Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 8 studies | 22% ± 4% | |
| capillary endothelial cell | 3 studies | 24% ± 10% | |
| endothelial cell of artery | 3 studies | 28% ± 5% | |
| fibroblast | 3 studies | 24% ± 7% | |
| endothelial cell of vascular tree | 3 studies | 24% ± 6% |
Insufficient scRNA-seq data for expression of MSX1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 85% | 376.81 | 2248 / 2642 | 99% | 29.47 | 699 / 705 |
| adrenal gland | 100% | 517.51 | 257 / 258 | 76% | 23.44 | 175 / 230 |
| prostate | 94% | 546.53 | 231 / 245 | 78% | 6.83 | 393 / 502 |
| skin | 91% | 655.49 | 1642 / 1809 | 72% | 11.05 | 342 / 472 |
| breast | 99% | 1172.00 | 456 / 459 | 63% | 5.53 | 706 / 1118 |
| uterus | 99% | 1974.22 | 169 / 170 | 61% | 44.49 | 279 / 459 |
| ovary | 73% | 270.34 | 131 / 180 | 73% | 42.73 | 316 / 430 |
| bladder | 86% | 1043.00 | 18 / 21 | 54% | 9.30 | 272 / 504 |
| thymus | 100% | 920.41 | 650 / 653 | 35% | 2.33 | 211 / 605 |
| esophagus | 52% | 185.25 | 753 / 1445 | 70% | 8.41 | 128 / 183 |
| lung | 87% | 374.84 | 504 / 578 | 32% | 3.82 | 370 / 1155 |
| intestine | 33% | 88.21 | 320 / 966 | 76% | 10.73 | 402 / 527 |
| stomach | 34% | 110.85 | 122 / 359 | 72% | 10.55 | 206 / 286 |
| pancreas | 28% | 61.52 | 92 / 328 | 75% | 7.31 | 133 / 178 |
| adipose | 100% | 1652.57 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| kidney | 45% | 110.44 | 40 / 89 | 54% | 5.15 | 487 / 901 |
| spleen | 96% | 411.34 | 232 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 94% | 725.64 | 1257 / 1335 | 0% | 0 | 0 / 0 |
| heart | 84% | 325.69 | 720 / 861 | 0% | 0 | 0 / 0 |
| muscle | 48% | 107.79 | 389 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 24% | 2.59 | 7 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 22% | 2.13 | 10 / 45 |
| liver | 1% | 2.84 | 3 / 226 | 20% | 2.26 | 81 / 406 |
| peripheral blood | 16% | 197.23 | 150 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.12 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042475 | Biological process | odontogenesis of dentin-containing tooth |
| GO_0042481 | Biological process | regulation of odontogenesis |
| GO_0006366 | Biological process | transcription by RNA polymerase II |
| GO_0003161 | Biological process | cardiac conduction system development |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0003198 | Biological process | epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO_0060349 | Biological process | bone morphogenesis |
| GO_0035880 | Biological process | embryonic nail plate morphogenesis |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0042482 | Biological process | positive regulation of odontogenesis |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0030900 | Biological process | forebrain development |
| GO_1901330 | Biological process | negative regulation of odontoblast differentiation |
| GO_1902255 | Biological process | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| GO_0048839 | Biological process | inner ear development |
| GO_0061311 | Biological process | cell surface receptor signaling pathway involved in heart development |
| GO_0097152 | Biological process | mesenchymal cell apoptotic process |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0035115 | Biological process | embryonic forelimb morphogenesis |
| GO_0035116 | Biological process | embryonic hindlimb morphogenesis |
| GO_0090427 | Biological process | activation of meiosis |
| GO_0060536 | Biological process | cartilage morphogenesis |
| GO_0043517 | Biological process | positive regulation of DNA damage response, signal transduction by p53 class mediator |
| GO_0043584 | Biological process | nose development |
| GO_0023019 | Biological process | signal transduction involved in regulation of gene expression |
| GO_0030509 | Biological process | BMP signaling pathway |
| GO_0061180 | Biological process | mammary gland epithelium development |
| GO_0060021 | Biological process | roof of mouth development |
| GO_0048598 | Biological process | embryonic morphogenesis |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0050821 | Biological process | protein stabilization |
| GO_0034504 | Biological process | protein localization to nucleus |
| GO_0010463 | Biological process | mesenchymal cell proliferation |
| GO_0030513 | Biological process | positive regulation of BMP signaling pathway |
| GO_0051154 | Biological process | negative regulation of striated muscle cell differentiation |
| GO_0007517 | Biological process | muscle organ development |
| GO_0009952 | Biological process | anterior/posterior pattern specification |
| GO_0000902 | Biological process | cell morphogenesis |
| GO_0042474 | Biological process | middle ear morphogenesis |
| GO_0048863 | Biological process | stem cell differentiation |
| GO_2001055 | Biological process | positive regulation of mesenchymal cell apoptotic process |
| GO_0060325 | Biological process | face morphogenesis |
| GO_0030901 | Biological process | midbrain development |
| GO_0045787 | Biological process | positive regulation of cell cycle |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0030308 | Biological process | negative regulation of cell growth |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0034399 | Cellular component | nuclear periphery |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0000987 | Molecular function | cis-regulatory region sequence-specific DNA binding |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0002039 | Molecular function | p53 binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | MSX1 |
| Protein name | Homeobox protein MSX-1 (Msh homeobox 1-like protein) Homeobox protein MSX-1 (Homeobox protein Hox-7) (Msh homeobox 1-like protein) |
| Synonyms | HOX7 |
| Description | FUNCTION: Acts as a transcriptional repressor (By similarity). Capable of transcription autoinactivation (By similarity). Binds to the consensus sequence 5'-C/GTAAT-3' in downstream activin regulatory elements (DARE) in the gene promoter, thereby repressing the transcription of CGA/alpha-GSU and GNRHR (By similarity). Represses transcription of myoblast differentiation factors (By similarity). Binds to core enhancer regions in target gene promoters of myoblast differentiation factors with binding specificity facilitated by interaction with PIAS1 (By similarity). Recruits histone H3 methyltransferases such as EHMT2/G9a to gene promoter regions which leads to inhibition of myoblast differentiation via transcriptional repression of differentiation factors (By similarity). Regulates, in a stage-specific manner, a developmental program of gene expression in the fetal tooth bud that controls odontoblast differentiation and proliferation of dental mesenchymal cells (By similarity). At the bud stage, required for mesenchymal molar tooth bud development via facilitating reciprocal signaling between dental epithelial and mesenchymal cells (By similarity). May also regulate expression of Wnt antagonists such as DKK2 and SFPR2 in the developing tooth mesenchyme (By similarity). Required for BMP4 expression in dental mesenchyme cells (By similarity). Also, in response to BMP4, required for BMP4 expression in neighboring dental epithelial cells (By similarity). Required for maximal FGF4-induced expression of SDC1 in dental mesenchyme cells (By similarity). Also in response to SDC1, required for SDC1 expression in neighboring dental epithelial cells (By similarity). At the early bell stage, acts to drive proliferation of dental mesenchyme cells, however during the late bell stage acts as an homeostatic regulator of the cell cycle (By similarity). Regulates proliferation and inhibits premature mesenchymal odontogenesis during the bell stage via inhibition of the Wnt signaling component CTNNB1 and subsequent repression of the odontoblast differentiation factors BMP2, BMP4, LEF1, ALPL and BGLAP/OCN (By similarity). Additionally, required for correct development and fusion of the palatal shelves and embryonic mandibular formation (By similarity). Plays a role in embryonic bone formation of the middle ear, skull and nasal bones (By similarity). Required for correct formation and thickness of the nail plate (By similarity). May play a role in limb-pattern formation (By similarity). . |
| Accessions | E9KXY2 E9KXS9 E9KXU7 E9KY15 E9KXT2 E9KXU4 E9KXV2 E9KXW3 E9KXS6 E9KXX7 E9KXU8 E9KY10 E9KXZ5 E9KXW9 E9KXZ8 E9KXV1 E9KXW0 E9KXU6 E9KXT8 E9KXZ7 E9KY19 E9KXT4 E9KXY6 P28360 E9KXZ1 E9KXU5 E9KXW6 E9KY04 E9KXX3 E9KY08 E9KXX5 E9KXT1 E9KXU0 E9KY14 E9KXY8 E9KXX9 E9KXT9 E9KY09 E9KXV0 E9KXW8 E9KXY9 E9KXT0 E9KXU9 E9KY12 E9KXU2 E9KXV3 E9KXW2 E9KY11 E9KY13 E9KXW7 E9KY07 ENST00000382723.5 E9KXY7 E9KY03 E9KXW1 E9KY16 E9KXW5 E9KXZ2 E9KXT3 E9KY06 E9KXT5 E9KXU3 E9KY17 E9KXS8 E9KXZ3 E9KXZ9 E9KXU1 E9KXX8 E9KXX2 E9KXY0 E9KXY5 E9KY18 E9KXV4 E9KXX0 E9KXV5 E9KXX4 E9KXY1 E9KXZ0 E9KXT7 E9KXV8 E9KY00 E9KXX6 E9KY02 E9KXS7 E9KXZ4 E9KXX1 E9KY05 E9KXV7 E9KXW4 E9KXZ6 E9KXV6 E9KXY3 E9KXT6 E9KY01 E9KXV9 E9KXY4 |
