AURKA | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AURKA at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	95%	341.38	341 / 359	99%	58.00	282 / 286
skin	96%	1010.62	1731 / 1809	98%	38.51	461 / 472
ovary	94%	719.66	170 / 180	98%	35.51	423 / 430
intestine	90%	386.98	868 / 966	98%	57.54	514 / 527
esophagus	83%	286.48	1206 / 1445	99%	45.74	181 / 183
bladder	86%	104.29	18 / 21	96%	44.16	483 / 504
lung	89%	188.11	515 / 578	92%	34.96	1062 / 1155
breast	81%	98.24	373 / 459	93%	33.08	1038 / 1118
liver	87%	255.38	196 / 226	79%	18.89	321 / 406
uterus	62%	63.95	105 / 170	98%	49.16	450 / 459
adrenal gland	98%	209.95	252 / 258	43%	9.36	99 / 230
kidney	93%	188.49	83 / 89	33%	4.58	296 / 901
pancreas	46%	48.43	151 / 328	76%	15.39	136 / 178
brain	73%	78.66	1931 / 2642	39%	8.06	278 / 705
lymph node	0%	0	0 / 0	100%	47.24	29 / 29
tonsil	0%	0	0 / 0	100%	48.79	45 / 45
ureter	0%	0	0 / 0	100%	10.73	1 / 1
spleen	100%	494.78	240 / 241	0%	0	0 / 0
muscle	99%	427.09	794 / 803	0%	0	0 / 0
thymus	80%	95.88	523 / 653	17%	4.55	100 / 605
heart	92%	265.20	788 / 861	0%	0	0 / 0
prostate	73%	82.97	178 / 245	16%	2.12	82 / 502
peripheral blood	84%	1017.57	784 / 929	0%	0	0 / 0
adipose	83%	112.35	1002 / 1204	0%	0	0 / 0
blood vessel	47%	49.69	624 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	45%	5.20	36 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0018105	Biological process	peptidyl-serine phosphorylation
GO_0009948	Biological process	anterior/posterior axis specification
GO_0090141	Biological process	positive regulation of mitochondrial fission
GO_0000278	Biological process	mitotic cell cycle
GO_0010629	Biological process	negative regulation of gene expression
GO_0007052	Biological process	mitotic spindle organization
GO_0046605	Biological process	regulation of centrosome cycle
GO_1900195	Biological process	positive regulation of oocyte maturation
GO_0032436	Biological process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0051642	Biological process	centrosome localization
GO_0007057	Biological process	spindle assembly involved in female meiosis I
GO_0061523	Biological process	cilium disassembly
GO_0071539	Biological process	protein localization to centrosome
GO_0051301	Biological process	cell division
GO_0010389	Biological process	regulation of G2/M transition of mitotic cell cycle
GO_0007100	Biological process	mitotic centrosome separation
GO_0006338	Biological process	chromatin remodeling
GO_0032465	Biological process	regulation of cytokinesis
GO_0031647	Biological process	regulation of protein stability
GO_0045931	Biological process	positive regulation of mitotic cell cycle
GO_0097421	Biological process	liver regeneration
GO_0043066	Biological process	negative regulation of apoptotic process
GO_1901796	Biological process	regulation of signal transduction by p53 class mediator
GO_0006915	Biological process	apoptotic process
GO_0000086	Biological process	G2/M transition of mitotic cell cycle
GO_1990138	Biological process	neuron projection extension
GO_0006468	Biological process	protein phosphorylation
GO_0046777	Biological process	protein autophosphorylation
GO_0032091	Biological process	negative regulation of protein binding
GO_0009611	Biological process	response to wounding
GO_0045840	Biological process	positive regulation of mitotic nuclear division
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0007051	Biological process	spindle organization
GO_0098978	Cellular component	glutamatergic synapse
GO_0097431	Cellular component	mitotic spindle pole
GO_0005876	Cellular component	spindle microtubule
GO_0030496	Cellular component	midbody
GO_0042585	Cellular component	germinal vesicle
GO_0072686	Cellular component	mitotic spindle
GO_0045120	Cellular component	pronucleus
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0031616	Cellular component	spindle pole centrosome
GO_0005813	Cellular component	centrosome
GO_0000776	Cellular component	kinetochore
GO_0043203	Cellular component	axon hillock
GO_0005654	Cellular component	nucleoplasm
GO_0032133	Cellular component	chromosome passenger complex
GO_0005814	Cellular component	centriole
GO_0051233	Cellular component	spindle midzone
GO_0005829	Cellular component	cytosol
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0014069	Cellular component	postsynaptic density
GO_0072687	Cellular component	meiotic spindle
GO_0036064	Cellular component	ciliary basal body
GO_0005819	Cellular component	spindle
GO_0016323	Cellular component	basolateral plasma membrane
GO_0005634	Cellular component	nucleus
GO_0140677	Molecular function	molecular function activator activity
GO_0004712	Molecular function	protein serine/threonine/tyrosine kinase activity
GO_0106310	Molecular function	protein serine kinase activity
GO_0019901	Molecular function	protein kinase binding
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0004672	Molecular function	protein kinase activity
GO_0035175	Molecular function	histone H3S10 kinase activity
GO_0005524	Molecular function	ATP binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	AURKA
Protein name	Aurora kinase (EC 2.7.11.1) Aurora kinase A Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Synonyms	STK15 IAK1 AURA AIK AIRK1 BTAK STK6 AYK1 ARK1
Description	FUNCTION: Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression . Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis . Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase . Required for initial activation of CDK1 at centrosomes . Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 . Regulates KIF2A tubulin depolymerase activity . Important for microtubule formation and/or stabilization . Required for normal axon formation . Plays a role in microtubule remodeling during neurite extension . Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 . Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity . Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin . Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 . .
Accessions	ENST00000422322.5 ENST00000371356.6 A3KFJ0 ENST00000395911.5 ENST00000395907.5 ENST00000395913.7 A3KFJ2 ENST00000420474.5 ENST00000441357.5 O14965 Q5QPD2 ENST00000395914.5 ENST00000451915.1 ENST00000347343.6 Q5QPD1 Q5QPD4 ENST00000395915.8 ENST00000312783.10 A3KFJ1 ENST00000456249.5

AURKA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review