NOCT report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NOCT at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0006739Biological processNADP metabolic process
GO_0045995Biological processregulation of embryonic development
GO_0000290Biological processdeadenylation-dependent decapping of nuclear-transcribed mRNA
GO_0010629Biological processnegative regulation of gene expression
GO_0033962Biological processP-body assembly
GO_0048255Biological processmRNA stabilization
GO_0032922Biological processcircadian regulation of gene expression
GO_0042752Biological processregulation of circadian rhythm
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0032496Biological processresponse to lipopolysaccharide
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0000932Cellular componentP-body
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019178Molecular functionNADP phosphatase activity
GO_0003729Molecular functionmRNA binding
GO_0102757Molecular functionNADPH phosphatase activity
GO_0046872Molecular functionmetal ion binding
GO_0000175Molecular function3'-5'-RNA exonuclease activity
GO_0004535Molecular functionpoly(A)-specific ribonuclease activity

IV. Literature review

[source]
Gene nameNOCT
Protein nameNocturnin (EC 3.1.3.108) (Carbon catabolite repression 4-like protein)
CCR4 carbon catabolite repression 4-like (S. cerevisiae), isoform CRA_b (CCRN4L protein) (Nocturnin)
SynonymsCCRN4L
hCG_1735627
CCR4
NOC
DescriptionFUNCTION: Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH . Shows a small preference for NADPH over NADP(+) . Represses translation and promotes degradation of target mRNA molecules . Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity). .

AccessionsENST00000630479.1
ENST00000280614.4
Q8WTX0
Q9UK39