KDM4A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010468Biological processregulation of gene expression
GO_0010629Biological processnegative regulation of gene expression
GO_0014898Biological processcardiac muscle hypertrophy in response to stress
GO_0010628Biological processpositive regulation of gene expression
GO_0048712Biological processnegative regulation of astrocyte differentiation
GO_0006338Biological processchromatin remodeling
GO_0030263Biological processapoptotic chromosome condensation
GO_0031667Biological processresponse to nutrient levels
GO_0010507Biological processnegative regulation of autophagy
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0005829Cellular componentcytosol
GO_0005721Cellular componentpericentric heterochromatin
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0032454Molecular functionhistone H3K9 demethylase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0140681Molecular functionhistone H3K36me2/H3K36me3 demethylase activity
GO_0032452Molecular functionhistone demethylase activity
GO_0008270Molecular functionzinc ion binding
GO_0140684Molecular functionhistone H3K9me2/H3K9me3 demethylase activity
GO_0005515Molecular functionprotein binding
GO_0051864Molecular functionhistone H3K36 demethylase activity

IV. Literature review

[source]
Gene nameKDM4A
Protein nameLysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A)
Alternative protein KDM4A
Lysine demethylase 4A
SynonymsKIAA0677
JHDM3A
JMJD2
JMJD2A
DescriptionFUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code . Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. .; FUNCTION: [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. .

AccessionsA0A2R8Y7L1
ENST00000485249.1
L8ECF0
ENST00000372396.4 [O75164-1]
A0A2R8YDF7
ENST00000463151.5
O75164