DIP2A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	27 studies	28% ± 10%	Explore
endothelial cell	16 studies	29% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	32% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	25% ± 6%	Explore
CD8-positive, alpha-beta T cell	13 studies	23% ± 5%	Explore
macrophage	13 studies	31% ± 13%	Explore
microglial cell	12 studies	46% ± 12%	Explore
oligodendrocyte	11 studies	38% ± 13%	Explore
oligodendrocyte precursor cell	10 studies	30% ± 13%	Explore
astrocyte	9 studies	29% ± 11%	Explore
mucosal invariant T cell	9 studies	21% ± 6%	Explore
myeloid cell	9 studies	26% ± 9%	Explore
gamma-delta T cell	9 studies	20% ± 4%	Explore
T cell	8 studies	21% ± 6%	Explore
CD4-positive, alpha-beta T cell	8 studies	23% ± 6%	Explore
mature NK T cell	8 studies	24% ± 7%	Explore
GABAergic neuron	8 studies	43% ± 22%	Explore
glutamatergic neuron	8 studies	38% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	23% ± 5%	Explore
retinal rod cell	7 studies	38% ± 20%	Explore
regulatory T cell	7 studies	17% ± 2%	Explore
neuron	6 studies	35% ± 16%	Explore
interneuron	6 studies	46% ± 21%	Explore
epithelial cell	6 studies	30% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	20% ± 3%	Explore
ciliated cell	5 studies	20% ± 3%	Explore
cardiac muscle cell	5 studies	23% ± 4%	Explore
dendritic cell	5 studies	18% ± 2%	Explore
endothelial cell of lymphatic vessel	5 studies	33% ± 6%	Explore
fibroblast	5 studies	21% ± 5%	Explore
smooth muscle cell	5 studies	17% ± 2%	Explore
amacrine cell	4 studies	29% ± 18%	Explore
lymphocyte	4 studies	36% ± 11%	Explore
retinal cone cell	4 studies	28% ± 11%	Explore
monocyte	4 studies	21% ± 5%	Explore
plasmacytoid dendritic cell	4 studies	19% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	22% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	23% ± 3%	Explore
non-classical monocyte	3 studies	17% ± 2%	Explore
GABAergic interneuron	3 studies	32% ± 8%	Explore
retinal ganglion cell	3 studies	21% ± 5%	Explore
adipocyte	3 studies	23% ± 3%	Explore
glycinergic amacrine cell	3 studies	27% ± 8%	Explore
innate lymphoid cell	3 studies	20% ± 3%	Explore
abnormal cell	3 studies	23% ± 9%	Explore
pericyte	3 studies	20% ± 5%	Explore
type I pneumocyte	3 studies	21% ± 4%	Explore
goblet cell	3 studies	38% ± 27%	Explore
transit amplifying cell	3 studies	34% ± 24%	Explore
brush cell	3 studies	17% ± 0%	Explore
mast cell	3 studies	22% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	35% ± 19%	Explore
eye	5 studies	38% ± 13%	Explore
peripheral blood	4 studies	18% ± 1%	Explore
adipose	4 studies	19% ± 1%	Explore
lung	3 studies	23% ± 4%	Explore
heart	3 studies	21% ± 3%	Explore
intestine	3 studies	16% ± 0%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3743.60	1445 / 1445	100%	11.85	183 / 183
prostate	100%	4476.13	245 / 245	100%	20.03	502 / 502
breast	100%	3970.25	459 / 459	100%	11.52	1116 / 1118
intestine	100%	4091.37	966 / 966	100%	8.93	525 / 527
bladder	100%	3598.71	21 / 21	100%	9.45	502 / 504
lung	100%	4370.93	578 / 578	99%	9.66	1149 / 1155
uterus	100%	4554.49	170 / 170	99%	10.66	456 / 459
thymus	100%	3945.90	653 / 653	99%	8.62	601 / 605
stomach	100%	2825.87	359 / 359	99%	9.32	284 / 286
skin	100%	3963.06	1809 / 1809	99%	9.69	468 / 472
brain	99%	3189.61	2623 / 2642	100%	14.79	703 / 705
pancreas	100%	2410.85	328 / 328	99%	9.27	176 / 178
kidney	100%	2628.81	89 / 89	98%	8.96	885 / 901
adrenal gland	100%	3739.36	258 / 258	97%	8.28	222 / 230
ovary	100%	5140.27	180 / 180	95%	7.10	410 / 430
liver	99%	1391.47	224 / 226	74%	3.44	302 / 406
adipose	100%	3935.76	1204 / 1204	0%	0	0 / 0
spleen	100%	5445.46	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	9.85	45 / 45
ureter	0%	0	0 / 0	100%	4.48	1 / 1
blood vessel	100%	2853.73	1332 / 1335	0%	0	0 / 0
heart	100%	2923.98	859 / 861	0%	0	0 / 0
muscle	99%	2115.42	798 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	7.45	28 / 29
eye	0%	0	0 / 0	89%	7.42	71 / 80
peripheral blood	87%	2075.18	804 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_2000758	Biological process	positive regulation of peptidyl-lysine acetylation
GO_0006085	Biological process	acetyl-CoA biosynthetic process
GO_0010629	Biological process	negative regulation of gene expression
GO_0060997	Biological process	dendritic spine morphogenesis
GO_0009986	Cellular component	cell surface
GO_0043197	Cellular component	dendritic spine
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0003987	Molecular function	acetate-CoA ligase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	DIP2A
Protein name	Disco-interacting protein 2 homolog A (DIP2 homolog A) (EC 6.2.1.1) Disco interacting protein 2 homolog A
Synonyms	DIP2 KIAA0184 C21orf106
Description	FUNCTION: Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes . .
Accessions	ENST00000457905.7 [Q14689-4] Q14689 ENST00000466639.5 [Q14689-3] A0A494C143 ENST00000435722.7 [Q14689-2] ENST00000400274.5 [Q14689-6] ENST00000417564.3 [Q14689-1] ENST00000651436.1

DIP2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review