PTPN22 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031663Biological processlipopolysaccharide-mediated signaling pathway
GO_1901222Biological processregulation of non-canonical NF-kappaB signal transduction
GO_0006470Biological processprotein dephosphorylation
GO_0070433Biological processnegative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO_0010629Biological processnegative regulation of gene expression
GO_1902523Biological processpositive regulation of protein K63-linked ubiquitination
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0050860Biological processnegative regulation of T cell receptor signaling pathway
GO_0010628Biological processpositive regulation of gene expression
GO_0050868Biological processnegative regulation of T cell activation
GO_0032481Biological processpositive regulation of type I interferon production
GO_0050852Biological processT cell receptor signaling pathway
GO_0043508Biological processnegative regulation of JUN kinase activity
GO_0045088Biological processregulation of innate immune response
GO_1900227Biological processpositive regulation of NLRP3 inflammasome complex assembly
GO_0030217Biological processT cell differentiation
GO_0034145Biological processpositive regulation of toll-like receptor 4 signaling pathway
GO_0050855Biological processregulation of B cell receptor signaling pathway
GO_0032717Biological processnegative regulation of interleukin-8 production
GO_0010507Biological processnegative regulation of autophagy
GO_0032729Biological processpositive regulation of type II interferon production
GO_0006914Biological processautophagy
GO_0032817Biological processregulation of natural killer cell proliferation
GO_0035644Biological processphosphoanandamide dephosphorylation
GO_0071225Biological processcellular response to muramyl dipeptide
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0006629Biological processlipid metabolic process
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0034141Biological processpositive regulation of toll-like receptor 3 signaling pathway
GO_0032496Biological processresponse to lipopolysaccharide
GO_1903753Biological processnegative regulation of p38MAPK cascade
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0005634Cellular componentnucleus
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0004726Molecular functionnon-membrane spanning protein tyrosine phosphatase activity
GO_0019900Molecular functionkinase binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0016791Molecular functionphosphatase activity
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene namePTPN22
Protein nameTyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP)
protein-tyrosine-phosphatase (EC 3.1.3.48)
Protein tyrosine phosphatase non-receptor type 22
SynonymsPTPN8
DescriptionFUNCTION: Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules . Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue . Dephosphorylates ZAP70 at its activating 'Tyr-493' residue . Dephosphorylates the immune system activator SKAP2 . Positively regulates toll-like receptor (TLR)-induced type 1 interferon production . Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy . Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 . Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity). .

AccessionsF5H2S8
ENST00000525799.1
ENST00000532224.5
ENST00000460620.5 [Q9Y2R2-5]
A0A0B4J1S7
ENST00000538253.5
ENST00000529045.1
E9PM87
A0A0A0MTD9
E9PMT0
ENST00000359785.10
Q9Y2R2
E9PMK2
A0A0A0MTE6
A0A1S6KJG4
ENST00000528414.5
ENST00000420377.6
G3K0T4