TRIM6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRIM6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM6 at tissue level.

III. Associated gene sets

GO_2000679Biological processpositive regulation of transcription regulatory region DNA binding
GO_1901222Biological processregulation of non-canonical NF-kappaB signal transduction
GO_0045071Biological processnegative regulation of viral genome replication
GO_0000209Biological processprotein polyubiquitination
GO_0060340Biological processpositive regulation of type I interferon-mediated signaling pathway
GO_0010629Biological processnegative regulation of gene expression
GO_0045087Biological processinnate immune response
GO_0002720Biological processpositive regulation of cytokine production involved in immune response
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0032880Biological processregulation of protein localization
GO_0010994Biological processfree ubiquitin chain polymerization
GO_0035458Biological processcellular response to interferon-beta
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0098586Biological processcellular response to virus
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0010508Biological processpositive regulation of autophagy
GO_2000737Biological processnegative regulation of stem cell differentiation
GO_0010800Biological processpositive regulation of peptidyl-threonine phosphorylation
GO_0002230Biological processpositive regulation of defense response to virus by host
GO_0046596Biological processregulation of viral entry into host cell
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0032496Biological processresponse to lipopolysaccharide
GO_0140374Biological processantiviral innate immune response
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_1990782Molecular functionprotein tyrosine kinase binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIM6
Protein nameTripartite motif-containing protein 6 (EC 2.3.2.27) (RING finger protein 89) (RING-type E3 ubiquitin transferase TRIM6)
TRIM6 protein
Tripartite motif containing 6
SynonymsRNF89
DescriptionFUNCTION: E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway . In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response . Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Promotes the association of unanchored 'Lys-48'-polyubiquitin chains with DHX16 leading to enhanced RIGI-mediated innate antiviral immune response . .; FUNCTION: (Microbial infection) Ubiquitinates ebolavirus protein VP35 leading to enhanced viral transcriptase activity. .

AccessionsENST00000507320.5 [Q9C030-3]
ENST00000380107.5
ENST00000445329.5 [Q9C030-3]
ENST00000515022.5 [Q9C030-3]
C9JNQ0
E9PFM0
ENST00000506134.5 [Q9C030-3]
ENST00000380097.8 [Q9C030-2]
ENST00000621176.1
Q6P0L0
Q9C030
ENST00000424369.5
ENST00000278302.9 [Q9C030-1]