OVOL2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of OVOL2 at tissue level.

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0008283Biological processcell population proliferation
GO_0060392Biological processnegative regulation of SMAD protein signal transduction
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0010629Biological processnegative regulation of gene expression
GO_0001755Biological processneural crest cell migration
GO_0001947Biological processheart looping
GO_0060347Biological processheart trabecula formation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010628Biological processpositive regulation of gene expression
GO_0009913Biological processepidermal cell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_2000647Biological processnegative regulation of stem cell proliferation
GO_0009953Biological processdorsal/ventral pattern formation
GO_0060214Biological processendocardium formation
GO_0010719Biological processnegative regulation of epithelial to mesenchymal transition
GO_0048557Biological processembryonic digestive tract morphogenesis
GO_0060716Biological processlabyrinthine layer blood vessel development
GO_0001842Biological processneural fold formation
GO_0010837Biological processregulation of keratinocyte proliferation
GO_0045618Biological processpositive regulation of keratinocyte differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682Molecular functionchromatin binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameOVOL2
Protein nameTranscription factor Ovo-like 2 (hOvo2) (Zinc finger protein 339)
SynonymsZNF339
DescriptionFUNCTION: Zinc-finger transcription repressor factor . Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 . Important for the correct development of primordial germ cells in embryos (By similarity). Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Essential for brown/beige adipose tissue-mediated thermogenesis, is necessary for the development of brown adipocytes. In white adipose tissues, limits adipogenesis by blocking CEBPA binding to its transcriptional targets and inhibiting its transcription factor activity (By similarity). .

AccessionsQ9BRP0
ENST00000278780.7 [Q9BRP0-1]