YY1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0045995Biological processregulation of embryonic development
GO_0010629Biological processnegative regulation of gene expression
GO_0034644Biological processcellular response to UV
GO_0048593Biological processcamera-type eye morphogenesis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010225Biological processresponse to UV-C
GO_0045739Biological processpositive regulation of DNA repair
GO_0071707Biological processimmunoglobulin heavy chain V-D-J recombination
GO_0006282Biological processregulation of DNA repair
GO_0010628Biological processpositive regulation of gene expression
GO_0006974Biological processDNA damage response
GO_1902894Biological processnegative regulation of miRNA transcription
GO_0060382Biological processregulation of DNA strand elongation
GO_1904507Biological processpositive regulation of telomere maintenance in response to DNA damage
GO_0071347Biological processcellular response to interleukin-1
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0061052Biological processnegative regulation of cell growth involved in cardiac muscle cell development
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0030183Biological processB cell differentiation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0034696Biological processresponse to prostaglandin F
GO_0000723Biological processtelomere maintenance
GO_0009952Biological processanterior/posterior pattern specification
GO_0033044Biological processregulation of chromosome organization
GO_0032688Biological processnegative regulation of interferon-beta production
GO_0006275Biological processregulation of DNA replication
GO_0006403Biological processRNA localization
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0031519Cellular componentPcG protein complex
GO_0005654Cellular componentnucleoplasm
GO_0005677Cellular componentchromatin silencing complex
GO_0016363Cellular componentnuclear matrix
GO_0000785Cellular componentchromatin
GO_0031011Cellular componentIno80 complex
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0046332Molecular functionSMAD binding
GO_0000400Molecular functionfour-way junction DNA binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0001217Molecular functionDNA-binding transcription repressor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameYY1
Protein nameTranscriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1)
YY1 transcription factor
SynonymsINO80S
DescriptionFUNCTION: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site . Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity . The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes . Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression . For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence . Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression . Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions . May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed . Involved in DNA repair . In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation . .; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. .

AccessionsENST00000553625.5
ENST00000704485.1
ENST00000262238.10
A0A494C032
ENST00000554804.1
A0A994J726
H0YJU4
ENST00000554371.1
G3V3M8
P25490
ENST00000651219.1
H0YJV7