Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 36 studies | 39% ± 16% | |
endothelial cell | 34 studies | 36% ± 14% | |
B cell | 25 studies | 28% ± 10% | |
naive B cell | 18 studies | 27% ± 6% | |
microglial cell | 18 studies | 47% ± 17% | |
conventional dendritic cell | 16 studies | 26% ± 15% | |
classical monocyte | 16 studies | 23% ± 7% | |
non-classical monocyte | 16 studies | 24% ± 7% | |
astrocyte | 15 studies | 35% ± 17% | |
monocyte | 14 studies | 32% ± 15% | |
dendritic cell | 14 studies | 32% ± 12% | |
memory B cell | 13 studies | 22% ± 4% | |
pericyte | 13 studies | 29% ± 12% | |
oligodendrocyte precursor cell | 12 studies | 30% ± 16% | |
fibroblast | 12 studies | 30% ± 11% | |
capillary endothelial cell | 11 studies | 23% ± 8% | |
myeloid cell | 11 studies | 41% ± 14% | |
glutamatergic neuron | 10 studies | 41% ± 25% | |
oligodendrocyte | 10 studies | 31% ± 14% | |
GABAergic neuron | 9 studies | 40% ± 22% | |
natural killer cell | 8 studies | 19% ± 4% | |
adipocyte | 8 studies | 35% ± 11% | |
smooth muscle cell | 8 studies | 30% ± 10% | |
mononuclear phagocyte | 7 studies | 37% ± 17% | |
endothelial cell of artery | 7 studies | 21% ± 4% | |
neuron | 6 studies | 34% ± 20% | |
leukocyte | 6 studies | 30% ± 12% | |
plasmacytoid dendritic cell | 6 studies | 25% ± 7% | |
precursor B cell | 6 studies | 36% ± 10% | |
epithelial cell | 6 studies | 37% ± 17% | |
CD8-positive, alpha-beta T cell | 6 studies | 17% ± 2% | |
vein endothelial cell | 6 studies | 30% ± 18% | |
T cell | 6 studies | 20% ± 4% | |
endothelial cell of lymphatic vessel | 6 studies | 31% ± 8% | |
basal cell | 6 studies | 29% ± 17% | |
plasma cell | 5 studies | 34% ± 9% | |
pro-B cell | 5 studies | 32% ± 5% | |
mast cell | 5 studies | 27% ± 10% | |
ciliated cell | 5 studies | 24% ± 6% | |
type I pneumocyte | 5 studies | 23% ± 5% | |
interneuron | 5 studies | 45% ± 25% | |
glial cell | 4 studies | 25% ± 1% | |
immature B cell | 4 studies | 35% ± 11% | |
cardiac muscle cell | 4 studies | 28% ± 1% | |
lymphocyte | 4 studies | 27% ± 7% | |
Mueller cell | 4 studies | 23% ± 7% | |
endothelial cell of vascular tree | 4 studies | 39% ± 18% | |
club cell | 4 studies | 22% ± 6% | |
type II pneumocyte | 4 studies | 18% ± 3% | |
plasmablast | 3 studies | 42% ± 17% | |
glomerular endothelial cell | 3 studies | 20% ± 1% | |
GABAergic interneuron | 3 studies | 21% ± 2% | |
retinal ganglion cell | 3 studies | 22% ± 9% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 19% ± 1% | |
retinal pigment epithelial cell | 3 studies | 32% ± 19% | |
CD4-positive, alpha-beta T cell | 3 studies | 18% ± 1% | |
tissue-resident macrophage | 3 studies | 41% ± 10% | |
retinal rod cell | 3 studies | 20% ± 2% | |
intermediate monocyte | 3 studies | 29% ± 6% | |
neural progenitor cell | 3 studies | 25% ± 5% | |
connective tissue cell | 3 studies | 28% ± 3% | |
ependymal cell | 3 studies | 36% ± 18% | |
alveolar macrophage | 3 studies | 43% ± 11% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 17% ± 2% | |
transit amplifying cell | 3 studies | 42% ± 33% | |
mesothelial cell | 3 studies | 28% ± 5% | |
granule cell | 3 studies | 26% ± 6% | |
abnormal cell | 3 studies | 32% ± 12% | |
mural cell | 3 studies | 36% ± 8% | |
mucus secreting cell | 3 studies | 24% ± 4% | |
regulatory T cell | 3 studies | 17% ± 0% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2626.83 | 1445 / 1445 | 100% | 62.36 | 183 / 183 |
brain | 100% | 1708.74 | 2635 / 2642 | 100% | 43.41 | 702 / 705 |
thymus | 100% | 2606.00 | 653 / 653 | 98% | 32.20 | 594 / 605 |
lung | 100% | 2996.31 | 578 / 578 | 98% | 31.19 | 1132 / 1155 |
stomach | 100% | 1503.33 | 359 / 359 | 97% | 41.43 | 277 / 286 |
intestine | 100% | 2133.36 | 966 / 966 | 97% | 36.24 | 509 / 527 |
kidney | 100% | 1764.44 | 89 / 89 | 96% | 43.85 | 868 / 901 |
breast | 100% | 2767.66 | 459 / 459 | 96% | 34.06 | 1068 / 1118 |
prostate | 100% | 2035.65 | 245 / 245 | 95% | 24.17 | 478 / 502 |
adrenal gland | 100% | 2875.62 | 258 / 258 | 93% | 20.12 | 214 / 230 |
uterus | 100% | 2288.75 | 170 / 170 | 93% | 35.66 | 427 / 459 |
pancreas | 94% | 904.44 | 309 / 328 | 98% | 26.68 | 174 / 178 |
skin | 99% | 1928.58 | 1799 / 1809 | 92% | 38.43 | 435 / 472 |
ovary | 100% | 1809.01 | 180 / 180 | 91% | 23.49 | 393 / 430 |
bladder | 100% | 2141.86 | 21 / 21 | 90% | 25.52 | 456 / 504 |
liver | 96% | 804.77 | 216 / 226 | 56% | 8.42 | 228 / 406 |
adipose | 100% | 3191.85 | 1204 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 2451.69 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2858.49 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 40.05 | 45 / 45 |
blood vessel | 100% | 2450.71 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 1626.61 | 855 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 90% | 2870.24 | 836 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 90% | 42.14 | 26 / 29 |
eye | 0% | 0 | 0 / 0 | 68% | 12.58 | 54 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_2000679 | Biological process | positive regulation of transcription regulatory region DNA binding |
GO_0006366 | Biological process | transcription by RNA polymerase II |
GO_0045786 | Biological process | negative regulation of cell cycle |
GO_0045651 | Biological process | positive regulation of macrophage differentiation |
GO_0002062 | Biological process | chondrocyte differentiation |
GO_0051301 | Biological process | cell division |
GO_0051402 | Biological process | neuron apoptotic process |
GO_0050728 | Biological process | negative regulation of inflammatory response |
GO_0034088 | Biological process | maintenance of mitotic sister chromatid cohesion |
GO_0097284 | Biological process | hepatocyte apoptotic process |
GO_0007346 | Biological process | regulation of mitotic cell cycle |
GO_1902948 | Biological process | negative regulation of tau-protein kinase activity |
GO_2001234 | Biological process | negative regulation of apoptotic signaling pathway |
GO_0051726 | Biological process | regulation of cell cycle |
GO_0050673 | Biological process | epithelial cell proliferation |
GO_0071459 | Biological process | protein localization to chromosome, centromeric region |
GO_0007224 | Biological process | smoothened signaling pathway |
GO_0071466 | Biological process | cellular response to xenobiotic stimulus |
GO_0034349 | Biological process | glial cell apoptotic process |
GO_1904761 | Biological process | negative regulation of myofibroblast differentiation |
GO_0010629 | Biological process | negative regulation of gene expression |
GO_0031175 | Biological process | neuron projection development |
GO_0045879 | Biological process | negative regulation of smoothened signaling pathway |
GO_0031507 | Biological process | heterochromatin formation |
GO_0048667 | Biological process | cell morphogenesis involved in neuron differentiation |
GO_1903055 | Biological process | positive regulation of extracellular matrix organization |
GO_0031134 | Biological process | sister chromatid biorientation |
GO_0006355 | Biological process | regulation of DNA-templated transcription |
GO_0043550 | Biological process | regulation of lipid kinase activity |
GO_0048565 | Biological process | digestive tract development |
GO_0001894 | Biological process | tissue homeostasis |
GO_0030308 | Biological process | negative regulation of cell growth |
GO_0007265 | Biological process | Ras protein signal transduction |
GO_0006469 | Biological process | negative regulation of protein kinase activity |
GO_0032869 | Biological process | cellular response to insulin stimulus |
GO_0003180 | Biological process | aortic valve morphogenesis |
GO_0051146 | Biological process | striated muscle cell differentiation |
GO_0043433 | Biological process | negative regulation of DNA-binding transcription factor activity |
GO_1903944 | Biological process | negative regulation of hepatocyte apoptotic process |
GO_0042551 | Biological process | neuron maturation |
GO_0090230 | Biological process | regulation of centromere complex assembly |
GO_0060253 | Biological process | negative regulation of glial cell proliferation |
GO_0045445 | Biological process | myoblast differentiation |
GO_0043353 | Biological process | enucleate erythrocyte differentiation |
GO_0035914 | Biological process | skeletal muscle cell differentiation |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0000082 | Biological process | G1/S transition of mitotic cell cycle |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0120163 | Biological process | negative regulation of cold-induced thermogenesis |
GO_0071901 | Biological process | negative regulation of protein serine/threonine kinase activity |
GO_0007283 | Biological process | spermatogenesis |
GO_0045842 | Biological process | positive regulation of mitotic metaphase/anaphase transition |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0006338 | Biological process | chromatin remodeling |
GO_0050680 | Biological process | negative regulation of epithelial cell proliferation |
GO_0051276 | Biological process | chromosome organization |
GO_0030154 | Biological process | cell differentiation |
GO_1904028 | Biological process | positive regulation of collagen fibril organization |
GO_2000134 | Biological process | negative regulation of G1/S transition of mitotic cell cycle |
GO_0014009 | Biological process | glial cell proliferation |
GO_0016605 | Cellular component | PML body |
GO_0005634 | Cellular component | nucleus |
GO_0016514 | Cellular component | SWI/SNF complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0061793 | Cellular component | chromatin lock complex |
GO_0000785 | Cellular component | chromatin |
GO_0008024 | Cellular component | cyclin/CDK positive transcription elongation factor complex |
GO_0035189 | Cellular component | Rb-E2F complex |
GO_0005829 | Cellular component | cytosol |
GO_0005819 | Cellular component | spindle |
GO_0140297 | Molecular function | DNA-binding transcription factor binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0060090 | Molecular function | molecular adaptor activity |
GO_0019900 | Molecular function | kinase binding |
GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
GO_0005515 | Molecular function | protein binding |
GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
GO_0061676 | Molecular function | importin-alpha family protein binding |
GO_0003714 | Molecular function | transcription corepressor activity |
GO_0051219 | Molecular function | phosphoprotein binding |
GO_0097718 | Molecular function | disordered domain specific binding |
Gene name | RB1 |
Protein name | Retinoblastoma susceptibility protein (Retinoblastoma suspectibility protein) Mutated retinoblastoma protein (RB transcriptional corepressor 1) Retinoblastoma susceptibility protein RB1 protein RB1 protein (Retinoblastoma) Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) Mutant retinoblastoma-associated protein Retinoblastoma 1 Retinoblastoma suspectibility protein RB transcriptional corepressor 1 (RB1 protein) RB transcriptional corepressor 1 |
Synonyms | |
Description | FUNCTION: Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle . The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes . Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription . Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase . RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C . Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). .; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. . |
Accessions | V9GZQ2 Q6LE82 A0A2R8Y743 V9H012 ENST00000643064.1 A0A0X9QC09 Q6LE79 Q7KZ59 Q7Z5Q6 ENST00000467505.5 Q6LE65 A0A385FS33 A0A385FS65 A0A385FS44 P78495 A0A385FS48 ENST00000267163.6 Q7KZ61 ENST00000646097.1 Q86WG4 A0A385FS40 A0A385FS38 V9GZJ8 V9H058 Q2PMD0 Q6LE80 Q6DUF0 A0A3B3IS71 ENST00000650461.1 V9H0A9 V9H020 A0A385FS41 V9H0D2 Q6LE77 A0A385FS12 Q6LE76 Q6LE81 Q92727 Q92728 Q7KZ60 A0A2R8YFL6 A0A385FS25 P06400 |