PLA2G3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PLA2G3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLA2G3 at tissue level.

III. Associated gene sets

GO_0010744Biological processpositive regulation of macrophage derived foam cell differentiation
GO_0060271Biological processcilium assembly
GO_0007288Biological processsperm axoneme assembly
GO_0042116Biological processmacrophage activation
GO_0046488Biological processphosphatidylinositol metabolic process
GO_0010976Biological processpositive regulation of neuron projection development
GO_0010629Biological processnegative regulation of gene expression
GO_2001135Biological processregulation of endocytic recycling
GO_0006658Biological processphosphatidylserine metabolic process
GO_0019372Biological processlipoxygenase pathway
GO_0060376Biological processpositive regulation of mast cell differentiation
GO_0031394Biological processpositive regulation of prostaglandin biosynthetic process
GO_0034375Biological processhigh-density lipoprotein particle remodeling
GO_1900017Biological processpositive regulation of cytokine production involved in inflammatory response
GO_1903595Biological processpositive regulation of histamine secretion by mast cell
GO_0043303Biological processmast cell degranulation
GO_0002532Biological processproduction of molecular mediator involved in inflammatory response
GO_0034374Biological processlow-density lipoprotein particle remodeling
GO_0001675Biological processacrosome assembly
GO_0046470Biological processphosphatidylcholine metabolic process
GO_0046473Biological processphosphatidic acid metabolic process
GO_0032308Biological processpositive regulation of prostaglandin secretion
GO_0006644Biological processphospholipid metabolic process
GO_0046337Biological processphosphatidylethanolamine metabolic process
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0048469Biological processcell maturation
GO_0046471Biological processphosphatidylglycerol metabolic process
GO_1900222Biological processnegative regulation of amyloid-beta clearance
GO_0050482Biological processarachidonic acid secretion
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0055037Cellular componentrecycling endosome
GO_0005814Cellular componentcentriole
GO_0047498Molecular functioncalcium-dependent phospholipase A2 activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePLA2G3
Protein nameGroup 3 secretory phospholipase A2 (EC 3.1.1.4) (Group III secretory phospholipase A2) (GIII sPLA2) (sPLA2-III) (Phosphatidylcholine 2-acylhydrolase 3)
Synonyms
DescriptionFUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids without apparent head group selectivity . Contributes to phospholipid remodeling of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells . May act in an autocrine and paracrine manner . Secreted by immature mast cells, acts on nearby fibroblasts upstream to PTDGS to synthesize prostaglandin D2 (PGD2), which in turn promotes mast cell maturation and degranulation via PTGDR . Secreted by epididymal epithelium, acts on immature sperm cells within the duct, modulating the degree of unsaturation of the fatty acyl components of phosphatidylcholines required for acrosome assembly and sperm cell motility. Facilitates the replacement of fatty acyl chains in phosphatidylcholines in sperm membranes from omega-6 and omega-9 to omega-3 polyunsaturated fatty acids (PUFAs). Coupled to lipoxygenase pathway, may process omega-6 PUFAs to generate oxygenated lipid mediators in the male reproductive tract (By similarity). At pericentrosomal preciliary compartment, negatively regulates ciliogenesis likely by regulating endocytotic recycling of ciliary membrane protein . Coupled to cyclooxygenase pathway provides arachidonate to generate prostaglandin E2 (PGE2), a potent immunomodulatory lipid in inflammation and tumorigenesis . At colonic epithelial barrier, preferentially hydrolyzes phospholipids having arachidonate and docosahexaenoate at sn-2 position, contributing to the generation of oxygenated metabolites involved in colonic stem cell homeostasis . Releases C16:0 and C18:0 lysophosphatidylcholine subclasses from neuron plasma membranes and promotes neurite outgrowth and neuron survival . .

AccessionsQ9NZ20
ENST00000215885.4