RB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000679Biological processpositive regulation of transcription regulatory region DNA binding
GO_0006366Biological processtranscription by RNA polymerase II
GO_0045786Biological processnegative regulation of cell cycle
GO_0045651Biological processpositive regulation of macrophage differentiation
GO_0002062Biological processchondrocyte differentiation
GO_0051301Biological processcell division
GO_0051402Biological processneuron apoptotic process
GO_0050728Biological processnegative regulation of inflammatory response
GO_0034088Biological processmaintenance of mitotic sister chromatid cohesion
GO_0097284Biological processhepatocyte apoptotic process
GO_0007346Biological processregulation of mitotic cell cycle
GO_1902948Biological processnegative regulation of tau-protein kinase activity
GO_2001234Biological processnegative regulation of apoptotic signaling pathway
GO_0051726Biological processregulation of cell cycle
GO_0050673Biological processepithelial cell proliferation
GO_0071459Biological processprotein localization to chromosome, centromeric region
GO_0007224Biological processsmoothened signaling pathway
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0034349Biological processglial cell apoptotic process
GO_1904761Biological processnegative regulation of myofibroblast differentiation
GO_0010629Biological processnegative regulation of gene expression
GO_0031175Biological processneuron projection development
GO_0045879Biological processnegative regulation of smoothened signaling pathway
GO_0031507Biological processheterochromatin formation
GO_0048667Biological processcell morphogenesis involved in neuron differentiation
GO_1903055Biological processpositive regulation of extracellular matrix organization
GO_0031134Biological processsister chromatid biorientation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0043550Biological processregulation of lipid kinase activity
GO_0048565Biological processdigestive tract development
GO_0001894Biological processtissue homeostasis
GO_0030308Biological processnegative regulation of cell growth
GO_0007265Biological processRas protein signal transduction
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0032869Biological processcellular response to insulin stimulus
GO_0003180Biological processaortic valve morphogenesis
GO_0051146Biological processstriated muscle cell differentiation
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_1903944Biological processnegative regulation of hepatocyte apoptotic process
GO_0042551Biological processneuron maturation
GO_0090230Biological processregulation of centromere complex assembly
GO_0060253Biological processnegative regulation of glial cell proliferation
GO_0045445Biological processmyoblast differentiation
GO_0043353Biological processenucleate erythrocyte differentiation
GO_0035914Biological processskeletal muscle cell differentiation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0071901Biological processnegative regulation of protein serine/threonine kinase activity
GO_0007283Biological processspermatogenesis
GO_0045842Biological processpositive regulation of mitotic metaphase/anaphase transition
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0051276Biological processchromosome organization
GO_0030154Biological processcell differentiation
GO_1904028Biological processpositive regulation of collagen fibril organization
GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_0014009Biological processglial cell proliferation
GO_0016605Cellular componentPML body
GO_0005634Cellular componentnucleus
GO_0016514Cellular componentSWI/SNF complex
GO_0005654Cellular componentnucleoplasm
GO_0061793Cellular componentchromatin lock complex
GO_0000785Cellular componentchromatin
GO_0008024Cellular componentcyclin/CDK positive transcription elongation factor complex
GO_0035189Cellular componentRb-E2F complex
GO_0005829Cellular componentcytosol
GO_0005819Cellular componentspindle
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0019900Molecular functionkinase binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0005515Molecular functionprotein binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0061676Molecular functionimportin-alpha family protein binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0051219Molecular functionphosphoprotein binding
GO_0097718Molecular functiondisordered domain specific binding

IV. Literature review

[source]
Gene nameRB1
Protein nameRetinoblastoma susceptibility protein (Retinoblastoma suspectibility protein)
Mutated retinoblastoma protein (RB transcriptional corepressor 1)
Retinoblastoma susceptibility protein
RB1 protein
RB1 protein (Retinoblastoma)
Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)
Mutant retinoblastoma-associated protein
Retinoblastoma 1
Retinoblastoma suspectibility protein
RB transcriptional corepressor 1 (RB1 protein)
RB transcriptional corepressor 1
Synonyms
DescriptionFUNCTION: Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle . The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes . Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription . Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase . RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C . Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). .; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. .

AccessionsV9GZQ2
Q6LE82
A0A2R8Y743
V9H012
ENST00000643064.1
A0A0X9QC09
Q6LE79
Q7KZ59
Q7Z5Q6
ENST00000467505.5
Q6LE65
A0A385FS33
A0A385FS65
A0A385FS44
P78495
A0A385FS48
ENST00000267163.6
Q7KZ61
ENST00000646097.1
Q86WG4
A0A385FS40
A0A385FS38
V9GZJ8
V9H058
Q2PMD0
Q6LE80
Q6DUF0
A0A3B3IS71
ENST00000650461.1
V9H0A9
V9H020
A0A385FS41
V9H0D2
Q6LE77
A0A385FS12
Q6LE76
Q6LE81
Q92727
Q92728
Q7KZ60
A0A2R8YFL6
A0A385FS25
P06400