FLT4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FLT4 at tissue level.

III. Associated gene sets

GO_0060312Biological processregulation of blood vessel remodeling
GO_0001525Biological processangiogenesis
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0046330Biological processpositive regulation of JNK cascade
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0007275Biological processmulticellular organism development
GO_0001946Biological processlymphangiogenesis
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0038084Biological processvascular endothelial growth factor signaling pathway
GO_0002040Biological processsprouting angiogenesis
GO_0033674Biological processpositive regulation of kinase activity
GO_0001944Biological processvasculature development
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0030335Biological processpositive regulation of cell migration
GO_0003016Biological processrespiratory system process
GO_0010575Biological processpositive regulation of vascular endothelial growth factor production
GO_0090037Biological processpositive regulation of protein kinase C signaling
GO_0048010Biological processvascular endothelial growth factor receptor signaling pathway
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0048514Biological processblood vessel morphogenesis
GO_0043408Biological processregulation of MAPK cascade
GO_0001945Biological processlymph vessel development
GO_0046777Biological processprotein autophosphorylation
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0035924Biological processcellular response to vascular endothelial growth factor stimulus
GO_0048286Biological processlung alveolus development
GO_0043235Cellular componentreceptor complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0042803Molecular functionprotein homodimerization activity
GO_0005021Molecular functionvascular endothelial growth factor receptor activity
GO_0019903Molecular functionprotein phosphatase binding
GO_0004714Molecular functiontransmembrane receptor protein tyrosine kinase activity
GO_0019838Molecular functiongrowth factor binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFLT4
Protein nameFms related receptor tyrosine kinase 4 (Soluble VEGFR3 variant 2)
Vascular endothelial growth factor receptor 3 variant (EC 2.7.10.1)
Fms-related tyrosine kinase 4 (EC 2.7.10.1)
Alternative protein FLT4
Vascular endothelial growth factor receptor 3 (EC 2.7.10.1)
Vascular endothelial growth factor receptor 3
Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)
SynonymsVEGFR3
DescriptionFUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. .

AccessionsA0A0A7DZ98
A0A0A7DZ95
ENST00000512795.1
A0A0A7DZ60
I6ZMK4
A0A0H4A7R5
ENST00000393347.7 [P35916-1]
A0A0H4A774
A0A0A7DYC7
ENST00000502649.5
ENST00000619105.4
B5A927
A0A0A7DYE1
P35916
A0A0H4ADY2
A0A0A7DYA9
A0A0H4ABZ1
I6ZVY0
I6YRR9
A0A097NUS3
A0A0H4A771
ENST00000261937.11 [P35916-2]
A0A0H4AF71
E9PD35
D6RFF2
L8EBH4