I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 8 studies | 25% ± 7% | |
| pericyte | 4 studies | 23% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 8 studies | 25% ± 7% | |
| pericyte | 4 studies | 23% ± 3% |
Insufficient scRNA-seq data for expression of FOXC2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 98% | 546.55 | 87 / 89 | 70% | 8.85 | 634 / 901 |
| thymus | 78% | 216.21 | 508 / 653 | 57% | 1.29 | 346 / 605 |
| adrenal gland | 55% | 137.52 | 142 / 258 | 62% | 3.27 | 142 / 230 |
| breast | 57% | 172.90 | 261 / 459 | 57% | 2.87 | 636 / 1118 |
| lung | 65% | 195.54 | 376 / 578 | 36% | 1.51 | 418 / 1155 |
| blood vessel | 100% | 3614.19 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| esophagus | 17% | 40.75 | 244 / 1445 | 67% | 6.56 | 123 / 183 |
| heart | 82% | 303.17 | 705 / 861 | 0% | 0 | 0 / 0 |
| pancreas | 0% | 0.55 | 1 / 328 | 72% | 4.65 | 129 / 178 |
| uterus | 26% | 101.82 | 45 / 170 | 44% | 3.81 | 202 / 459 |
| adipose | 65% | 229.39 | 784 / 1204 | 0% | 0 | 0 / 0 |
| stomach | 6% | 15.44 | 23 / 359 | 52% | 2.10 | 150 / 286 |
| skin | 37% | 240.97 | 667 / 1809 | 17% | 1.13 | 80 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 49% | 2.07 | 22 / 45 |
| bladder | 19% | 43.90 | 4 / 21 | 25% | 1.60 | 128 / 504 |
| intestine | 8% | 17.05 | 77 / 966 | 35% | 1.54 | 183 / 527 |
| ovary | 24% | 92.39 | 44 / 180 | 14% | 0.38 | 61 / 430 |
| prostate | 25% | 71.13 | 61 / 245 | 13% | 0.23 | 67 / 502 |
| brain | 5% | 16.87 | 123 / 2642 | 23% | 0.63 | 165 / 705 |
| liver | 0% | 0.89 | 1 / 226 | 16% | 0.48 | 64 / 406 |
| eye | 0% | 0 | 0 / 0 | 8% | 0.08 | 6 / 80 |
| muscle | 4% | 10.18 | 35 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.05 | 1 / 29 |
| peripheral blood | 0% | 0.79 | 4 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0046620 | Biological process | regulation of organ growth |
| GO_0072144 | Biological process | glomerular mesangial cell development |
| GO_0007498 | Biological process | mesoderm development |
| GO_0033630 | Biological process | positive regulation of cell adhesion mediated by integrin |
| GO_0048844 | Biological process | artery morphogenesis |
| GO_0001657 | Biological process | ureteric bud development |
| GO_0001974 | Biological process | blood vessel remodeling |
| GO_0072112 | Biological process | podocyte differentiation |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0048343 | Biological process | paraxial mesodermal cell fate commitment |
| GO_0007507 | Biological process | heart development |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0001656 | Biological process | metanephros development |
| GO_0010595 | Biological process | positive regulation of endothelial cell migration |
| GO_0001946 | Biological process | lymphangiogenesis |
| GO_0072011 | Biological process | glomerular endothelium development |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0097746 | Biological process | blood vessel diameter maintenance |
| GO_0014032 | Biological process | neural crest cell development |
| GO_0055010 | Biological process | ventricular cardiac muscle tissue morphogenesis |
| GO_0003275 | Biological process | apoptotic process involved in outflow tract morphogenesis |
| GO_0035470 | Biological process | positive regulation of vascular wound healing |
| GO_0090050 | Biological process | positive regulation of cell migration involved in sprouting angiogenesis |
| GO_0060038 | Biological process | cardiac muscle cell proliferation |
| GO_0001569 | Biological process | branching involved in blood vessel morphogenesis |
| GO_0009725 | Biological process | response to hormone |
| GO_0008286 | Biological process | insulin receptor signaling pathway |
| GO_0048703 | Biological process | embryonic viscerocranium morphogenesis |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0030154 | Biological process | cell differentiation |
| GO_0035050 | Biological process | embryonic heart tube development |
| GO_0001756 | Biological process | somitogenesis |
| GO_0009653 | Biological process | anatomical structure morphogenesis |
| GO_0048010 | Biological process | vascular endothelial growth factor receptor signaling pathway |
| GO_0043010 | Biological process | camera-type eye development |
| GO_0030199 | Biological process | collagen fibril organization |
| GO_0001503 | Biological process | ossification |
| GO_1902257 | Biological process | negative regulation of apoptotic process involved in outflow tract morphogenesis |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0120163 | Biological process | negative regulation of cold-induced thermogenesis |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0016604 | Cellular component | nuclear body |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_1990841 | Molecular function | promoter-specific chromatin binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0001216 | Molecular function | DNA-binding transcription activator activity |
| GO_0031490 | Molecular function | chromatin DNA binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | FOXC2 |
| Protein name | Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) Forkhead box C2 Truncated forkhead box C2 |
| Synonyms | MFH1 FKHL14 |
| Description | FUNCTION: Transcriptional activator. . |
| Accessions | Q99958 I6ZVX6 I6Z262 I6YRR3 I6ZZT5 I6ZZU0 I6ZMK0 ENST00000649859.1 |
