Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 14 studies | 28% ± 11% | |
| astrocyte | 11 studies | 30% ± 11% | |
| microglial cell | 10 studies | 29% ± 9% | |
| macrophage | 10 studies | 31% ± 14% | |
| myeloid cell | 9 studies | 28% ± 9% | |
| epithelial cell | 9 studies | 33% ± 20% | |
| type I pneumocyte | 8 studies | 32% ± 12% | |
| oligodendrocyte precursor cell | 8 studies | 24% ± 8% | |
| adipocyte | 8 studies | 28% ± 11% | |
| monocyte | 7 studies | 34% ± 13% | |
| classical monocyte | 7 studies | 25% ± 7% | |
| non-classical monocyte | 6 studies | 23% ± 7% | |
| basal cell | 6 studies | 28% ± 17% | |
| dendritic cell | 6 studies | 29% ± 9% | |
| ciliated cell | 6 studies | 26% ± 10% | |
| type II pneumocyte | 6 studies | 34% ± 12% | |
| fibroblast | 5 studies | 24% ± 4% | |
| interneuron | 4 studies | 29% ± 13% | |
| lymphocyte | 4 studies | 21% ± 6% | |
| GABAergic neuron | 4 studies | 34% ± 12% | |
| glutamatergic neuron | 4 studies | 44% ± 13% | |
| pericyte | 4 studies | 23% ± 5% | |
| oligodendrocyte | 4 studies | 25% ± 9% | |
| conventional dendritic cell | 3 studies | 25% ± 5% | |
| hematopoietic precursor cell | 3 studies | 31% ± 17% | |
| squamous epithelial cell | 3 studies | 42% ± 21% | |
| mononuclear phagocyte | 3 studies | 22% ± 3% | |
| neural progenitor cell | 3 studies | 26% ± 6% | |
| myofibroblast cell | 3 studies | 23% ± 5% | |
| alveolar macrophage | 3 studies | 40% ± 10% | |
| club cell | 3 studies | 31% ± 10% | |
| transit amplifying cell | 3 studies | 37% ± 26% | |
| neuron | 3 studies | 38% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 4327.86 | 1445 / 1445 | 100% | 52.13 | 183 / 183 |
| stomach | 100% | 1903.27 | 359 / 359 | 100% | 27.20 | 286 / 286 |
| lung | 100% | 3806.01 | 578 / 578 | 100% | 31.27 | 1153 / 1155 |
| ovary | 100% | 2441.38 | 180 / 180 | 100% | 26.63 | 429 / 430 |
| breast | 100% | 2722.04 | 459 / 459 | 100% | 33.60 | 1114 / 1118 |
| uterus | 100% | 2640.17 | 170 / 170 | 99% | 36.71 | 456 / 459 |
| intestine | 100% | 2688.97 | 966 / 966 | 99% | 26.23 | 523 / 527 |
| prostate | 100% | 2279.22 | 245 / 245 | 99% | 24.07 | 497 / 502 |
| bladder | 100% | 2490.43 | 21 / 21 | 99% | 25.46 | 497 / 504 |
| thymus | 100% | 1951.79 | 652 / 653 | 98% | 15.34 | 592 / 605 |
| pancreas | 99% | 1064.19 | 325 / 328 | 98% | 28.50 | 175 / 178 |
| skin | 100% | 3861.59 | 1809 / 1809 | 96% | 21.00 | 455 / 472 |
| kidney | 100% | 1535.82 | 89 / 89 | 93% | 15.76 | 838 / 901 |
| brain | 91% | 1046.99 | 2414 / 2642 | 99% | 15.54 | 698 / 705 |
| liver | 100% | 1262.25 | 226 / 226 | 86% | 9.98 | 348 / 406 |
| adrenal gland | 100% | 1588.64 | 258 / 258 | 84% | 10.99 | 193 / 230 |
| adipose | 100% | 2611.57 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 17.45 | 29 / 29 |
| spleen | 100% | 2276.31 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 11.37 | 1 / 1 |
| blood vessel | 100% | 1905.06 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 1964.16 | 802 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 2568.44 | 914 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 33.15 | 44 / 45 |
| heart | 95% | 1206.37 | 816 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 85% | 10.37 | 68 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006325 | Biological process | chromatin organization |
| GO_0030218 | Biological process | erythrocyte differentiation |
| GO_0045654 | Biological process | positive regulation of megakaryocyte differentiation |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0000118 | Cellular component | histone deacetylase complex |
| GO_1990391 | Cellular component | DNA repair complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0017053 | Cellular component | transcription repressor complex |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0003714 | Molecular function | transcription corepressor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0003682 | Molecular function | chromatin binding |
| Gene name | RCOR1 |
| Protein name | REST corepressor 1 REST corepressor 1 (Protein CoREST) Alternative protein RCOR1 |
| Synonyms | KIAA0071 RCOR |
| Description | FUNCTION: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. . |
| Accessions | H0YNY4 L0R8D2 Q9UKL0 ENST00000262241.7 ENST00000560472.1 |