TAF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_2000059Biological processnegative regulation of ubiquitin-dependent protein catabolic process
GO_0000209Biological processprotein polyubiquitination
GO_0010629Biological processnegative regulation of gene expression
GO_0006361Biological processtranscription initiation at RNA polymerase I promoter
GO_0034644Biological processcellular response to UV
GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0032092Biological processpositive regulation of protein binding
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006974Biological processDNA damage response
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_1902806Biological processregulation of cell cycle G1/S phase transition
GO_1905524Biological processnegative regulation of protein autoubiquitination
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0071318Biological processcellular response to ATP
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0050821Biological processprotein stabilization
GO_2000825Biological processpositive regulation of androgen receptor activity
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0030901Biological processmidbrain development
GO_0005730Cellular componentnucleolus
GO_0071339Cellular componentMLL1 complex
GO_0005669Cellular componenttranscription factor TFIID complex
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0001181Molecular functionRNA polymerase I general transcription initiation factor activity
GO_0017025Molecular functionTBP-class protein binding
GO_0016922Molecular functionnuclear receptor binding
GO_0001091Molecular functionRNA polymerase II general transcription initiation factor binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0043565Molecular functionsequence-specific DNA binding
GO_1905502Molecular functionacetyl-CoA binding
GO_0070577Molecular functionlysine-acetylated histone binding
GO_0140416Molecular functiontranscription regulator inhibitor activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0061628Molecular functionH3K27me3 modified histone binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0002039Molecular functionp53 binding
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0004402Molecular functionhistone acetyltransferase activity
GO_0016251Molecular functionRNA polymerase II general transcription initiation factor activity
GO_0061631Molecular functionubiquitin conjugating enzyme activity
GO_0005515Molecular functionprotein binding
GO_0000979Molecular functionRNA polymerase II core promoter sequence-specific DNA binding

IV. Literature review

[source]
Gene nameTAF1
Protein nameTATA-box binding protein associated factor 1
Alternative protein TAF1
Transcription initiation factor TFIID subunit
Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)
SynonymsBA2R
TAF2A
CCGS
CCG1
DescriptionFUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription . TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) . The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 . TAF1 is the largest component and core scaffold of the TFIID complex, involved in nucleating complex assembly . TAF1 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF2 . Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors . Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53 . Phosphorylates GTF2A1 and GTF2F1 on Ser residues . Possesses DNA-binding activity . Essential for progression of the G1 phase of the cell cycle . Exhibits histone acetyltransferase activity towards histones H3 and H4 . .

AccessionsENST00000461764.6
L8EAA9
A0A804HK00
ENST00000373775.8
ENST00000483985.3
ENST00000683715.1
A0A804HHS0
ENST00000683782.1
H0Y8N6
ENST00000683954.1
A0A804HIY8
ENST00000682124.1
A0A804HK58
H0Y9L7
H7BY98
A0AA75HR15
ENST00000683358.1
A0A804HJ48
ENST00000373790.9 [P21675-13]
P21675
ENST00000485087.6
A0A804HJT5
ENST00000683668.1
ENST00000276072.9
A0A804HLH3
ENST00000423759.6 [P21675-14]
ENST00000683202.1
ENST00000437147.8
ENST00000463163.5
ENST00000462588.5
A0A804HIC2
H7C2K9
ENST00000467309.5
A0A804HJ34
A0A804HJE0