TARDBP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010468Biological processregulation of gene expression
GO_0006397Biological processmRNA processing
GO_0010629Biological processnegative regulation of gene expression
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0043922Biological processnegative regulation by host of viral transcription
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0071765Biological processnuclear inner membrane organization
GO_0061158Biological process3'-UTR-mediated mRNA destabilization
GO_0032024Biological processpositive regulation of insulin secretion
GO_0042752Biological processregulation of circadian rhythm
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_1990000Biological processamyloid fibril formation
GO_0042981Biological processregulation of apoptotic process
GO_0008380Biological processRNA splicing
GO_0070935Biological process3'-UTR-mediated mRNA stabilization
GO_0048511Biological processrhythmic process
GO_0051726Biological processregulation of cell cycle
GO_0031647Biological processregulation of protein stability
GO_0005726Cellular componentperichromatin fibrils
GO_0005739Cellular componentmitochondrion
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0043232Cellular componentintracellular non-membrane-bounded organelle
GO_0035061Cellular componentinterchromatin granule
GO_0000785Cellular componentchromatin
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0008289Molecular functionlipid binding
GO_0097157Molecular functionpre-mRNA intronic binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0003723Molecular functionRNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTARDBP
Protein nameTAR DNA binding protein (TDP43 isoform F)
TAR DNA-binding protein 43 (TDP-43)
TAR DNA binding protein (TDP43 isoform I)
TAR DNA binding protein
TAR DNA-binding protein 43
TAR DNA binding protein, isoform CRA_c
SynonymsTDP43
hCG_2005583
DescriptionFUNCTION: RNA-binding protein that is involved in various steps of RNA biogenesis and processing . Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs . In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases . Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts . Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening . In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival . Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins . Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner . Negatively regulates the expression of CDK6 . Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner . .

AccessionsENST00000621715.4
ENST00000612542.1
A0A087WXQ5
ENST00000476201.5
A0A0A0MSV7
A0A087WTZ4
ENST00000472476.5
ENST00000473118.5
ENST00000611963.4
ENST00000621790.4
K7EN94
ENST00000639599.1
ENST00000649624.1
K7EJ99
A0A087WX67
ENST00000620632.4
A0A087WYE7
K7ENM9
ENST00000621573.1
A0A087X260
A0A087WZM1
K7EL26
ENST00000315091.7
ENST00000240185.8 [Q13148-1]
A0A087WVX6
ENST00000620505.1
ENST00000622057.4
A0A0A0N0M3
ENST00000614757.4
A0A087WXV3
Q13148
A0A087WZC9
ENST00000439080.6
ENST00000619555.4
ENST00000473869.5
ENST00000496840.1
A0A087WV68
ENST00000629725.2
ENST00000622108.1
Q9H256
A0A087WW61
K7EJM5
A0A087WX29
ENST00000611136.4
ENST00000614494.1
A0A087WTG4
ENST00000639083.1 [Q13148-1]
A0A087WYY0
ENST00000616545.4
ENST00000477447.6
ENST00000610369.4
ENST00000617172.4
G3V162
B1AKP7