ZNF410 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010629Biological processnegative regulation of gene expression
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNF410
Protein nameZinc finger protein 410, isoform CRA_c (cDNA FLJ53155, highly similar to Zinc finger protein 410)
Zinc finger protein 410
Zinc finger protein 410 (Another partner for ARF 1)
SynonymsAPA1
hCG_21725
DescriptionFUNCTION: Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells . Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells . May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence . May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose . However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 . .

AccessionsB4DPW2
ENST00000555730.6
G3V2C2
ENST00000334521.8
G3V369
ENST00000324593.10 [Q86VK4-3]
ENST00000442160.7 [Q86VK4-5]
ENST00000554316.1
G3V398
ENST00000540593.5 [Q86VK4-4]
ENST00000556396.5
G3V2V5
G3V2G5
J3KNQ6
ENST00000556659.5
ENST00000557214.2
H0YJI7
G3V4E6
ENST00000554582.5
ENST00000556160.5
ENST00000555044.6 [Q86VK4-1]
ENST00000557495.5
ENST00000398139.7 [Q86VK4-2]
ENST00000615736.4 [Q86VK4-5]
ENST00000556797.1
G3V4H7
G3V3W2
ENST00000556179.5
Q86VK4
G3V4W2
ENST00000554797.3