Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 42 studies | 50% ± 20% | |
plasmacytoid dendritic cell | 18 studies | 46% ± 15% | |
fibroblast | 15 studies | 26% ± 10% | |
endothelial cell | 14 studies | 24% ± 11% | |
myeloid cell | 14 studies | 40% ± 17% | |
conventional dendritic cell | 10 studies | 21% ± 6% | |
type II pneumocyte | 9 studies | 33% ± 16% | |
microglial cell | 9 studies | 24% ± 9% | |
pericyte | 8 studies | 24% ± 10% | |
dendritic cell | 8 studies | 33% ± 16% | |
monocyte | 6 studies | 29% ± 15% | |
epithelial cell of proximal tubule | 6 studies | 24% ± 6% | |
smooth muscle cell | 6 studies | 24% ± 6% | |
leukocyte | 5 studies | 30% ± 3% | |
epithelial cell | 5 studies | 42% ± 24% | |
mononuclear phagocyte | 4 studies | 44% ± 13% | |
retinal cone cell | 4 studies | 26% ± 8% | |
endothelial cell of sinusoid | 4 studies | 39% ± 26% | |
type I pneumocyte | 4 studies | 25% ± 8% | |
enterocyte | 4 studies | 22% ± 7% | |
alveolar macrophage | 3 studies | 28% ± 10% | |
pancreatic A cell | 3 studies | 37% ± 13% | |
glomerular endothelial cell | 3 studies | 25% ± 8% | |
abnormal cell | 3 studies | 19% ± 2% | |
extravillous trophoblast | 3 studies | 27% ± 7% | |
placental villous trophoblast | 3 studies | 46% ± 23% | |
basal cell | 3 studies | 20% ± 2% | |
tissue-resident macrophage | 3 studies | 65% ± 16% | |
endothelial cell of vascular tree | 3 studies | 20% ± 3% | |
GABAergic neuron | 3 studies | 39% ± 11% | |
glutamatergic neuron | 3 studies | 33% ± 10% | |
connective tissue cell | 3 studies | 27% ± 12% | |
interneuron | 3 studies | 33% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
stomach | 100% | 3994.53 | 359 / 359 | 100% | 116.05 | 286 / 286 |
esophagus | 100% | 3919.71 | 1444 / 1445 | 100% | 89.15 | 183 / 183 |
lung | 100% | 8462.55 | 578 / 578 | 100% | 159.44 | 1152 / 1155 |
prostate | 100% | 3622.47 | 245 / 245 | 99% | 130.15 | 499 / 502 |
breast | 100% | 5402.39 | 459 / 459 | 99% | 115.42 | 1109 / 1118 |
uterus | 100% | 3019.59 | 170 / 170 | 99% | 111.77 | 455 / 459 |
intestine | 100% | 5190.85 | 966 / 966 | 99% | 117.74 | 522 / 527 |
thymus | 100% | 9500.74 | 653 / 653 | 99% | 114.02 | 599 / 605 |
skin | 100% | 2962.25 | 1807 / 1809 | 99% | 158.92 | 466 / 472 |
bladder | 100% | 6848.90 | 21 / 21 | 98% | 122.38 | 495 / 504 |
ovary | 99% | 3093.32 | 179 / 180 | 98% | 83.61 | 423 / 430 |
kidney | 100% | 9718.78 | 89 / 89 | 98% | 164.31 | 879 / 901 |
liver | 97% | 2685.98 | 220 / 226 | 97% | 71.00 | 393 / 406 |
pancreas | 92% | 1806.81 | 303 / 328 | 99% | 146.25 | 177 / 178 |
brain | 83% | 1614.24 | 2197 / 2642 | 99% | 78.67 | 701 / 705 |
adrenal gland | 98% | 3714.76 | 254 / 258 | 69% | 45.51 | 158 / 230 |
adipose | 100% | 8270.91 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 172.75 | 29 / 29 |
spleen | 100% | 10892.65 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 103.89 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 30.27 | 1 / 1 |
blood vessel | 100% | 7030.94 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 2773.24 | 797 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 4543.34 | 846 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 79.53 | 77 / 80 |
peripheral blood | 27% | 3906.78 | 251 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0003014 | Biological process | renal system process |
GO_0010629 | Biological process | negative regulation of gene expression |
GO_0035729 | Biological process | cellular response to hepatocyte growth factor stimulus |
GO_0090026 | Biological process | positive regulation of monocyte chemotaxis |
GO_0008306 | Biological process | associative learning |
GO_0040015 | Biological process | negative regulation of multicellular organism growth |
GO_0006624 | Biological process | vacuolar protein processing |
GO_0097202 | Biological process | activation of cysteine-type endopeptidase activity |
GO_0010447 | Biological process | response to acidic pH |
GO_0071277 | Biological process | cellular response to calcium ion |
GO_0042359 | Biological process | vitamin D metabolic process |
GO_0045931 | Biological process | positive regulation of mitotic cell cycle |
GO_0097061 | Biological process | dendritic spine organization |
GO_0097264 | Biological process | self proteolysis |
GO_0006508 | Biological process | proteolysis |
GO_2001028 | Biological process | positive regulation of endothelial cell chemotaxis |
GO_1900273 | Biological process | positive regulation of long-term synaptic potentiation |
GO_1901185 | Biological process | negative regulation of ERBB signaling pathway |
GO_0007613 | Biological process | memory |
GO_0019886 | Biological process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0051603 | Biological process | proteolysis involved in protein catabolic process |
GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
GO_1904646 | Biological process | cellular response to amyloid-beta |
GO_0032801 | Biological process | receptor catabolic process |
GO_0051604 | Biological process | protein maturation |
GO_0005576 | Cellular component | extracellular region |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0005764 | Cellular component | lysosome |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005770 | Cellular component | late endosome |
GO_0005737 | Cellular component | cytoplasm |
GO_0043202 | Cellular component | lysosomal lumen |
GO_0036021 | Cellular component | endolysosome lumen |
GO_0045177 | Cellular component | apical part of cell |
GO_0008233 | Molecular function | peptidase activity |
GO_0061133 | Molecular function | endopeptidase activator activity |
GO_0048156 | Molecular function | tau protein binding |
GO_0004197 | Molecular function | cysteine-type endopeptidase activity |
Gene name | LGMN |
Protein name | Legumain Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (AEP) (Protease, cysteine 1) Legumain (EC 3.4.22.34) (Protease, cysteine 1) |
Synonyms | hCG_21254 PRSC1 |
Description | FUNCTION: Has a strict specificity for hydrolysis of asparaginyl bonds . Can also cleave aspartyl bonds slowly, especially under acidic conditions . Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system . Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol (By similarity). Required for normal lysosomal protein degradation in renal proximal tubules (By similarity). Required for normal degradation of internalized EGFR (By similarity). Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). . |
Accessions | G3V4E4 G3V2T4 ENST00000555169.1 ENST00000554189.5 G3V2E9 G3V3Z4 ENST00000554080.5 ENST00000393218.6 [Q99538-1] ENST00000555699.5 [Q99538-3] Q99538 ENST00000557434.5 [Q99538-2] G3V5B2 ENST00000556097.5 Q53XC6 ENST00000553802.5 ENST00000554397.5 ENST00000557609.5 G3V4P5 Q6I9U9 ENST00000553918.1 G3V263 ENST00000334869.9 [Q99538-1] ENST00000554919.5 ENST00000553371.1 H0YJN9 |