Name | Number of supported studies | Average coverage | |
---|---|---|---|
basal cell | 13 studies | 34% ± 19% | |
ciliated cell | 12 studies | 31% ± 13% | |
oligodendrocyte | 10 studies | 28% ± 9% | |
glutamatergic neuron | 9 studies | 54% ± 23% | |
regulatory T cell | 9 studies | 20% ± 4% | |
mast cell | 8 studies | 25% ± 8% | |
endothelial cell | 8 studies | 22% ± 8% | |
epithelial cell | 8 studies | 39% ± 20% | |
goblet cell | 5 studies | 29% ± 13% | |
enterocyte | 5 studies | 24% ± 3% | |
squamous epithelial cell | 4 studies | 43% ± 17% | |
epithelial cell of proximal tubule | 4 studies | 16% ± 1% | |
neuron | 4 studies | 32% ± 6% | |
type I pneumocyte | 4 studies | 21% ± 4% | |
GABAergic neuron | 4 studies | 40% ± 15% | |
keratinocyte | 4 studies | 32% ± 17% | |
CD8-positive, alpha-beta T cell | 4 studies | 25% ± 3% | |
extravillous trophoblast | 3 studies | 27% ± 6% | |
placental villous trophoblast | 3 studies | 23% ± 4% | |
rod bipolar cell | 3 studies | 24% ± 4% | |
oligodendrocyte precursor cell | 3 studies | 22% ± 4% | |
pancreatic ductal cell | 3 studies | 41% ± 17% | |
mesothelial cell | 3 studies | 30% ± 15% | |
secretory cell | 3 studies | 32% ± 12% | |
astrocyte | 3 studies | 28% ± 13% | |
CD4-positive, alpha-beta cytotoxic T cell | 3 studies | 21% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
stomach | 99% | 1510.82 | 356 / 359 | 100% | 63.88 | 286 / 286 |
brain | 99% | 3237.42 | 2611 / 2642 | 100% | 39.31 | 705 / 705 |
kidney | 100% | 2185.96 | 89 / 89 | 99% | 46.01 | 889 / 901 |
lung | 99% | 1664.76 | 571 / 578 | 100% | 37.72 | 1152 / 1155 |
pancreas | 99% | 1512.81 | 324 / 328 | 99% | 33.93 | 177 / 178 |
breast | 100% | 1395.59 | 459 / 459 | 98% | 25.87 | 1091 / 1118 |
intestine | 98% | 2201.28 | 946 / 966 | 100% | 69.60 | 525 / 527 |
prostate | 98% | 1399.95 | 241 / 245 | 99% | 31.60 | 497 / 502 |
thymus | 99% | 1209.43 | 646 / 653 | 98% | 25.08 | 591 / 605 |
bladder | 95% | 1706.48 | 20 / 21 | 98% | 57.55 | 495 / 504 |
skin | 100% | 5875.01 | 1809 / 1809 | 91% | 27.55 | 429 / 472 |
adrenal gland | 100% | 1913.28 | 258 / 258 | 91% | 19.67 | 209 / 230 |
esophagus | 91% | 2223.11 | 1308 / 1445 | 99% | 59.12 | 182 / 183 |
uterus | 93% | 802.02 | 158 / 170 | 96% | 44.62 | 440 / 459 |
liver | 100% | 1667.96 | 226 / 226 | 88% | 16.90 | 357 / 406 |
ovary | 85% | 728.72 | 153 / 180 | 100% | 29.62 | 429 / 430 |
ureter | 0% | 0 | 0 / 0 | 100% | 10.63 | 1 / 1 |
muscle | 100% | 2052.68 | 800 / 803 | 0% | 0 | 0 / 0 |
adipose | 100% | 1440.43 | 1198 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 39.56 | 43 / 45 |
blood vessel | 92% | 871.10 | 1224 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 90% | 15.98 | 26 / 29 |
heart | 89% | 1366.17 | 766 / 861 | 0% | 0 | 0 / 0 |
spleen | 86% | 768.63 | 208 / 241 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 63% | 9.59 | 50 / 80 |
peripheral blood | 19% | 450.92 | 176 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0051224 | Biological process | negative regulation of protein transport |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0031398 | Biological process | positive regulation of protein ubiquitination |
GO_0007034 | Biological process | vacuolar transport |
GO_0032410 | Biological process | negative regulation of transporter activity |
GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
GO_0030001 | Biological process | metal ion transport |
GO_0010629 | Biological process | negative regulation of gene expression |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0000139 | Cellular component | Golgi membrane |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0032585 | Cellular component | multivesicular body membrane |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0005737 | Cellular component | cytoplasm |
GO_0005739 | Cellular component | mitochondrion |
GO_0005515 | Molecular function | protein binding |
GO_0050699 | Molecular function | WW domain binding |
Gene name | NDFIP2 |
Protein name | NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413) Nedd4 family interacting protein 2 Nedd4 family interacting protein 2 (cDNA FLJ53039, highly similar to NEDD4 family-interacting protein 2) |
Synonyms | N4WBP5A KIAA1165 |
Description | FUNCTION: Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation . May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). . |
Accessions | ENST00000703149.1 A0A8V8TQ57 ENST00000703151.1 ENST00000487865.5 A0A8V8TQ62 ENST00000703152.1 ENST00000465762.6 ENST00000703153.1 ENST00000703126.1 A0A8V8TQM3 ENST00000703150.1 ENST00000703154.1 A0A3B3IRK3 A0A8V8TQP7 ENST00000620924.1 ENST00000703145.1 A0A8V8TQQ2 A0A8V8TQN2 A0A8V8TR80 A0A8V8TQ43 ENST00000703147.1 ENST00000218652.12 ENST00000650134.1 ENST00000703155.1 ENST00000703125.1 A0A8V8TRG3 A0A8V8TRH4 H7C5F7 A0A0C4DGW0 ENST00000703146.1 ENST00000703122.1 Q9NV92 ENST00000703123.1 A0A8V8TRH3 ENST00000703121.1 B4DGY6 A0A8V8TQN7 |