecular functioncadherin binding
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0004672Molecular functionprotein kinase activity
GO_0030296Molecular functionprotein tyrosine kinase activator activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePAK2
Protein namep21 protein (Cdc42/Rac)-activated kinase 2
P21 (RAC1) activated kinase 2
Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]
Synonyms
DescriptionFUNCTION: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation . Acts as a downstream effector of the small GTPases CDC42 and RAC1 . Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues . Full-length PAK2 stimulates cell survival and cell growth . Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration . Phosphorylates JUN and plays an important role in EGF-induced cell proliferation . Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP . Phosphorylates CASP7, thereby preventing its activity . Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis . On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway . Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation . .

AccessionsH7C1X3
ENST00000327134.7
Q13177
H9XFB4
ENST00000426668.1