SMAD5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0003161Biological processcardiac conduction system development
GO_0001657Biological processureteric bud development
GO_0002051Biological processosteoblast fate commitment
GO_0010629Biological processnegative regulation of gene expression
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0001649Biological processosteoblast differentiation
GO_0007165Biological processsignal transduction
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0060048Biological processcardiac muscle contraction
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0030509Biological processBMP signaling pathway
GO_0030218Biological processerythrocyte differentiation
GO_0060395Biological processSMAD protein signal transduction
GO_0009880Biological processembryonic pattern specification
GO_1902045Biological processnegative regulation of Fas signaling pathway
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0007281Biological processgerm cell development
GO_0030154Biological processcell differentiation
GO_0001880Biological processMullerian duct regression
GO_0009653Biological processanatomical structure morphogenesis
GO_0060348Biological processbone development
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0051216Biological processcartilage development
GO_0071407Biological processcellular response to organic cyclic compound
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0071141Cellular componentSMAD protein complex
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0071144Cellular componentheteromeric SMAD protein complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046872Molecular functionmetal ion binding
GO_0017151Molecular functionDEAD/H-box RNA helicase binding
GO_0070411Molecular functionI-SMAD binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSMAD5
Protein nameSMAD family member 5
Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5)
SynonymsDKFZp781O1323
hCG_41402
DKFZp781C1895
MADH5
DescriptionFUNCTION: Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis . Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form an heteromeric complex which translocates into the nucleus acting as transcription factor . In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network . Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes . Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis . .

AccessionsD6RBB4
ENST00000509297.6
ENST00000513418.1
ENST00000511116.5
H0YAM3
ENST00000545279.6
H0YAK7
D6R9D4
Q68DB7
ENST00000507637.1
ENST00000507118.5
ENST00000506223.1
D6RIZ9
ENST00000545620.5
Q99717