LGMN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0003014Biological processrenal system process
GO_0010629Biological processnegative regulation of gene expression
GO_0035729Biological processcellular response to hepatocyte growth factor stimulus
GO_0090026Biological processpositive regulation of monocyte chemotaxis
GO_0008306Biological processassociative learning
GO_0040015Biological processnegative regulation of multicellular organism growth
GO_0006624Biological processvacuolar protein processing
GO_0097202Biological processactivation of cysteine-type endopeptidase activity
GO_0010447Biological processresponse to acidic pH
GO_0071277Biological processcellular response to calcium ion
GO_0042359Biological processvitamin D metabolic process
GO_0045931Biological processpositive regulation of mitotic cell cycle
GO_0097061Biological processdendritic spine organization
GO_0097264Biological processself proteolysis
GO_0006508Biological processproteolysis
GO_2001028Biological processpositive regulation of endothelial cell chemotaxis
GO_1900273Biological processpositive regulation of long-term synaptic potentiation
GO_1901185Biological processnegative regulation of ERBB signaling pathway
GO_0007613Biological processmemory
GO_0019886Biological processantigen processing and presentation of exogenous peptide antigen via MHC class II
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0051603Biological processproteolysis involved in protein catabolic process
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_1904646Biological processcellular response to amyloid-beta
GO_0032801Biological processreceptor catabolic process
GO_0051604Biological processprotein maturation
GO_0005576Cellular componentextracellular region
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005764Cellular componentlysosome
GO_0070062Cellular componentextracellular exosome
GO_0005770Cellular componentlate endosome
GO_0005737Cellular componentcytoplasm
GO_0043202Cellular componentlysosomal lumen
GO_0036021Cellular componentendolysosome lumen
GO_0045177Cellular componentapical part of cell
GO_0008233Molecular functionpeptidase activity
GO_0061133Molecular functionendopeptidase activator activity
GO_0048156Molecular functiontau protein binding
GO_0004197Molecular functioncysteine-type endopeptidase activity

IV. Literature review

[source]
Gene nameLGMN
Protein nameLegumain
Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (AEP) (Protease, cysteine 1)
Legumain (EC 3.4.22.34) (Protease, cysteine 1)
SynonymshCG_21254
PRSC1
DescriptionFUNCTION: Has a strict specificity for hydrolysis of asparaginyl bonds . Can also cleave aspartyl bonds slowly, especially under acidic conditions . Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system . Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol (By similarity). Required for normal lysosomal protein degradation in renal proximal tubules (By similarity). Required for normal degradation of internalized EGFR (By similarity). Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). .

AccessionsG3V4E4
G3V2T4
ENST00000555169.1
ENST00000554189.5
G3V2E9
G3V3Z4
ENST00000554080.5
ENST00000393218.6 [Q99538-1]
ENST00000555699.5 [Q99538-3]
Q99538
ENST00000557434.5 [Q99538-2]
G3V5B2
ENST00000556097.5
Q53XC6
ENST00000553802.5
ENST00000554397.5
ENST00000557609.5
G3V4P5
Q6I9U9
ENST00000553918.1
G3V263
ENST00000334869.9 [Q99538-1]
ENST00000554919.5
ENST00000553371.1
H0YJN9