PPP2CB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042542Biological processresponse to hydrogen peroxide
GO_0006470Biological processprotein dephosphorylation
GO_0000278Biological processmitotic cell cycle
GO_0010629Biological processnegative regulation of gene expression
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0010288Biological processresponse to lead ion
GO_0035970Biological processpeptidyl-threonine dephosphorylation
GO_1904528Biological processpositive regulation of microtubule binding
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0046580Biological processnegative regulation of Ras protein signal transduction
GO_0008637Biological processapoptotic mitochondrial changes
GO_0070262Biological processpeptidyl-serine dephosphorylation
GO_0046677Biological processresponse to antibiotic
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000775Cellular componentchromosome, centromeric region
GO_0000922Cellular componentspindle pole
GO_0090443Cellular componentFAR/SIN/STRIPAK complex
GO_0005829Cellular componentcytosol
GO_0000159Cellular componentprotein phosphatase type 2A complex
GO_0005634Cellular componentnucleus
GO_0017018Molecular functionmyosin phosphatase activity
GO_0046872Molecular functionmetal ion binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0048156Molecular functiontau protein binding
GO_0004722Molecular functionprotein serine/threonine phosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePPP2CB
Protein nameSerine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16)
Protein phosphatase 2 catalytic subunit beta
protein-serine/threonine phosphatase (EC 3.1.3.16)
Serine/threonine-protein phosphatase (EC 3.1.3.16)
Synonyms
DescriptionFUNCTION: Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. .

AccessionsENST00000520056.1
E5RJX4
E5RHC1
P62714
ENST00000523023.1
ENST00000520334.5
H0YBN9
ENST00000221138.9
H0YC23
ENST00000518564.1
E5RFI3
ENST00000518243.5