I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 12 studies | 30% ± 11% | |
| connective tissue cell | 6 studies | 31% ± 10% | |
| retinal pigment epithelial cell | 4 studies | 40% ± 15% | |
| mesothelial cell | 3 studies | 56% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 12 studies | 30% ± 11% | |
| connective tissue cell | 6 studies | 31% ± 10% | |
| retinal pigment epithelial cell | 4 studies | 40% ± 15% | |
| mesothelial cell | 3 studies | 56% ± 7% |
Insufficient scRNA-seq data for expression of BMP4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| intestine | 100% | 1531.97 | 965 / 966 | 97% | 78.91 | 510 / 527 |
| stomach | 100% | 1325.28 | 359 / 359 | 96% | 55.05 | 274 / 286 |
| prostate | 100% | 1912.42 | 245 / 245 | 80% | 11.70 | 403 / 502 |
| esophagus | 98% | 1068.55 | 1416 / 1445 | 74% | 22.84 | 135 / 183 |
| breast | 99% | 1196.74 | 454 / 459 | 67% | 15.84 | 744 / 1118 |
| bladder | 100% | 2323.29 | 21 / 21 | 64% | 33.86 | 325 / 504 |
| lung | 99% | 827.10 | 571 / 578 | 65% | 17.01 | 751 / 1155 |
| thymus | 99% | 758.00 | 644 / 653 | 61% | 12.62 | 367 / 605 |
| kidney | 91% | 550.24 | 81 / 89 | 67% | 13.60 | 604 / 901 |
| ovary | 100% | 1198.59 | 180 / 180 | 57% | 10.72 | 246 / 430 |
| uterus | 98% | 874.84 | 166 / 170 | 45% | 11.84 | 205 / 459 |
| adrenal gland | 97% | 1004.55 | 249 / 258 | 36% | 19.69 | 82 / 230 |
| pancreas | 32% | 87.76 | 105 / 328 | 93% | 44.40 | 166 / 178 |
| skin | 75% | 840.26 | 1356 / 1809 | 27% | 3.86 | 129 / 472 |
| adipose | 100% | 1110.43 | 1199 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1126.60 | 1329 / 1335 | 0% | 0 | 0 / 0 |
| heart | 97% | 714.52 | 839 / 861 | 0% | 0 | 0 / 0 |
| brain | 29% | 130.66 | 757 / 2642 | 62% | 6.68 | 434 / 705 |
| eye | 0% | 0 | 0 / 0 | 90% | 14.65 | 72 / 80 |
| muscle | 86% | 352.06 | 693 / 803 | 0% | 0 | 0 / 0 |
| liver | 41% | 110.12 | 93 / 226 | 42% | 10.59 | 170 / 406 |
| spleen | 77% | 322.77 | 186 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 36% | 2.86 | 16 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.20 | 1 / 29 |
| peripheral blood | 3% | 16.06 | 24 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006366 | Biological process | transcription by RNA polymerase II |
| GO_0060442 | Biological process | branching involved in prostate gland morphogenesis |
| GO_0001658 | Biological process | branching involved in ureteric bud morphogenesis |
| GO_0042476 | Biological process | odontogenesis |
| GO_0003014 | Biological process | renal system process |
| GO_0045786 | Biological process | negative regulation of cell cycle |
| GO_2000007 | Biological process | negative regulation of metanephric comma-shaped body morphogenesis |
| GO_0030225 | Biological process | macrophage differentiation |
| GO_0050918 | Biological process | positive chemotaxis |
| GO_0045662 | Biological process | negative regulation of myoblast differentiation |
| GO_0001656 | Biological process | metanephros development |
| GO_0002062 | Biological process | chondrocyte differentiation |
| GO_0042491 | Biological process | inner ear auditory receptor cell differentiation |
| GO_0042733 | Biological process | embryonic digit morphogenesis |
| GO_0060441 | Biological process | epithelial tube branching involved in lung morphogenesis |
| GO_0003149 | Biological process | membranous septum morphogenesis |
| GO_0060976 | Biological process | coronary vasculature development |
| GO_0010159 | Biological process | specification of animal organ position |
| GO_0033085 | Biological process | negative regulation of T cell differentiation in thymus |
| GO_0032331 | Biological process | negative regulation of chondrocyte differentiation |
| GO_0010453 | Biological process | regulation of cell fate commitment |
| GO_0030509 | Biological process | BMP signaling pathway |
| GO_0060592 | Biological process | mammary gland formation |
| GO_0030513 | Biological process | positive regulation of BMP signaling pathway |
| GO_0003323 | Biological process | type B pancreatic cell development |
| GO_1905312 | Biological process | positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis |
| GO_0048701 | Biological process | embryonic cranial skeleton morphogenesis |
| GO_0003163 | Biological process | sinoatrial node development |
| GO_0060235 | Biological process | lens induction in camera-type eye |
| GO_2000636 | Biological process | positive regulation of primary miRNA processing |
| GO_0060502 | Biological process | epithelial cell proliferation involved in lung morphogenesis |
| GO_0045778 | Biological process | positive regulation of ossification |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0030224 | Biological process | monocyte differentiation |
| GO_0060686 | Biological process | negative regulation of prostatic bud formation |
| GO_0070244 | Biological process | negative regulation of thymocyte apoptotic process |
| GO_0042475 | Biological process | odontogenesis of dentin-containing tooth |
| GO_0003277 | Biological process | apoptotic process involved in endocardial cushion morphogenesis |
| GO_0002244 | Biological process | hematopoietic progenitor cell differentiation |
| GO_0001657 | Biological process | ureteric bud development |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0009948 | Biological process | anterior/posterior axis specification |
| GO_0045839 | Biological process | negative regulation of mitotic nuclear division |
| GO_0071773 | Biological process | cellular response to BMP stimulus |
| GO_0048392 | Biological process | intermediate mesodermal cell differentiation |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_1901331 | Biological process | positive regulation of odontoblast differentiation |
| GO_0090194 | Biological process | negative regulation of glomerulus development |
| GO_0001649 | Biological process | osteoblast differentiation |
| GO_1902894 | Biological process | negative regulation of miRNA transcription |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0001822 | Biological process | kidney development |
| GO_0060391 | Biological process | positive regulation of SMAD protein signal transduction |
| GO_0061047 | Biological process | positive regulation of branching involved in lung morphogenesis |
| GO_0001958 | Biological process | endochondral ossification |
| GO_0045669 | Biological process | positive regulation of osteoblast differentiation |
| GO_1900745 | Biological process | positive regulation of p38MAPK cascade |
| GO_0001823 | Biological process | mesonephros development |
| GO_0050679 | Biological process | positive regulation of epithelial cell proliferation |
| GO_0032967 | Biological process | positive regulation of collagen biosynthetic process |
| GO_0007281 | Biological process | germ cell development |
| GO_0043068 | Biological process | positive regulation of programmed cell death |
| GO_0060425 | Biological process | lung morphogenesis |
| GO_0042487 | Biological process | regulation of odontogenesis of dentin-containing tooth |
| GO_0001843 | Biological process | neural tube closure |
| GO_0060503 | Biological process | bud dilation involved in lung branching |
| GO_0045843 | Biological process | negative regulation of striated muscle tissue development |
| GO_0072200 | Biological process | negative regulation of mesenchymal cell proliferation involved in ureter development |
| GO_0003184 | Biological process | pulmonary valve morphogenesis |
| GO_0072197 | Biological process | ureter morphogenesis |
| GO_2000005 | Biological process | negative regulation of metanephric S-shaped body morphogenesis |
| GO_0003007 | Biological process | heart morphogenesis |
| GO_0072125 | Biological process | negative regulation of glomerular mesangial cell proliferation |
| GO_0048745 | Biological process | smooth muscle tissue development |
| GO_0003215 | Biological process | cardiac right ventricle morphogenesis |
| GO_0045606 | Biological process | positive regulation of epidermal cell differentiation |
| GO_0003198 | Biological process | epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO_0003148 | Biological process | outflow tract septum morphogenesis |
| GO_0036305 | Biological process | ameloblast differentiation |
| GO_0060433 | Biological process | bronchus development |
| GO_0032092 | Biological process | positive regulation of protein binding |
| GO_0048661 | Biological process | positive regulation of smooth muscle cell proliferation |
| GO_0021978 | Biological process | telencephalon regionalization |
| GO_0060513 | Biological process | prostatic bud formation |
| GO_0003180 | Biological process | aortic valve morphogenesis |
| GO_1905072 | Biological process | cardiac jelly development |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0060440 | Biological process | trachea formation |
| GO_1905770 | Biological process | regulation of mesodermal cell differentiation |
| GO_0072104 | Biological process | glomerular capillary formation |
| GO_0007492 | Biological process | endoderm development |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0060363 | Biological process | cranial suture morphogenesis |
| GO_0090191 | Biological process | negative regulation of branching involved in ureteric bud morphogenesis |
| GO_0003197 | Biological process | endocardial cushion development |
| GO_0007500 | Biological process | mesodermal cell fate determination |
| GO_0072179 | Biological process | nephric duct formation |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0060687 | Biological process | regulation of branching involved in prostate gland morphogenesis |
| GO_1904238 | Biological process | pericyte cell differentiation |
| GO_0002320 | Biological process | lymphoid progenitor cell differentiation |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0061036 | Biological process | positive regulation of cartilage development |
| GO_0055020 | Biological process | positive regulation of cardiac muscle fiber development |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0048286 | Biological process | lung alveolus development |
| GO_0060438 | Biological process | trachea development |
| GO_0009791 | Biological process | post-embryonic development |
| GO_0035990 | Biological process | tendon cell differentiation |
| GO_1904706 | Biological process | negative regulation of vascular associated smooth muscle cell proliferation |
| GO_0045603 | Biological process | positive regulation of endothelial cell differentiation |
| GO_0048663 | Biological process | neuron fate commitment |
| GO_0055007 | Biological process | cardiac muscle cell differentiation |
| GO_0060449 | Biological process | bud elongation involved in lung branching |
| GO_1902893 | Biological process | regulation of miRNA transcription |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0021904 | Biological process | dorsal/ventral neural tube patterning |
| GO_0050680 | Biological process | negative regulation of epithelial cell proliferation |
| GO_0035116 | Biological process | embryonic hindlimb morphogenesis |
| GO_0060426 | Biological process | lung vasculature development |
| GO_0060272 | Biological process | embryonic skeletal joint morphogenesis |
| GO_0002043 | Biological process | blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| GO_0003279 | Biological process | cardiac septum development |
| GO_0030218 | Biological process | erythrocyte differentiation |
| GO_0003150 | Biological process | muscular septum morphogenesis |
| GO_0003129 | Biological process | heart induction |
| GO_0001938 | Biological process | positive regulation of endothelial cell proliferation |
| GO_0035993 | Biological process | deltoid tuberosity development |
| GO_0051145 | Biological process | smooth muscle cell differentiation |
| GO_2001237 | Biological process | negative regulation of extrinsic apoptotic signaling pathway |
| GO_0010718 | Biological process | positive regulation of epithelial to mesenchymal transition |
| GO_0060684 | Biological process | epithelial-mesenchymal cell signaling |
| GO_1904753 | Biological process | negative regulation of vascular associated smooth muscle cell migration |
| GO_0033088 | Biological process | negative regulation of immature T cell proliferation in thymus |
| GO_0021983 | Biological process | pituitary gland development |
| GO_0045666 | Biological process | positive regulation of neuron differentiation |
| GO_0003139 | Biological process | secondary heart field specification |
| GO_0061626 | Biological process | pharyngeal arch artery morphogenesis |
| GO_0030501 | Biological process | positive regulation of bone mineralization |
| GO_0042306 | Biological process | regulation of protein import into nucleus |
| GO_0051150 | Biological process | regulation of smooth muscle cell differentiation |
| GO_1900182 | Biological process | positive regulation of protein localization to nucleus |
| GO_0021537 | Biological process | telencephalon development |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005615 | Cellular component | extracellular space |
| GO_0042056 | Molecular function | chemoattractant activity |
| GO_0070700 | Molecular function | BMP receptor binding |
| GO_0005125 | Molecular function | cytokine activity |
| GO_0008201 | Molecular function | heparin binding |
| GO_0039706 | Molecular function | co-receptor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0008083 | Molecular function | growth factor activity |
| Gene name | BMP4 |
| Protein name | Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B) Bone morphogenetic protein 4 preproprotein Bone morphogenetic protein 4 Alternative protein BMP4 |
| Synonyms | hCG_20967 DVR4 BMP2B |
| Description | FUNCTION: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis . Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 . Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes . Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus (By similarity). Required for MSX1-mediated mesenchymal molar tooth bud development beyond the bud stage, via promoting Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades . For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response . . |
| Accessions | U3MVU6 ENST00000559501.1 H0YLW3 A0A1B1PFV3 Q53XC5 A0A097PIE4 H0YM53 A0A097PIG0 L8E8S7 ENST00000558984.1 ENST00000559642.1 A0A140G956 A0A1B1PFV8 H0YMP9 V9GYF1 P12644 ENST00000245451.9 ENST00000558961.1 ENST00000609748.1 ENST00000417573.5 ENST00000559087.5 |
