ATOH8 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ATOH8 at tissue level.

III. Associated gene sets

GO_0010629Biological processnegative regulation of gene expression
GO_0045603Biological processpositive regulation of endothelial cell differentiation
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0060391Biological processpositive regulation of SMAD protein signal transduction
GO_0035148Biological processtube formation
GO_0001704Biological processformation of primary germ layer
GO_0001937Biological processnegative regulation of endothelial cell proliferation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0051450Biological processmyoblast proliferation
GO_0030154Biological processcell differentiation
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0009653Biological processanatomical structure morphogenesis
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0007399Biological processnervous system development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0070888Molecular functionE-box binding
GO_0046983Molecular functionprotein dimerization activity

IV. Literature review

[source]
Gene nameATOH8
Protein nameTranscription factor ATOH8 (Class A basic helix-loop-helix protein 21) (bHLHa21) (Helix-loop-helix protein hATH-6) (hATH6) (Protein atonal homolog 8)
SynonymsBHLHA21
ATH6
DescriptionFUNCTION: Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins . Regulates endothelial cell proliferation, migration and tube-like structures formation . Modulates endothelial cell differentiation through NOS3 . May be implicated in specification and differentiation of neuronal cell lineages in the brain (By similarity). May participate in kidney development and may be involved in podocyte differentiation (By similarity). During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (By similarity). During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (By similarity). Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex . Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (By similarity). .

AccessionsQ96SQ7
ENST00000306279.4 [Q96SQ7-1]