FOXP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0033574Biological processresponse to testosterone
GO_0010468Biological processregulation of gene expression
GO_0032680Biological processregulation of tumor necrosis factor production
GO_0042116Biological processmacrophage activation
GO_0032655Biological processregulation of interleukin-12 production
GO_1900424Biological processregulation of defense response to bacterium
GO_1901509Biological processregulation of endothelial tube morphogenesis
GO_0042117Biological processmonocyte activation
GO_0010629Biological processnegative regulation of gene expression
GO_0030316Biological processosteoclast differentiation
GO_1901300Biological processpositive regulation of hydrogen peroxide-mediated programmed cell death
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0032745Biological processpositive regulation of interleukin-21 production
GO_0006974Biological processDNA damage response
GO_0002903Biological processnegative regulation of B cell apoptotic process
GO_2000341Biological processregulation of chemokine (C-X-C motif) ligand 2 production
GO_0050861Biological processpositive regulation of B cell receptor signaling pathway
GO_0021756Biological processstriatum development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0050727Biological processregulation of inflammatory response
GO_0042118Biological processendothelial cell activation
GO_1901256Biological processregulation of macrophage colony-stimulating factor production
GO_0061052Biological processnegative regulation of cell growth involved in cardiac muscle cell development
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0032651Biological processregulation of interleukin-1 beta production
GO_0061470Biological processT follicular helper cell differentiation
GO_0060766Biological processnegative regulation of androgen receptor signaling pathway
GO_0045655Biological processregulation of monocyte differentiation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0036035Biological processosteoclast development
GO_0032496Biological processresponse to lipopolysaccharide
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001046Molecular functioncore promoter sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0046872Molecular functionmetal ion binding
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFOXP1
Protein nameForkhead box protein P1
Forkhead box P1
12CC4 (Forkhead box P1, isoform CRA_a)
Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH)
Forkhead box P1 (Forkhead box protein P1)
FOXP1 protein
SynonymshCG_1778483
HSPC215
DescriptionFUNCTION: Transcriptional repressor . Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis . Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor . Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B . Can negatively regulate androgen receptor signaling . Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA . .; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) . Promotes ESC self-renewal and pluripotency (By similarity). .

AccessionsQ6IAJ1
ENST00000650188.1
A0A0B4J2F3
ENST00000491238.8
C9IYY1
ENST00000493089.7 [Q9H334-7]
ENST00000648718.1 [Q9H334-7]
A0A3B3IT14
A0A3B3IRW5
A0A3B3IS87
ENST00000650387.1
ENST00000648654.1
ENST00000318779.7 [Q9H334-5]
ENST00000497553.4
ENST00000648321.1
ENST00000650068.2 [Q9H334-1]
ENST00000650295.1
ENST00000648710.2 [Q9H334-7]
A0A3B3ISQ7
ENST00000650402.1
ENST00000648895.1
ENST00000648426.1 [Q9H334-8]
H0Y882
ENST00000485326.7
A0A3B3IST6
ENST00000484350.5 [Q9H334-6]
ENST00000649631.1 [Q9H334-1]
ENST00000648783.1
A0A3B3IT66
Q548T7
G5E965
ENST00000614176.5
ENST00000472382.7
A3KMG1
ENST00000650068
ENST00000648794.2
ENST00000649528.3 [Q9H334-1]
ENST00000498215.7 [Q9H334-1]
ENST00000475937.6
A0A3B3IST0
A0A087X2G3
Q9H334
ENST00000468577.6
A0A3B3IRL7
A0A3B3ITZ4
ENST00000649610.2
ENST00000318789.11 [Q9H334-1]
ENST00000649592.1
A0A3B3IU15
ENST00000650156.1
ENST00000648748.3
ENST00000327590.9
A0A3B3IRS5
A0A3B3IU08
ENST00000649596.1
C9J5T4
A0A3B3ISA4
ENST00000497355.7
ENST00000471386.3
ENST00000648384.1
ENST00000648710
A0A3B3IT26
C9J0F0
A0A3B3IRY1
ENST00000647614.1
ENST00000649695.3
ENST00000649513.1
ENST00000649431.2
ENST00000648380.1 [Q9H334-1]
A0A3B3IUB6