I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 10 studies | 24% ± 7% | |
| endothelial cell | 5 studies | 21% ± 5% | |
| smooth muscle cell | 4 studies | 20% ± 5% | |
| Mueller cell | 3 studies | 20% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| pericyte | 10 studies | 24% ± 7% | |
| endothelial cell | 5 studies | 21% ± 5% | |
| smooth muscle cell | 4 studies | 20% ± 5% | |
| Mueller cell | 3 studies | 20% ± 2% |
Insufficient scRNA-seq data for expression of HEY2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 93% | 569.06 | 2447 / 2642 | 98% | 36.33 | 692 / 705 |
| ovary | 96% | 697.02 | 172 / 180 | 92% | 37.20 | 395 / 430 |
| thymus | 90% | 422.59 | 585 / 653 | 89% | 24.00 | 540 / 605 |
| breast | 94% | 785.49 | 430 / 459 | 71% | 12.32 | 794 / 1118 |
| liver | 88% | 318.45 | 199 / 226 | 53% | 4.37 | 214 / 406 |
| uterus | 92% | 661.22 | 156 / 170 | 43% | 9.05 | 197 / 459 |
| kidney | 51% | 184.67 | 45 / 89 | 77% | 13.13 | 693 / 901 |
| prostate | 57% | 239.11 | 140 / 245 | 53% | 5.04 | 267 / 502 |
| lung | 80% | 381.02 | 463 / 578 | 29% | 2.65 | 333 / 1155 |
| skin | 35% | 135.77 | 631 / 1809 | 69% | 11.61 | 325 / 472 |
| pancreas | 57% | 181.84 | 188 / 328 | 45% | 3.55 | 80 / 178 |
| blood vessel | 100% | 5974.47 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 1151.88 | 802 / 803 | 0% | 0 | 0 / 0 |
| esophagus | 58% | 213.22 | 839 / 1445 | 42% | 3.09 | 76 / 183 |
| heart | 96% | 1384.04 | 827 / 861 | 0% | 0 | 0 / 0 |
| bladder | 76% | 321.48 | 16 / 21 | 12% | 0.98 | 61 / 504 |
| adipose | 87% | 657.06 | 1047 / 1204 | 0% | 0 | 0 / 0 |
| intestine | 65% | 262.45 | 625 / 966 | 16% | 1.01 | 84 / 527 |
| stomach | 43% | 138.31 | 153 / 359 | 31% | 2.35 | 88 / 286 |
| tonsil | 0% | 0 | 0 / 0 | 56% | 3.93 | 25 / 45 |
| adrenal gland | 10% | 25.63 | 27 / 258 | 33% | 3.16 | 77 / 230 |
| spleen | 37% | 101.84 | 89 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 0.53 | 3 / 29 |
| eye | 0% | 0 | 0 / 0 | 9% | 0.86 | 7 / 80 |
| peripheral blood | 1% | 2.47 | 8 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0055015 | Biological process | ventricular cardiac muscle cell development |
| GO_2000723 | Biological process | negative regulation of cardiac vascular smooth muscle cell differentiation |
| GO_0065004 | Biological process | protein-DNA complex assembly |
| GO_0003161 | Biological process | cardiac conduction system development |
| GO_0035910 | Biological process | ascending aorta morphogenesis |
| GO_0009948 | Biological process | anterior/posterior axis specification |
| GO_0003151 | Biological process | outflow tract morphogenesis |
| GO_0003198 | Biological process | epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0014898 | Biological process | cardiac muscle hypertrophy in response to stress |
| GO_0045607 | Biological process | regulation of inner ear auditory receptor cell differentiation |
| GO_0060045 | Biological process | positive regulation of cardiac muscle cell proliferation |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0060411 | Biological process | cardiac septum morphogenesis |
| GO_0060347 | Biological process | heart trabecula formation |
| GO_0001570 | Biological process | vasculogenesis |
| GO_0003180 | Biological process | aortic valve morphogenesis |
| GO_0003195 | Biological process | tricuspid valve formation |
| GO_0060413 | Biological process | atrial septum morphogenesis |
| GO_0097084 | Biological process | vascular associated smooth muscle cell development |
| GO_0003199 | Biological process | endocardial cushion to mesenchymal transition involved in heart valve formation |
| GO_0072359 | Biological process | circulatory system development |
| GO_0003214 | Biological process | cardiac left ventricle morphogenesis |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0003215 | Biological process | cardiac right ventricle morphogenesis |
| GO_0051151 | Biological process | negative regulation of smooth muscle cell differentiation |
| GO_0060317 | Biological process | cardiac epithelial to mesenchymal transition |
| GO_0003208 | Biological process | cardiac ventricle morphogenesis |
| GO_2001212 | Biological process | regulation of vasculogenesis |
| GO_0014031 | Biological process | mesenchymal cell development |
| GO_0060038 | Biological process | cardiac muscle cell proliferation |
| GO_0070168 | Biological process | negative regulation of biomineral tissue development |
| GO_0003150 | Biological process | muscular septum morphogenesis |
| GO_0060633 | Biological process | negative regulation of transcription initiation by RNA polymerase II |
| GO_2000678 | Biological process | negative regulation of transcription regulatory region DNA binding |
| GO_0045165 | Biological process | cell fate commitment |
| GO_0090102 | Biological process | cochlea development |
| GO_0035912 | Biological process | dorsal aorta morphogenesis |
| GO_0060716 | Biological process | labyrinthine layer blood vessel development |
| GO_0060948 | Biological process | cardiac vascular smooth muscle cell development |
| GO_0051145 | Biological process | smooth muscle cell differentiation |
| GO_0010659 | Biological process | cardiac muscle cell apoptotic process |
| GO_0060412 | Biological process | ventricular septum morphogenesis |
| GO_0061156 | Biological process | pulmonary artery morphogenesis |
| GO_0009952 | Biological process | anterior/posterior pattern specification |
| GO_0060842 | Biological process | arterial endothelial cell differentiation |
| GO_0003184 | Biological process | pulmonary valve morphogenesis |
| GO_0003186 | Biological process | tricuspid valve morphogenesis |
| GO_0010667 | Biological process | negative regulation of cardiac muscle cell apoptotic process |
| GO_0050767 | Biological process | regulation of neurogenesis |
| GO_0036304 | Biological process | umbilical cord morphogenesis |
| GO_0003222 | Biological process | ventricular trabecula myocardium morphogenesis |
| GO_0045746 | Biological process | negative regulation of Notch signaling pathway |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0010460 | Biological process | positive regulation of heart rate |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0060977 | Biological process | coronary vasculature morphogenesis |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0017053 | Cellular component | transcription repressor complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0000987 | Molecular function | cis-regulatory region sequence-specific DNA binding |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0046983 | Molecular function | protein dimerization activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0042826 | Molecular function | histone deacetylase binding |
| Gene name | HEY2 |
| Protein name | Hairy/enhancer-of-split related with YRPW motif protein 2 (Cardiovascular helix-loop-helix factor 1) (hCHF1) (Class B basic helix-loop-helix protein 32) (bHLHb32) (HES-related repressor protein 2) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HRT-2) (hHRT2) (Protein gridlock homolog) Hes related family bHLH transcription factor with YRPW motif 2 |
| Synonyms | HERP CHF1 BHLHB32 HERP1 GRL HRT2 |
| Description | FUNCTION: Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. . |
| Accessions | ENST00000368365.5 ENST00000368364.4 Q9UBP5 Q5TF93 |
