PDCD10 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	25 studies	21% ± 4%	Explore
endothelial cell	22 studies	24% ± 9%	Explore
CD8-positive, alpha-beta T cell	17 studies	21% ± 4%	Explore
regulatory T cell	17 studies	22% ± 5%	Explore
B cell	15 studies	21% ± 6%	Explore
CD4-positive, alpha-beta T cell	15 studies	20% ± 5%	Explore
pericyte	13 studies	20% ± 4%	Explore
gamma-delta T cell	12 studies	24% ± 10%	Explore
macrophage	11 studies	22% ± 7%	Explore
naive B cell	11 studies	20% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	20% ± 5%	Explore
T cell	10 studies	20% ± 4%	Explore
classical monocyte	10 studies	21% ± 8%	Explore
non-classical monocyte	10 studies	26% ± 11%	Explore
mature NK T cell	10 studies	20% ± 2%	Explore
endothelial cell of lymphatic vessel	9 studies	21% ± 5%	Explore
basal cell	9 studies	33% ± 15%	Explore
mucosal invariant T cell	9 studies	19% ± 3%	Explore
memory B cell	9 studies	20% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	22% ± 7%	Explore
monocyte	8 studies	20% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	20% ± 4%	Explore
platelet	8 studies	28% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	21% ± 4%	Explore
epithelial cell	8 studies	38% ± 19%	Explore
ciliated cell	8 studies	32% ± 14%	Explore
fibroblast	8 studies	21% ± 6%	Explore
smooth muscle cell	7 studies	20% ± 5%	Explore
conventional dendritic cell	7 studies	27% ± 14%	Explore
capillary endothelial cell	7 studies	18% ± 1%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	21% ± 6%	Explore
plasmacytoid dendritic cell	7 studies	22% ± 7%	Explore
type I pneumocyte	6 studies	22% ± 7%	Explore
secretory cell	6 studies	27% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	21% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	24% ± 4%	Explore
vein endothelial cell	6 studies	20% ± 6%	Explore
endothelial cell of vascular tree	6 studies	20% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	23% ± 2%	Explore
endothelial cell of artery	5 studies	17% ± 3%	Explore
lymphocyte	5 studies	22% ± 8%	Explore
T follicular helper cell	5 studies	17% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	23% ± 4%	Explore
innate lymphoid cell	5 studies	20% ± 4%	Explore
goblet cell	5 studies	30% ± 10%	Explore
exhausted T cell	4 studies	25% ± 8%	Explore
club cell	4 studies	27% ± 5%	Explore
astrocyte	4 studies	30% ± 5%	Explore
alveolar macrophage	4 studies	20% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	24% ± 5%	Explore
abnormal cell	4 studies	20% ± 2%	Explore
erythrocyte	4 studies	46% ± 20%	Explore
oligodendrocyte	4 studies	28% ± 2%	Explore
respiratory goblet cell	3 studies	25% ± 12%	Explore
squamous epithelial cell	3 studies	36% ± 26%	Explore
pancreatic A cell	3 studies	24% ± 0%	Explore
leukocyte	3 studies	25% ± 4%	Explore
hematopoietic precursor cell	3 studies	28% ± 12%	Explore
myofibroblast cell	3 studies	16% ± 1%	Explore
myeloid cell	3 studies	32% ± 12%	Explore
mononuclear phagocyte	3 studies	24% ± 7%	Explore
erythroblast	3 studies	37% ± 26%	Explore
GABAergic neuron	3 studies	42% ± 7%	Explore
glutamatergic neuron	3 studies	60% ± 4%	Explore
pancreatic ductal cell	3 studies	33% ± 12%	Explore
megakaryocyte	3 studies	44% ± 10%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	34% ± 21%	Explore
T-helper 17 cell	3 studies	21% ± 1%	Explore
T-helper 1 cell	3 studies	20% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	21% ± 5%	Explore
double negative thymocyte	3 studies	28% ± 8%	Explore
microglial cell	3 studies	21% ± 5%	Explore
connective tissue cell	3 studies	18% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	22% ± 6%	Explore
lung	9 studies	28% ± 13%	Explore
liver	5 studies	29% ± 21%	Explore
brain	4 studies	43% ± 7%	Explore
pancreas	3 studies	26% ± 4%	Explore
intestine	3 studies	22% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1897.54	1445 / 1445	100%	58.39	183 / 183
ovary	100%	1191.92	180 / 180	100%	55.40	430 / 430
uterus	100%	1365.66	170 / 170	100%	59.40	459 / 459
breast	100%	1827.91	459 / 459	100%	49.94	1117 / 1118
lung	100%	1592.60	577 / 578	100%	62.99	1154 / 1155
brain	100%	1168.98	2638 / 2642	100%	29.93	703 / 705
prostate	100%	1306.00	245 / 245	99%	32.36	498 / 502
stomach	100%	1402.28	359 / 359	99%	43.57	283 / 286
bladder	100%	1454.62	21 / 21	99%	44.68	498 / 504
intestine	100%	1808.48	966 / 966	98%	44.75	519 / 527
thymus	100%	1465.61	653 / 653	98%	31.20	595 / 605
pancreas	99%	771.22	325 / 328	99%	35.05	176 / 178
kidney	100%	1536.29	89 / 89	96%	26.34	865 / 901
liver	100%	779.53	226 / 226	91%	17.63	368 / 406
skin	100%	1638.00	1808 / 1809	89%	26.63	421 / 472
adrenal gland	100%	1461.05	258 / 258	88%	16.92	202 / 230
blood vessel	100%	1897.41	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	39.08	29 / 29
spleen	100%	1676.68	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	68.94	45 / 45
ureter	0%	0	0 / 0	100%	8.69	1 / 1
adipose	100%	1789.62	1203 / 1204	0%	0	0 / 0
heart	98%	975.53	847 / 861	0%	0	0 / 0
muscle	98%	650.63	785 / 803	0%	0	0 / 0
peripheral blood	87%	1630.01	804 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	43%	5.70	34 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0090051	Biological process	negative regulation of cell migration involved in sprouting angiogenesis
GO_0001525	Biological process	angiogenesis
GO_1903588	Biological process	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO_0032874	Biological process	positive regulation of stress-activated MAPK cascade
GO_0010629	Biological process	negative regulation of gene expression
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_0010628	Biological process	positive regulation of gene expression
GO_0051683	Biological process	establishment of Golgi localization
GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_0090168	Biological process	Golgi reassembly
GO_0045765	Biological process	regulation of angiogenesis
GO_1903358	Biological process	regulation of Golgi organization
GO_0043406	Biological process	positive regulation of MAP kinase activity
GO_0035556	Biological process	intracellular signal transduction
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0030335	Biological process	positive regulation of cell migration
GO_0050821	Biological process	protein stabilization
GO_0035023	Biological process	regulation of Rho protein signal transduction
GO_0003158	Biological process	endothelium development
GO_0044319	Biological process	wound healing, spreading of cells
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0036481	Biological process	intrinsic apoptotic signaling pathway in response to hydrogen peroxide
GO_0043149	Biological process	stress fiber assembly
GO_0045747	Biological process	positive regulation of Notch signaling pathway
GO_0071902	Biological process	positive regulation of protein serine/threonine kinase activity
GO_0090316	Biological process	positive regulation of intracellular protein transport
GO_0005886	Cellular component	plasma membrane
GO_0090443	Cellular component	FAR/SIN/STRIPAK complex
GO_0070062	Cellular component	extracellular exosome
GO_0005794	Cellular component	Golgi apparatus
GO_0000139	Cellular component	Golgi membrane
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0042803	Molecular function	protein homodimerization activity
GO_0019901	Molecular function	protein kinase binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PDCD10
Protein name	Programmed cell death 10 Programmed cell death protein 10 (Cerebral cavernous malformations 3 protein) (TF-1 cell apoptosis-related protein 15)
Synonyms	hCG_27561 CCM3 TFAR15
Description	FUNCTION: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity . Important for cell migration, and for normal structure and assembly of the Golgi complex . Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). .
Accessions	ENST00000492139.5 C9J6F3 C9JSA3 ENST00000461494.5 ENST00000479121.5 ENST00000492396.5 ENST00000487947.6 C9J363 ENST00000475915.6 ENST00000471885.5 C9J5C3 ENST00000497056.6 Q9BUL8 C9JND6 ENST00000462725.6 ENST00000464360.5 H7C5M9 ENST00000473645.6 ENST00000494502.6 F8WDF3 ENST00000392750.7 ENST00000470131.5 C9J932

PDCD10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review