PPP3CA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097205Biological processrenal filtration
GO_0030216Biological processkeratinocyte differentiation
GO_0042104Biological processpositive regulation of activated T cell proliferation
GO_0071333Biological processcellular response to glucose stimulus
GO_1905205Biological processpositive regulation of connective tissue replacement
GO_0006470Biological processprotein dephosphorylation
GO_0008544Biological processepidermis development
GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0010629Biological processnegative regulation of gene expression
GO_0090193Biological processpositive regulation of glomerulus development
GO_0014898Biological processcardiac muscle hypertrophy in response to stress
GO_0048813Biological processdendrite morphogenesis
GO_0060079Biological processexcitatory postsynaptic potential
GO_0048741Biological processskeletal muscle fiber development
GO_0070886Biological processpositive regulation of calcineurin-NFAT signaling cascade
GO_0010628Biological processpositive regulation of gene expression
GO_0051592Biological processresponse to calcium ion
GO_0033173Biological processcalcineurin-NFAT signaling cascade
GO_0043403Biological processskeletal muscle tissue regeneration
GO_0045807Biological processpositive regulation of endocytosis
GO_0110062Biological processnegative regulation of angiotensin-activated signaling pathway
GO_0045785Biological processpositive regulation of cell adhesion
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0046676Biological processnegative regulation of insulin secretion
GO_0023057Biological processnegative regulation of signaling
GO_0042060Biological processwound healing
GO_0045672Biological processpositive regulation of osteoclast differentiation
GO_0014883Biological processtransition between fast and slow fiber
GO_0070262Biological processpeptidyl-serine dephosphorylation
GO_0030335Biological processpositive regulation of cell migration
GO_0033555Biological processmulticellular organismal response to stress
GO_0016311Biological processdephosphorylation
GO_0006606Biological processprotein import into nucleus
GO_0061006Biological processregulation of cell proliferation involved in kidney morphogenesis
GO_1905665Biological processpositive regulation of calcium ion import across plasma membrane
GO_0001975Biological processresponse to amphetamine
GO_0099170Biological processpostsynaptic modulation of chemical synaptic transmission
GO_0097720Biological processcalcineurin-mediated signaling
GO_0046878Biological processpositive regulation of saliva secretion
GO_0050774Biological processnegative regulation of dendrite morphogenesis
GO_0042110Biological processT cell activation
GO_0006816Biological processcalcium ion transport
GO_1903244Biological processpositive regulation of cardiac muscle hypertrophy in response to stress
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_1905949Biological processnegative regulation of calcium ion import across plasma membrane
GO_0098978Cellular componentglutamatergic synapse
GO_0036057Cellular componentslit diaphragm
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0005886Cellular componentplasma membrane
GO_0043197Cellular componentdendritic spine
GO_0030018Cellular componentZ disc
GO_0005739Cellular componentmitochondrion
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0019897Cellular componentextrinsic component of plasma membrane
GO_0042383Cellular componentsarcolemma
GO_0005654Cellular componentnucleoplasm
GO_0005955Cellular componentcalcineurin complex
GO_0005829Cellular componentcytosol
GO_0008287Cellular componentprotein serine/threonine phosphatase complex
GO_0005737Cellular componentcytoplasm
GO_0019899Molecular functionenzyme binding
GO_0017018Molecular functionmyosin phosphatase activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0051117Molecular functionATPase binding
GO_0004722Molecular functionprotein serine/threonine phosphatase activity
GO_0033192Molecular functioncalmodulin-dependent protein phosphatase activity
GO_0005516Molecular functioncalmodulin binding
GO_0005509Molecular functioncalcium ion binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding
GO_0016018Molecular functioncyclosporin A binding

IV. Literature review

[source]
Gene namePPP3CA
Protein nameProtein phosphatase 3 catalytic subunit alpha
Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform)
Serine/threonine-protein phosphatase (EC 3.1.3.16)
SynonymsCALNA
CNA
DescriptionFUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals . Many of the substrates contain a PxIxIT motif and/or a LxVP motif . In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation . In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion . Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 . In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation . Dephosphorylates and inactivates transcription factor ELK1 . Dephosphorylates DARPP32 . May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins . Dephosphorylates transcription factor TFEB at 'Ser-211' following Coxsackievirus B3 infection, promoting nuclear translocation . Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity). Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (By similarity). May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). Required for antigen-specific T-cell proliferation response (By similarity). Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4 . Negatively regulates SLC9A1 activity . .

AccessionsQ08209
ENST00000394854.8 [Q08209-1]
ENST00000512215.5 [Q08209-4]
E7ETC2
ENST00000525819.1
A0A0S2Z4B5
A0A0S2Z4C6
ENST00000507176.5
ENST00000492351.6
ENST00000323055.10 [Q08209-3]
H0YAB4
E9PK68
ENST00000529324.5
E9PPC8
ENST00000394853.8 [Q08209-2]