ZNF808 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030154Biological processcell differentiation
GO_0031016Biological processpancreas development
GO_0010629Biological processnegative regulation of gene expression
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0046872Molecular functionmetal ion binding
GO_0000976Molecular functiontranscription cis-regulatory region binding

IV. Literature review

[source]
Gene nameZNF808
Protein nameZNF808 protein
Zinc finger protein 808
Synonyms
DescriptionFUNCTION: Transcriptional repressor that targets mainly transposable elements . Primarily targets the long terminal repeat of endogenous retroviruses classified as MER11 elements which comprise subfamilies A, B and C . May silence transposable elements through the establishment of heterochromatin-associated trimethylation of 'Lys-9' of histone H3 (H3K9me3) . Can also bind to certain gene promoters and other genomic regions . Represses transcription of specific MER11 elements during differentiation toward pancreatic lineages in early pancreas development . By repressing transcription, prevents a liver gene expression program from being aberrantly activated during pancreas differentiation . .

AccessionsC9IZE3
C9JVX0
C9J0J5
C1K3N6
ENST00000486474.5
ENST00000487863.5 [Q8N4W9-2]
Q8N4W9
C9J871
ENST00000465448.5
ENST00000461321.1
ENST00000359798.9 [Q8N4W9-1]
ENST00000461779.5
Q7Z749