PICALM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016188Biological processsynaptic vesicle maturation
GO_1902003Biological processregulation of amyloid-beta formation
GO_0031623Biological processreceptor internalization
GO_0035459Biological processvesicle cargo loading
GO_0097753Biological processmembrane bending
GO_0030097Biological processhemopoiesis
GO_0006897Biological processendocytosis
GO_0010629Biological processnegative regulation of gene expression
GO_0006898Biological processreceptor-mediated endocytosis
GO_0007611Biological processlearning or memory
GO_0097494Biological processregulation of vesicle size
GO_0048813Biological processdendrite morphogenesis
GO_0032880Biological processregulation of protein localization
GO_0060586Biological processmulticellular organismal-level iron ion homeostasis
GO_0016185Biological processsynaptic vesicle budding from presynaptic endocytic zone membrane
GO_0065003Biological processprotein-containing complex assembly
GO_0007409Biological processaxonogenesis
GO_0016192Biological processvesicle-mediated transport
GO_0048268Biological processclathrin coat assembly
GO_0016197Biological processendosomal transport
GO_0150093Biological processamyloid-beta clearance by transcytosis
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006879Biological processintracellular iron ion homeostasis
GO_1902004Biological processpositive regulation of amyloid-beta formation
GO_1902993Biological processpositive regulation of amyloid precursor protein catabolic process
GO_2000009Biological processnegative regulation of protein localization to cell surface
GO_0006900Biological processvesicle budding from membrane
GO_0030100Biological processregulation of endocytosis
GO_0048261Biological processnegative regulation of receptor-mediated endocytosis
GO_0046579Biological processpositive regulation of Ras protein signal transduction
GO_0072583Biological processclathrin-dependent endocytosis
GO_1902991Biological processregulation of amyloid precursor protein catabolic process
GO_1903077Biological processnegative regulation of protein localization to plasma membrane
GO_0097418Cellular componentneurofibrillary tangle
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005794Cellular componentGolgi apparatus
GO_0043025Cellular componentneuronal cell body
GO_0098894Cellular componentextrinsic component of presynaptic endocytic zone membrane
GO_0042734Cellular componentpresynaptic membrane
GO_0009986Cellular componentcell surface
GO_0070381Cellular componentendosome to plasma membrane transport vesicle
GO_0005829Cellular componentcytosol
GO_0008021Cellular componentsynaptic vesicle
GO_0030132Cellular componentclathrin coat of coated pit
GO_0045334Cellular componentclathrin-coated endocytic vesicle
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0045211Cellular componentpostsynaptic membrane
GO_0005905Cellular componentclathrin-coated pit
GO_0031982Cellular componentvesicle
GO_0005634Cellular componentnucleus
GO_0032050Molecular functionclathrin heavy chain binding
GO_0045296Molecular functioncadherin binding
GO_0001540Molecular functionamyloid-beta binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0031267Molecular functionsmall GTPase binding
GO_0050750Molecular functionlow-density lipoprotein particle receptor binding
GO_0005545Molecular function1-phosphatidylinositol binding
GO_0000149Molecular functionSNARE binding
GO_0030276Molecular functionclathrin binding
GO_0048156Molecular functiontau protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePICALM
Protein namePhosphatidylinositol binding clathrin assembly protein
Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein)
Alternative protein PICALM
Phosphatidylinositol-binding clathrin assembly protein isoform 2
SynonymsCALM
DescriptionFUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly . Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature . In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 . In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors . Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) . .

AccessionsENST00000393346.8 [Q13492-1]
ENST00000528256.1
B5BU72
ENST00000525162.5
E9PK13
ENST00000532041.5
ENST00000529016.5
H0YE97
E9PLJ8
ENST00000531930.5
ENST00000534412.5
ENST00000532603.5
E9PI56
ENST00000532317.5 [Q13492-3]
ENST00000529760.5
E9PKP6
H0YEF7
H0YEH1
L8ECD8
ENST00000530692.5
ENST00000630913.2
H0YD48
H0YCY1
E9PJT1
ENST00000530542.1
Q13492
ENST00000356360.9 [Q13492-2]
ENST00000526961.5
H0YEY8
ENST00000531558.1
ENST00000526033.5 [Q13492-5]
ENST00000528398.5 [Q13492-4]