CPNE1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	24 studies	26% ± 8%	Explore
fibroblast	15 studies	23% ± 7%	Explore
B cell	14 studies	23% ± 7%	Explore
endothelial cell	14 studies	25% ± 8%	Explore
CD8-positive, alpha-beta T cell	13 studies	22% ± 6%	Explore
T cell	12 studies	20% ± 4%	Explore
regulatory T cell	12 studies	20% ± 4%	Explore
gamma-delta T cell	12 studies	24% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	29% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	26% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	23% ± 9%	Explore
CD4-positive, alpha-beta T cell	10 studies	22% ± 6%	Explore
mature NK T cell	10 studies	23% ± 8%	Explore
memory B cell	10 studies	19% ± 3%	Explore
smooth muscle cell	9 studies	20% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	20% ± 4%	Explore
pericyte	8 studies	23% ± 6%	Explore
naive B cell	8 studies	20% ± 4%	Explore
epithelial cell	7 studies	33% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	24% ± 9%	Explore
myofibroblast cell	6 studies	23% ± 4%	Explore
mucosal invariant T cell	6 studies	22% ± 3%	Explore
plasmacytoid dendritic cell	6 studies	25% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	27% ± 7%	Explore
oligodendrocyte precursor cell	6 studies	23% ± 6%	Explore
hematopoietic precursor cell	5 studies	31% ± 12%	Explore
conventional dendritic cell	5 studies	33% ± 16%	Explore
connective tissue cell	5 studies	25% ± 7%	Explore
glutamatergic neuron	5 studies	39% ± 19%	Explore
hematopoietic stem cell	5 studies	22% ± 5%	Explore
precursor B cell	5 studies	27% ± 10%	Explore
pro-B cell	5 studies	30% ± 2%	Explore
innate lymphoid cell	5 studies	22% ± 4%	Explore
neuron	5 studies	26% ± 13%	Explore
basal cell	5 studies	30% ± 12%	Explore
non-classical monocyte	4 studies	33% ± 12%	Explore
classical monocyte	4 studies	28% ± 11%	Explore
myeloid cell	4 studies	23% ± 7%	Explore
immature B cell	4 studies	23% ± 5%	Explore
type I pneumocyte	4 studies	23% ± 4%	Explore
ciliated cell	4 studies	25% ± 6%	Explore
astrocyte	4 studies	27% ± 6%	Explore
abnormal cell	4 studies	25% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	23% ± 3%	Explore
leukocyte	3 studies	20% ± 4%	Explore
neural crest cell	3 studies	20% ± 2%	Explore
lymphocyte	3 studies	25% ± 8%	Explore
macrophage	3 studies	24% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	18% ± 3%	Explore
GABAergic neuron	3 studies	43% ± 4%	Explore
dendritic cell	3 studies	43% ± 19%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	23% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	30% ± 11%	Explore
transit amplifying cell	3 studies	22% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	17% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	10 studies	25% ± 10%	Explore
lung	5 studies	25% ± 6%	Explore
brain	5 studies	35% ± 13%	Explore
liver	4 studies	25% ± 7%	Explore
placenta	3 studies	18% ± 1%	Explore
bone marrow	3 studies	20% ± 3%	Explore
intestine	3 studies	23% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5771.74	1445 / 1445	100%	120.11	183 / 183
stomach	100%	4408.10	359 / 359	100%	164.99	286 / 286
thymus	100%	7504.68	653 / 653	100%	116.65	604 / 605
bladder	100%	6974.24	21 / 21	100%	172.98	503 / 504
skin	100%	6636.69	1809 / 1809	100%	134.48	470 / 472
ovary	100%	7199.89	180 / 180	99%	141.55	427 / 430
pancreas	100%	3071.55	327 / 328	99%	103.55	177 / 178
adrenal gland	100%	5319.76	258 / 258	99%	77.31	228 / 230
uterus	100%	8380.52	170 / 170	99%	151.44	455 / 459
intestine	100%	6544.97	966 / 966	99%	167.57	522 / 527
lung	100%	6808.04	578 / 578	99%	116.97	1144 / 1155
prostate	100%	7223.84	245 / 245	99%	77.51	495 / 502
breast	100%	6456.59	459 / 459	98%	109.48	1100 / 1118
brain	98%	3094.78	2598 / 2642	100%	85.74	703 / 705
kidney	100%	4956.91	89 / 89	97%	67.48	870 / 901
liver	100%	2818.92	225 / 226	94%	59.97	381 / 406
adipose	100%	6136.05	1204 / 1204	0%	0	0 / 0
blood vessel	100%	6608.48	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	118.76	80 / 80
lymph node	0%	0	0 / 0	100%	123.71	29 / 29
spleen	100%	9349.06	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	142.37	45 / 45
ureter	0%	0	0 / 0	100%	96.69	1 / 1
peripheral blood	100%	8365.77	926 / 929	0%	0	0 / 0
heart	99%	2937.84	850 / 861	0%	0	0 / 0
muscle	98%	2546.78	787 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1903265	Biological process	positive regulation of tumor necrosis factor-mediated signaling pathway
GO_0010629	Biological process	negative regulation of gene expression
GO_0071277	Biological process	cellular response to calcium ion
GO_1901223	Biological process	negative regulation of non-canonical NF-kappaB signal transduction
GO_0016192	Biological process	vesicle-mediated transport
GO_0006508	Biological process	proteolysis
GO_0043392	Biological process	negative regulation of DNA binding
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_1990138	Biological process	neuron projection extension
GO_0043122	Biological process	regulation of canonical NF-kappaB signal transduction
GO_0045666	Biological process	positive regulation of neuron differentiation
GO_0006629	Biological process	lipid metabolic process
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0035577	Cellular component	azurophil granule membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0031965	Cellular component	nuclear membrane
GO_0005634	Cellular component	nucleus
GO_0004175	Molecular function	endopeptidase activity
GO_0005544	Molecular function	calcium-dependent phospholipid binding
GO_0042802	Molecular function	identical protein binding
GO_0001786	Molecular function	phosphatidylserine binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding
GO_0051059	Molecular function	NF-kappaB binding

IV. Literature review

[source]

Gene name	CPNE1
Protein name	Copine 1 Copine 1 (HCG38213, isoform CRA_b) Copine-1 (Chromobindin 17) (Copine I)
Synonyms	hCG_38213 CPN1
Description	FUNCTION: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes . Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner . Exhibits calcium-dependent phospholipid binding properties . Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner . May recruit target proteins to the cell membrane in a calcium-dependent manner . May function in membrane trafficking . Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit . Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL . .
Accessions	ENST00000416778.5 Q5JX54 Q5JX45 ENST00000430570.5 Q99829 ENST00000440240.5 ENST00000412056.5 E7EV27 Q5JX44 ENST00000439669.5 ENST00000414664.5 Q5JX61 ENST00000437100.5 ENST00000434795.5 ENST00000352393.8 ENST00000420363.5 Q5JX55 ENST00000397442.5 ENST00000437340.5 ENST00000458038.5 Q5JX56 ENST00000317677.9 E7ENH5 B0QZ18 ENST00000435747.2 ENST00000397443.7 H0Y524 ENST00000439806.6 F2Z2V0 Q5JX59 Q5JX53 Q5JX57 A6PVH9 Q5JX58 ENST00000415920.5 ENST00000414711.5 ENST00000401607.6 Q5JX52 Q5JX60

CPNE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review