SH3GL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016191Biological processsynaptic vesicle uncoating
GO_0010629Biological processnegative regulation of gene expression
GO_1990416Biological processcellular response to brain-derived neurotrophic factor stimulus
GO_0097484Biological processdendrite extension
GO_0031175Biological processneuron projection development
GO_0007165Biological processsignal transduction
GO_1905604Biological processnegative regulation of blood-brain barrier permeability
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0007417Biological processcentral nervous system development
GO_0098978Cellular componentglutamatergic synapse
GO_0098793Cellular componentpresynapse
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005769Cellular componentearly endosome
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0042995Cellular componentcell projection
GO_0008289Molecular functionlipid binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSH3GL2
Protein nameEndophilin
Endophilin A1 BAR domain
Mutated endophilin A1 BAR domain
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
SH3GL2 protein
SynonymsCNSA2
SH3D2A
DescriptionFUNCTION: Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. .

AccessionsQ8IZ09
ENST00000380607.5
A7LBA6
Q3V639
Q3V638
Q99962