NDFIP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051224Biological processnegative regulation of protein transport
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0007034Biological processvacuolar transport
GO_0032410Biological processnegative regulation of transporter activity
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0030001Biological processmetal ion transport
GO_0010629Biological processnegative regulation of gene expression
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005794Cellular componentGolgi apparatus
GO_0032585Cellular componentmultivesicular body membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005515Molecular functionprotein binding
GO_0050699Molecular functionWW domain binding

IV. Literature review

[source]
Gene nameNDFIP2
Protein nameNEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413)
Nedd4 family interacting protein 2
Nedd4 family interacting protein 2 (cDNA FLJ53039, highly similar to NEDD4 family-interacting protein 2)
SynonymsN4WBP5A
KIAA1165
DescriptionFUNCTION: Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation . May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). .

AccessionsENST00000703149.1
A0A8V8TQ57
ENST00000703151.1
ENST00000487865.5
A0A8V8TQ62
ENST00000703152.1
ENST00000465762.6
ENST00000703153.1
ENST00000703126.1
A0A8V8TQM3
ENST00000703150.1
ENST00000703154.1
A0A3B3IRK3
A0A8V8TQP7
ENST00000620924.1
ENST00000703145.1
A0A8V8TQQ2
A0A8V8TQN2
A0A8V8TR80
A0A8V8TQ43
ENST00000703147.1
ENST00000218652.12
ENST00000650134.1
ENST00000703155.1
ENST00000703125.1
A0A8V8TRG3
A0A8V8TRH4
H7C5F7
A0A0C4DGW0
ENST00000703146.1
ENST00000703122.1
Q9NV92
ENST00000703123.1
A0A8V8TRH3
ENST00000703121.1
B4DGY6
A0A8V8TQN7