NR0B2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NR0B2 at tissue level.

III. Associated gene sets

GO_0007219Biological processNotch signaling pathway
GO_0009749Biological processresponse to glucose
GO_0010629Biological processnegative regulation of gene expression
GO_0010628Biological processpositive regulation of gene expression
GO_0008203Biological processcholesterol metabolic process
GO_0014070Biological processresponse to organic cyclic compound
GO_0031100Biological processanimal organ regeneration
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045471Biological processresponse to ethanol
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0032024Biological processpositive regulation of insulin secretion
GO_0032922Biological processcircadian regulation of gene expression
GO_0007623Biological processcircadian rhythm
GO_0015721Biological processbile acid and bile salt transport
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0046966Molecular functionnuclear thyroid hormone receptor binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0019904Molecular functionprotein domain specific binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0140416Molecular functiontranscription regulator inhibitor activity
GO_0003714Molecular functiontranscription corepressor activity
GO_0046965Molecular functionnuclear retinoid X receptor binding
GO_0042975Molecular functionperoxisome proliferator activated receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNR0B2
Protein nameNuclear receptor subfamily 0 group B member 2 (Orphan nuclear receptor SHP) (Small heterodimer partner)
SynonymsSHP
DescriptionFUNCTION: Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (By similarity). Specifically inhibits transactivation of the nuclear receptor with which it interacts (By similarity). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 . Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity). .

AccessionsENST00000254227.4
Q15466