PINK1 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	15 studies	28% ± 12%	Explore
glutamatergic neuron	5 studies	35% ± 19%	Explore
capillary endothelial cell	4 studies	23% ± 4%	Explore
endothelial cell of artery	4 studies	17% ± 2%	Explore
retinal ganglion cell	4 studies	60% ± 23%	Explore
GABAergic neuron	4 studies	34% ± 9%	Explore
ionocyte	3 studies	30% ± 5%	Explore
glomerular endothelial cell	3 studies	36% ± 5%	Explore
neuron	3 studies	30% ± 5%	Explore
squamous epithelial cell	3 studies	23% ± 5%	Explore
retinal cone cell	3 studies	42% ± 8%	Explore
fibroblast	3 studies	19% ± 3%	Explore
epithelial cell	3 studies	25% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	5 studies	26% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	4193.16	2642 / 2642	99%	37.62	701 / 705
prostate	99%	1407.16	243 / 245	98%	15.89	493 / 502
intestine	100%	1857.99	962 / 966	97%	10.10	512 / 527
stomach	99%	1460.89	355 / 359	97%	10.19	278 / 286
esophagus	100%	2000.91	1439 / 1445	96%	9.03	176 / 183
breast	100%	1738.23	458 / 459	96%	10.43	1070 / 1118
kidney	100%	1813.22	89 / 89	95%	17.18	860 / 901
skin	100%	1788.49	1806 / 1809	96%	10.83	451 / 472
thymus	99%	1688.96	649 / 653	96%	17.25	580 / 605
bladder	100%	1696.38	21 / 21	94%	9.88	474 / 504
uterus	100%	1539.92	170 / 170	92%	9.03	423 / 459
lung	96%	1196.62	556 / 578	95%	9.31	1102 / 1155
adrenal gland	100%	4745.74	258 / 258	91%	19.10	209 / 230
ovary	96%	1157.46	172 / 180	94%	10.41	404 / 430
liver	92%	1290.61	207 / 226	91%	10.90	368 / 406
pancreas	74%	630.41	244 / 328	98%	13.01	175 / 178
muscle	100%	8068.99	803 / 803	0%	0	0 / 0
adipose	100%	1838.11	1202 / 1204	0%	0	0 / 0
blood vessel	100%	1949.33	1330 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	96%	13.28	77 / 80
tonsil	0%	0	0 / 0	96%	8.17	43 / 45
spleen	95%	986.00	230 / 241	0%	0	0 / 0
heart	94%	3089.42	808 / 861	0%	0	0 / 0
peripheral blood	80%	2006.07	747 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	62%	3.22	18 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0033603	Biological process	positive regulation of dopamine secretion
GO_0010821	Biological process	regulation of mitochondrion organization
GO_0016242	Biological process	negative regulation of macroautophagy
GO_1903377	Biological process	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO_0051443	Biological process	positive regulation of ubiquitin-protein transferase activity
GO_1903751	Biological process	negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
GO_0099074	Biological process	mitochondrion to lysosome vesicle-mediated transport
GO_0050821	Biological process	protein stabilization
GO_0022904	Biological process	respiratory electron transport chain
GO_0072655	Biological process	establishment of protein localization to mitochondrion
GO_0046329	Biological process	negative regulation of JNK cascade
GO_1903384	Biological process	negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0000423	Biological process	mitophagy
GO_2001243	Biological process	negative regulation of intrinsic apoptotic signaling pathway
GO_0006468	Biological process	protein phosphorylation
GO_1903298	Biological process	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
GO_0006979	Biological process	response to oxidative stress
GO_0061136	Biological process	regulation of proteasomal protein catabolic process
GO_2001171	Biological process	positive regulation of ATP biosynthetic process
GO_0090200	Biological process	positive regulation of release of cytochrome c from mitochondria
GO_0098779	Biological process	positive regulation of mitophagy in response to mitochondrial depolarization
GO_0002931	Biological process	response to ischemia
GO_0032226	Biological process	positive regulation of synaptic transmission, dopaminergic
GO_0010629	Biological process	negative regulation of gene expression
GO_0031396	Biological process	regulation of protein ubiquitination
GO_1901525	Biological process	negative regulation of mitophagy
GO_0042981	Biological process	regulation of apoptotic process
GO_0016239	Biological process	positive regulation of macroautophagy
GO_0010952	Biological process	positive regulation of peptidase activity
GO_1902902	Biological process	negative regulation of autophagosome assembly
GO_0045727	Biological process	positive regulation of translation
GO_0000422	Biological process	autophagy of mitochondrion
GO_1904881	Biological process	cellular response to hydrogen sulfide
GO_0031398	Biological process	positive regulation of protein ubiquitination
GO_0090258	Biological process	negative regulation of mitochondrial fission
GO_1902958	Biological process	positive regulation of mitochondrial electron transport, NADH to ubiquinone
GO_0036289	Biological process	peptidyl-serine autophosphorylation
GO_0010310	Biological process	regulation of hydrogen peroxide metabolic process
GO_1904544	Biological process	positive regulation of free ubiquitin chain polymerization
GO_0016567	Biological process	protein ubiquitination
GO_2000377	Biological process	regulation of reactive oxygen species metabolic process
GO_0030097	Biological process	hemopoiesis
GO_0032148	Biological process	activation of protein kinase B activity
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0038203	Biological process	TORC2 signaling
GO_0034599	Biological process	cellular response to oxidative stress
GO_0007005	Biological process	mitochondrion organization
GO_1900407	Biological process	regulation of cellular response to oxidative stress
GO_0043254	Biological process	regulation of protein-containing complex assembly
GO_1903955	Biological process	positive regulation of protein targeting to mitochondrion
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0018105	Biological process	peptidyl-serine phosphorylation
GO_0090141	Biological process	positive regulation of mitochondrial fission
GO_1903214	Biological process	regulation of protein targeting to mitochondrion
GO_0014046	Biological process	dopamine secretion
GO_1902803	Biological process	regulation of synaptic vesicle transport
GO_2000378	Biological process	negative regulation of reactive oxygen species metabolic process
GO_1903146	Biological process	regulation of autophagy of mitochondrion
GO_0051881	Biological process	regulation of mitochondrial membrane potential
GO_0035556	Biological process	intracellular signal transduction
GO_0072656	Biological process	maintenance of protein location in mitochondrion
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_1903852	Biological process	positive regulation of cristae formation
GO_0002082	Biological process	regulation of oxidative phosphorylation
GO_0097237	Biological process	cellular response to toxic substance
GO_0035307	Biological process	positive regulation of protein dephosphorylation
GO_0071456	Biological process	cellular response to hypoxia
GO_0005856	Cellular component	cytoskeleton
GO_0097449	Cellular component	astrocyte projection
GO_0005634	Cellular component	nucleus
GO_0097413	Cellular component	Lewy body
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0005758	Cellular component	mitochondrial intermembrane space
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005737	Cellular component	cytoplasm
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0030424	Cellular component	axon
GO_0000785	Cellular component	chromatin
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005829	Cellular component	cytosol
GO_0030426	Cellular component	growth cone
GO_0044297	Cellular component	cell body
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0004672	Molecular function	protein kinase activity
GO_0005524	Molecular function	ATP binding
GO_0106310	Molecular function	protein serine kinase activity
GO_0055131	Molecular function	C3HC4-type RING finger domain binding
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0000287	Molecular function	magnesium ion binding
GO_0002020	Molecular function	protease binding
GO_0005515	Molecular function	protein binding
GO_1904841	Molecular function	TORC2 complex binding
GO_0044877	Molecular function	protein-containing complex binding
GO_0016504	Molecular function	peptidase activator activity
GO_0016301	Molecular function	kinase activity
GO_0043422	Molecular function	protein kinase B binding
GO_0010857	Molecular function	calcium-dependent protein kinase activity

IV. Literature review

[source]

Gene name	PINK1
Protein name	Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)
Synonyms
Description	FUNCTION: Serine/threonine-protein kinase which protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins such as PRKN and DNM1L, to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components . Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy . Mediates the translocation and activation of PRKN at the outer membrane (OMM) of dysfunctional/depolarized mitochondria . At the OMM of damaged mitochondria, phosphorylates pre-existing polyubiquitin chains at 'Ser-65', the PINK1-phosphorylated polyubiquitin then recruits PRKN from the cytosol to the OMM where PRKN is fully activated by phosphorylation at 'Ser-65' by PINK1 . In damaged mitochondria, mediates the decision between mitophagy or preventing apoptosis by promoting PRKN-dependent poly- or monoubiquitination of VDAC1; polyubiquitination of VDAC1 by PRKN promotes mitophagy, while monoubiquitination of VDAC1 by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis . When cellular stress results in irreversible mitochondrial damage, functions with PRKN to promote clearance of damaged mitochondria via selective autophagy (mitophagy) . The PINK1-PRKN pathway also promotes fission of damaged mitochondria by phosphorylating and thus promoting the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 . This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes . Also promotes mitochondrial fission independently of PRKN and ATG7-mediated mitophagy, via the phosphorylation and activation of DNM1L . Regulates motility of damaged mitochondria by promoting the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma . Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity). Phosphorylates LETM1, positively regulating its mitochondrial calcium transport activity . .
Accessions	ENST00000321556.5 [Q9BXM7-1] Q9BXM7

PINK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review