PARP14 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	40 studies	33% ± 12%	Explore
B cell	34 studies	32% ± 11%	Explore
macrophage	30 studies	32% ± 14%	Explore
natural killer cell	21 studies	22% ± 5%	Explore
non-classical monocyte	20 studies	25% ± 9%	Explore
memory B cell	19 studies	27% ± 7%	Explore
naive B cell	19 studies	35% ± 10%	Explore
classical monocyte	18 studies	26% ± 10%	Explore
monocyte	15 studies	32% ± 10%	Explore
ciliated cell	14 studies	31% ± 14%	Explore
capillary endothelial cell	13 studies	30% ± 7%	Explore
dendritic cell	12 studies	28% ± 11%	Explore
fibroblast	12 studies	22% ± 5%	Explore
endothelial cell of artery	12 studies	26% ± 8%	Explore
myeloid cell	12 studies	30% ± 12%	Explore
type I pneumocyte	11 studies	49% ± 16%	Explore
microglial cell	11 studies	37% ± 15%	Explore
vein endothelial cell	11 studies	25% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	21% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	21% ± 4%	Explore
CD8-positive, alpha-beta T cell	9 studies	20% ± 4%	Explore
conventional dendritic cell	9 studies	24% ± 12%	Explore
pericyte	9 studies	19% ± 3%	Explore
basal cell	9 studies	22% ± 4%	Explore
T cell	8 studies	25% ± 7%	Explore
endothelial cell of lymphatic vessel	8 studies	26% ± 7%	Explore
type II pneumocyte	8 studies	33% ± 10%	Explore
epithelial cell	8 studies	35% ± 21%	Explore
endothelial cell of vascular tree	8 studies	26% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	18% ± 2%	Explore
club cell	7 studies	35% ± 15%	Explore
alveolar macrophage	6 studies	35% ± 14%	Explore
leukocyte	6 studies	28% ± 6%	Explore
regulatory T cell	6 studies	18% ± 2%	Explore
mononuclear phagocyte	5 studies	28% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	21% ± 6%	Explore
mature NK T cell	5 studies	23% ± 6%	Explore
lymphocyte	5 studies	29% ± 8%	Explore
gamma-delta T cell	5 studies	21% ± 4%	Explore
oligodendrocyte precursor cell	5 studies	28% ± 10%	Explore
respiratory goblet cell	4 studies	36% ± 10%	Explore
secretory cell	4 studies	29% ± 7%	Explore
ionocyte	3 studies	17% ± 0%	Explore
neutrophil	3 studies	15% ± 0%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
CD4-positive, alpha-beta T cell	3 studies	19% ± 3%	Explore
glomerular endothelial cell	3 studies	43% ± 1%	Explore
precursor B cell	3 studies	24% ± 9%	Explore
tissue-resident macrophage	3 studies	33% ± 8%	Explore
abnormal cell	3 studies	23% ± 4%	Explore
intermediate monocyte	3 studies	34% ± 20%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	18% ± 1%	Explore
immature B cell	3 studies	29% ± 2%	Explore
astrocyte	3 studies	27% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	13 studies	25% ± 8%	Explore
peripheral blood	10 studies	24% ± 9%	Explore
liver	3 studies	24% ± 7%	Explore
brain	3 studies	20% ± 3%	Explore
adipose	3 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3959.98	1444 / 1445	100%	61.00	183 / 183
lung	100%	15242.85	578 / 578	99%	51.05	1145 / 1155
thymus	100%	7490.21	653 / 653	98%	53.28	594 / 605
stomach	100%	3322.43	359 / 359	98%	37.51	279 / 286
breast	100%	5612.06	459 / 459	97%	50.76	1087 / 1118
uterus	100%	4815.02	170 / 170	97%	51.11	443 / 459
kidney	100%	6137.17	89 / 89	96%	44.27	868 / 901
intestine	100%	5555.80	966 / 966	95%	33.41	503 / 527
ovary	100%	4217.80	180 / 180	95%	37.85	407 / 430
bladder	100%	4064.14	21 / 21	94%	38.63	476 / 504
liver	100%	4662.55	226 / 226	93%	25.60	376 / 406
prostate	100%	6045.30	245 / 245	92%	23.65	464 / 502
pancreas	95%	2111.63	312 / 328	97%	40.55	172 / 178
skin	96%	2718.94	1742 / 1809	89%	36.43	418 / 472
adrenal gland	100%	5392.53	258 / 258	60%	9.66	138 / 230
brain	76%	1550.12	2014 / 2642	81%	19.71	573 / 705
adipose	100%	6502.03	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	57.18	29 / 29
spleen	100%	16684.56	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	70.38	45 / 45
blood vessel	99%	3497.98	1316 / 1335	0%	0	0 / 0
heart	98%	2498.07	842 / 861	0%	0	0 / 0
peripheral blood	97%	9131.09	900 / 929	0%	0	0 / 0
muscle	80%	1293.33	644 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	30%	5.60	24 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0042531	Biological process	positive regulation of tyrosine phosphorylation of STAT protein
GO_0010629	Biological process	negative regulation of gene expression
GO_0045087	Biological process	innate immune response
GO_0060336	Biological process	negative regulation of type II interferon-mediated signaling pathway
GO_0070212	Biological process	protein poly-ADP-ribosylation
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0042532	Biological process	negative regulation of tyrosine phosphorylation of STAT protein
GO_1902216	Biological process	positive regulation of interleukin-4-mediated signaling pathway
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0016779	Molecular function	nucleotidyltransferase activity
GO_0019899	Molecular function	enzyme binding
GO_0003950	Molecular function	NAD+ ADP-ribosyltransferase activity
GO_0003714	Molecular function	transcription corepressor activity
GO_1990404	Molecular function	NAD+-protein ADP-ribosyltransferase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PARP14
Protein name	Protein mono-ADP-ribosyltransferase PARP14 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) (Poly [ADP-ribose] polymerase 14) (PARP-14) PARP14 protein Poly(ADP-ribose) polymerase family member 14
Synonyms	KIAA1268 BAL2
Description	FUNCTION: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins . In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation . Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation . However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' . Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription . In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation . Mono-ADP-ribosylates PARP9 . .
Accessions	ENST00000649945.1 ENST00000460683.1 H7C5R8 Q460N5 A0A3B3ITD5 ENST00000494811.2 Q8N546 H7C4Y3 ENST00000474629.7 [Q460N5-6]

PARP14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review