GATA2 | OmnibusX

Name	Number of supported studies	Average coverage
mast cell	32 studies	65% ± 20%	Explore
endothelial cell of artery	10 studies	24% ± 6%	Explore
endothelial cell	7 studies	31% ± 10%	Explore
capillary endothelial cell	7 studies	28% ± 6%	Explore
hematopoietic stem cell	4 studies	30% ± 6%	Explore
granulocyte	4 studies	69% ± 7%	Explore
extravillous trophoblast	3 studies	44% ± 9%	Explore
endothelial cell of vascular tree	3 studies	17% ± 1%	Explore
fibroblast	3 studies	23% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	68% ± 9%	Explore
erythroblast	3 studies	19% ± 3%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GATA2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	9752.45	245 / 245	100%	125.89	502 / 502
uterus	100%	7862.40	170 / 170	73%	16.61	333 / 459
bladder	100%	5282.90	21 / 21	70%	29.69	352 / 504
breast	100%	2154.78	458 / 459	61%	13.46	685 / 1118
lung	100%	6130.91	578 / 578	59%	7.21	682 / 1155
kidney	100%	2747.81	89 / 89	58%	10.69	523 / 901
pancreas	100%	1204.48	328 / 328	57%	6.36	102 / 178
adrenal gland	66%	585.32	171 / 258	70%	95.75	160 / 230
intestine	96%	1102.34	929 / 966	34%	2.91	181 / 527
thymus	99%	1288.31	645 / 653	30%	2.58	179 / 605
stomach	96%	877.49	346 / 359	29%	2.45	82 / 286
esophagus	96%	1398.14	1388 / 1445	27%	2.63	49 / 183
skin	93%	1163.77	1683 / 1809	21%	1.92	99 / 472
spleen	100%	1989.48	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	194.90	1 / 1
adipose	100%	2512.82	1203 / 1204	0%	0	0 / 0
heart	100%	1422.47	859 / 861	0%	0	0 / 0
brain	41%	214.09	1088 / 2642	44%	4.81	311 / 705
ovary	62%	622.51	112 / 180	22%	5.04	95 / 430
muscle	83%	541.54	664 / 803	0%	0	0 / 0
blood vessel	81%	818.09	1085 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	18%	2.16	8 / 45
peripheral blood	16%	89.92	147 / 929	0%	0	0 / 0
liver	3%	11.92	6 / 226	8%	0.79	34 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043306	Biological process	positive regulation of mast cell degranulation
GO_0002071	Biological process	glandular epithelial cell maturation
GO_0006366	Biological process	transcription by RNA polymerase II
GO_0002244	Biological process	hematopoietic progenitor cell differentiation
GO_0050766	Biological process	positive regulation of phagocytosis
GO_0050873	Biological process	brown fat cell differentiation
GO_2000352	Biological process	negative regulation of endothelial cell apoptotic process
GO_0045654	Biological process	positive regulation of megakaryocyte differentiation
GO_0001709	Biological process	cell fate determination
GO_0010629	Biological process	negative regulation of gene expression
GO_0043536	Biological process	positive regulation of blood vessel endothelial cell migration
GO_0001655	Biological process	urogenital system development
GO_0001892	Biological process	embryonic placenta development
GO_0045766	Biological process	positive regulation of angiogenesis
GO_1901533	Biological process	negative regulation of hematopoietic progenitor cell differentiation
GO_0010628	Biological process	positive regulation of gene expression
GO_0060872	Biological process	semicircular canal development
GO_0001764	Biological process	neuron migration
GO_0010725	Biological process	regulation of primitive erythrocyte differentiation
GO_0097154	Biological process	GABAergic neuron differentiation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0021902	Biological process	commitment of neuronal cell to specific neuron type in forebrain
GO_0035854	Biological process	eosinophil fate commitment
GO_0061484	Biological process	hematopoietic stem cell homeostasis
GO_0048873	Biological process	homeostasis of number of cells within a tissue
GO_0090050	Biological process	positive regulation of cell migration involved in sprouting angiogenesis
GO_0060216	Biological process	definitive hemopoiesis
GO_0021533	Biological process	cell differentiation in hindbrain
GO_0045650	Biological process	negative regulation of macrophage differentiation
GO_0042551	Biological process	neuron maturation
GO_0033993	Biological process	response to lipid
GO_0045165	Biological process	cell fate commitment
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0090102	Biological process	cochlea development
GO_0060129	Biological process	thyroid-stimulating hormone-secreting cell differentiation
GO_1902895	Biological process	positive regulation of miRNA transcription
GO_2000977	Biological process	regulation of forebrain neuron differentiation
GO_0021514	Biological process	ventral spinal cord interneuron differentiation
GO_0021954	Biological process	central nervous system neuron development
GO_0006909	Biological process	phagocytosis
GO_0045648	Biological process	positive regulation of erythrocyte differentiation
GO_0042472	Biological process	inner ear morphogenesis
GO_0007406	Biological process	negative regulation of neuroblast proliferation
GO_0061042	Biological process	vascular wound healing
GO_0045666	Biological process	positive regulation of neuron differentiation
GO_0060100	Biological process	positive regulation of phagocytosis, engulfment
GO_1903444	Biological process	negative regulation of brown fat cell differentiation
GO_0045746	Biological process	negative regulation of Notch signaling pathway
GO_0035019	Biological process	somatic stem cell population maintenance
GO_1903589	Biological process	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO_2000178	Biological process	negative regulation of neural precursor cell proliferation
GO_0045444	Biological process	fat cell differentiation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0007405	Biological process	neuroblast proliferation
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0005667	Cellular component	transcription regulator complex
GO_0005634	Cellular component	nucleus
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682	Molecular function	chromatin binding
GO_0001221	Molecular function	transcription coregulator binding
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0001223	Molecular function	transcription coactivator binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0008270	Molecular function	zinc ion binding
GO_0070742	Molecular function	C2H2 zinc finger domain binding
GO_0005515	Molecular function	protein binding

Gene name	GATA2
Protein name	GATA binding protein 2 Endothelial transcription factor GATA-2 (GATA-binding protein 2)
Synonyms
Description	FUNCTION: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.
Accessions	ENST00000498200.1 A0A8Q3WMC3 C9J965 A0A8Q3SJG7 A0A8Q3WLD0 ENST00000696654.1 ENST00000487848.6 [P23769-1] ENST00000696672.1 A0A1D5RMQ8 ENST00000696653.1 ENST00000430265.6 [P23769-2] ENST00000696466.1 ENST00000696661.1 ENST00000492608.1 ENST00000696652.1 P23769 ENST00000341105.7 [P23769-1]

GATA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review