Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 7 studies | 30% ± 8% | |
fibroblast | 6 studies | 21% ± 7% | |
epithelial cell | 5 studies | 42% ± 18% | |
oligodendrocyte | 5 studies | 25% ± 6% | |
B cell | 4 studies | 26% ± 5% | |
classical monocyte | 4 studies | 22% ± 7% | |
basal cell | 4 studies | 25% ± 14% | |
retina horizontal cell | 4 studies | 19% ± 4% | |
ciliated cell | 4 studies | 31% ± 13% | |
macrophage | 4 studies | 21% ± 4% | |
astrocyte | 4 studies | 26% ± 5% | |
plasmacytoid dendritic cell | 4 studies | 21% ± 4% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 17% ± 1% | |
CD4-positive, alpha-beta T cell | 3 studies | 19% ± 2% | |
conventional dendritic cell | 3 studies | 27% ± 11% | |
hematopoietic precursor cell | 3 studies | 29% ± 9% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 3 studies | 17% ± 2% | |
connective tissue cell | 3 studies | 24% ± 5% | |
naive B cell | 3 studies | 17% ± 2% | |
GABAergic neuron | 3 studies | 42% ± 4% | |
glutamatergic neuron | 3 studies | 54% ± 4% | |
oligodendrocyte precursor cell | 3 studies | 26% ± 5% | |
dendritic cell | 3 studies | 31% ± 12% | |
enteroendocrine cell | 3 studies | 25% ± 10% | |
goblet cell | 3 studies | 26% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 10881.54 | 1445 / 1445 | 100% | 48.62 | 183 / 183 |
intestine | 100% | 11824.62 | 966 / 966 | 100% | 49.01 | 527 / 527 |
liver | 100% | 7054.06 | 226 / 226 | 100% | 32.29 | 406 / 406 |
ovary | 100% | 12650.33 | 180 / 180 | 100% | 39.18 | 430 / 430 |
stomach | 100% | 8222.03 | 359 / 359 | 100% | 42.80 | 286 / 286 |
uterus | 100% | 12950.85 | 170 / 170 | 100% | 69.35 | 459 / 459 |
brain | 100% | 8829.70 | 2639 / 2642 | 100% | 51.83 | 705 / 705 |
thymus | 100% | 13100.93 | 653 / 653 | 100% | 52.53 | 604 / 605 |
bladder | 100% | 10940.24 | 21 / 21 | 100% | 54.60 | 503 / 504 |
prostate | 100% | 11984.42 | 245 / 245 | 100% | 53.99 | 501 / 502 |
lung | 100% | 11248.66 | 578 / 578 | 100% | 47.78 | 1152 / 1155 |
pancreas | 100% | 5634.98 | 327 / 328 | 100% | 46.20 | 178 / 178 |
kidney | 100% | 8857.40 | 89 / 89 | 100% | 36.55 | 898 / 901 |
skin | 100% | 11452.25 | 1809 / 1809 | 100% | 49.59 | 470 / 472 |
breast | 100% | 10976.67 | 459 / 459 | 99% | 59.08 | 1112 / 1118 |
adrenal gland | 100% | 8770.05 | 258 / 258 | 99% | 35.18 | 227 / 230 |
adipose | 100% | 9863.35 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 11160.61 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 70.14 | 29 / 29 |
muscle | 100% | 9109.14 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 11881.45 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 60.05 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 36.17 | 1 / 1 |
heart | 99% | 6766.84 | 851 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 33.94 | 78 / 80 |
peripheral blood | 82% | 5133.43 | 758 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0010468 | Biological process | regulation of gene expression |
GO_0006397 | Biological process | mRNA processing |
GO_0010629 | Biological process | negative regulation of gene expression |
GO_0034976 | Biological process | response to endoplasmic reticulum stress |
GO_0043922 | Biological process | negative regulation by host of viral transcription |
GO_0042307 | Biological process | positive regulation of protein import into nucleus |
GO_0071765 | Biological process | nuclear inner membrane organization |
GO_0061158 | Biological process | 3'-UTR-mediated mRNA destabilization |
GO_0032024 | Biological process | positive regulation of insulin secretion |
GO_0042752 | Biological process | regulation of circadian rhythm |
GO_0001933 | Biological process | negative regulation of protein phosphorylation |
GO_1990000 | Biological process | amyloid fibril formation |
GO_0042981 | Biological process | regulation of apoptotic process |
GO_0008380 | Biological process | RNA splicing |
GO_0070935 | Biological process | 3'-UTR-mediated mRNA stabilization |
GO_0048511 | Biological process | rhythmic process |
GO_0051726 | Biological process | regulation of cell cycle |
GO_0031647 | Biological process | regulation of protein stability |
GO_0005726 | Cellular component | perichromatin fibrils |
GO_0005739 | Cellular component | mitochondrion |
GO_0016607 | Cellular component | nuclear speck |
GO_0005654 | Cellular component | nucleoplasm |
GO_0043232 | Cellular component | intracellular non-membrane-bounded organelle |
GO_0035061 | Cellular component | interchromatin granule |
GO_0000785 | Cellular component | chromatin |
GO_0010494 | Cellular component | cytoplasmic stress granule |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0008289 | Molecular function | lipid binding |
GO_0097157 | Molecular function | pre-mRNA intronic binding |
GO_0003690 | Molecular function | double-stranded DNA binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0140693 | Molecular function | molecular condensate scaffold activity |
GO_0003723 | Molecular function | RNA binding |
GO_0003730 | Molecular function | mRNA 3'-UTR binding |
GO_0005515 | Molecular function | protein binding |
Gene name | TARDBP |
Protein name | TAR DNA binding protein (TDP43 isoform F) TAR DNA-binding protein 43 (TDP-43) TAR DNA binding protein (TDP43 isoform I) TAR DNA binding protein TAR DNA-binding protein 43 TAR DNA binding protein, isoform CRA_c |
Synonyms | TDP43 hCG_2005583 |
Description | FUNCTION: RNA-binding protein that is involved in various steps of RNA biogenesis and processing . Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs . In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases . Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts . Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening . In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival . Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins . Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner . Negatively regulates the expression of CDK6 . Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner . . |
Accessions | ENST00000621715.4 ENST00000612542.1 A0A087WXQ5 ENST00000476201.5 A0A0A0MSV7 A0A087WTZ4 ENST00000472476.5 ENST00000473118.5 ENST00000611963.4 ENST00000621790.4 K7EN94 ENST00000639599.1 ENST00000649624.1 K7EJ99 A0A087WX67 ENST00000620632.4 A0A087WYE7 K7ENM9 ENST00000621573.1 A0A087X260 A0A087WZM1 K7EL26 ENST00000315091.7 ENST00000240185.8 [Q13148-1] A0A087WVX6 ENST00000620505.1 ENST00000622057.4 A0A0A0N0M3 ENST00000614757.4 A0A087WXV3 Q13148 A0A087WZC9 ENST00000439080.6 ENST00000619555.4 ENST00000473869.5 ENST00000496840.1 A0A087WV68 ENST00000629725.2 ENST00000622108.1 Q9H256 A0A087WW61 K7EJM5 A0A087WX29 ENST00000611136.4 ENST00000614494.1 A0A087WTG4 ENST00000639083.1 [Q13148-1] A0A087WYY0 ENST00000616545.4 ENST00000477447.6 ENST00000610369.4 ENST00000617172.4 G3V162 B1AKP7 |