ID2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000177Biological processregulation of neural precursor cell proliferation
GO_0045664Biological processregulation of neuron differentiation
GO_0045651Biological processpositive regulation of macrophage differentiation
GO_0045777Biological processpositive regulation of blood pressure
GO_0010629Biological processnegative regulation of gene expression
GO_0033598Biological processmammary gland epithelial cell proliferation
GO_0007507Biological processheart development
GO_0048663Biological processneuron fate commitment
GO_0045475Biological processlocomotor rhythm
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0061031Biological processendodermal digestive tract morphogenesis
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0010628Biological processpositive regulation of gene expression
GO_0048711Biological processpositive regulation of astrocyte differentiation
GO_0051148Biological processnegative regulation of muscle cell differentiation
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0019216Biological processregulation of lipid metabolic process
GO_0060749Biological processmammary gland alveolus development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0061030Biological processepithelial cell differentiation involved in mammary gland alveolus development
GO_0032922Biological processcircadian regulation of gene expression
GO_0021772Biological processolfactory bulb development
GO_0007623Biological processcircadian rhythm
GO_0042752Biological processregulation of circadian rhythm
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030154Biological processcell differentiation
GO_0048557Biological processembryonic digestive tract morphogenesis
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0043153Biological processentrainment of circadian clock by photoperiod
GO_0090398Biological processcellular senescence
GO_0043353Biological processenucleate erythrocyte differentiation
GO_0003166Biological processbundle of His development
GO_0045578Biological processnegative regulation of B cell differentiation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0000791Cellular componenteuchromatin
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0140416Molecular functiontranscription regulator inhibitor activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0140110Molecular functiontranscription regulator activity
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameID2
Protein nameDNA-binding protein inhibitor ID-2 (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2)
DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2)
SynonymshCG_1784377
BHLHB26
GIG8
DescriptionFUNCTION: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. .

FUNCTION: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. .

AccessionsENST00000396290.2
Q02363
Q53T66
ENST00000234091.8
ENST00000331129.3