I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 3 studies | 31% ± 11% | |
| glutamatergic neuron | 3 studies | 37% ± 13% | |
| astrocyte | 3 studies | 17% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 3 studies | 31% ± 11% | |
| glutamatergic neuron | 3 studies | 37% ± 13% | |
| astrocyte | 3 studies | 17% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 26% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 3362.61 | 2642 / 2642 | 99% | 15.40 | 696 / 705 |
| liver | 48% | 261.58 | 108 / 226 | 42% | 1.39 | 169 / 406 |
| adrenal gland | 9% | 52.70 | 22 / 258 | 65% | 7.92 | 149 / 230 |
| kidney | 10% | 52.18 | 9 / 89 | 29% | 0.71 | 259 / 901 |
| intestine | 3% | 14.25 | 31 / 966 | 28% | 0.70 | 150 / 527 |
| stomach | 0% | 1.19 | 1 / 359 | 26% | 0.67 | 75 / 286 |
| lymph node | 0% | 0 | 0 / 0 | 24% | 0.64 | 7 / 29 |
| pancreas | 0% | 0 | 0 / 328 | 15% | 0.54 | 27 / 178 |
| esophagus | 0% | 0 | 0 / 1445 | 12% | 0.84 | 22 / 183 |
| lung | 0% | 0 | 0 / 578 | 8% | 0.24 | 97 / 1155 |
| bladder | 0% | 0 | 0 / 21 | 8% | 0.18 | 40 / 504 |
| ovary | 0% | 0 | 0 / 180 | 8% | 0.17 | 33 / 430 |
| uterus | 0% | 0 | 0 / 170 | 7% | 0.22 | 33 / 459 |
| breast | 0% | 0 | 0 / 459 | 5% | 0.11 | 57 / 1118 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.08 | 2 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.03 | 1 / 45 |
| prostate | 1% | 3.84 | 3 / 245 | 0% | 0.01 | 1 / 502 |
| thymus | 0% | 0.45 | 1 / 653 | 1% | 0.03 | 7 / 605 |
| skin | 0% | 0.36 | 2 / 1809 | 1% | 0.02 | 3 / 472 |
| peripheral blood | 0% | 0.72 | 2 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0.22 | 1 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0 | 0 / 1204 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0018105 | Biological process | peptidyl-serine phosphorylation |
| GO_1903980 | Biological process | positive regulation of microglial cell activation |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0007611 | Biological process | learning or memory |
| GO_0007165 | Biological process | signal transduction |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0018107 | Biological process | peptidyl-threonine phosphorylation |
| GO_0018108 | Biological process | peptidyl-tyrosine phosphorylation |
| GO_2001056 | Biological process | positive regulation of cysteine-type endopeptidase activity |
| GO_1904031 | Biological process | positive regulation of cyclin-dependent protein kinase activity |
| GO_0021762 | Biological process | substantia nigra development |
| GO_0032273 | Biological process | positive regulation of protein polymerization |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0032091 | Biological process | negative regulation of protein binding |
| GO_0061890 | Biological process | positive regulation of astrocyte activation |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005875 | Cellular component | microtubule associated complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0004713 | Molecular function | protein tyrosine kinase activity |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0050321 | Molecular function | tau-protein kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0048156 | Molecular function | tau protein binding |
| Gene name | TTBK1 |
| Protein name | Tau tubulin kinase 1 Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase) Alternative protein TTBK1 |
| Synonyms | KIAA1855 BDTK |
| Description | FUNCTION: Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU. . |
| Accessions | Q5TCY1 ENST00000703836.1 L8E9F5 A0A994J709 ENST00000259750.9 [Q5TCY1-1] |
