WWP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051224Biological processnegative regulation of protein transport
GO_0006366Biological processtranscription by RNA polymerase II
GO_0016567Biological processprotein ubiquitination
GO_0042391Biological processregulation of membrane potential
GO_0032410Biological processnegative regulation of transporter activity
GO_0010629Biological processnegative regulation of gene expression
GO_0051865Biological processprotein autoubiquitination
GO_1901016Biological processregulation of potassium ion transmembrane transporter activity
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0034765Biological processregulation of monoatomic ion transmembrane transport
GO_0046718Biological processsymbiont entry into host cell
GO_0036211Biological processprotein modification process
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0006858Biological processextracellular transport
GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000151Cellular componentubiquitin ligase complex
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWWP2
Protein nameNEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
WW domain containing E3 ubiquitin protein ligase 2
Synonyms
DescriptionFUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. .

AccessionsENST00000563659.5
H3BRX8
ENST00000359154.7 [O00308-1]
ENST00000569620.5
O00308
ENST00000569174.5 [O00308-4]
H3BS79
H3BPJ8
ENST00000561780.5
ENST00000356003.6 [O00308-2]
ENST00000568684.1 [O00308-3]