MAPT | OmnibusX

Name	Number of supported studies	Average coverage
astrocyte	15 studies	42% ± 18%	Explore
oligodendrocyte	13 studies	50% ± 21%	Explore
oligodendrocyte precursor cell	11 studies	47% ± 19%	Explore
glutamatergic neuron	10 studies	65% ± 20%	Explore
GABAergic neuron	9 studies	54% ± 22%	Explore
neuron	9 studies	56% ± 16%	Explore
amacrine cell	8 studies	39% ± 16%	Explore
retina horizontal cell	7 studies	66% ± 9%	Explore
retinal ganglion cell	7 studies	79% ± 17%	Explore
retinal cone cell	6 studies	21% ± 4%	Explore
retinal bipolar neuron	5 studies	54% ± 8%	Explore
interneuron	5 studies	69% ± 19%	Explore
OFF-bipolar cell	5 studies	45% ± 26%	Explore
ON-bipolar cell	5 studies	50% ± 24%	Explore
Mueller cell	5 studies	45% ± 7%	Explore
granule cell	4 studies	58% ± 7%	Explore
GABAergic amacrine cell	4 studies	45% ± 18%	Explore
glycinergic amacrine cell	4 studies	30% ± 14%	Explore
adipocyte	4 studies	20% ± 2%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	51% ± 7%	Explore
endothelial cell	3 studies	53% ± 18%	Explore
microglial cell	3 studies	29% ± 11%	Explore
pericyte	3 studies	32% ± 18%	Explore
rod bipolar cell	3 studies	61% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	53% ± 19%	Explore
eye	8 studies	27% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	23714.88	2639 / 2642	98%	112.40	693 / 705
breast	52%	2088.42	238 / 459	70%	33.76	784 / 1118
kidney	48%	2141.48	43 / 89	59%	13.92	531 / 901
prostate	31%	1006.34	77 / 245	70%	9.44	352 / 502
muscle	100%	12874.42	803 / 803	0%	0	0 / 0
adrenal gland	6%	231.34	16 / 258	68%	31.27	156 / 230
bladder	48%	2643.76	10 / 21	1%	0.31	6 / 504
eye	0%	0	0 / 0	43%	4.64	34 / 80
intestine	33%	1051.04	323 / 966	1%	0.12	5 / 527
skin	19%	459.77	349 / 1809	8%	0.86	40 / 472
heart	21%	646.83	182 / 861	0%	0	0 / 0
adipose	19%	533.36	228 / 1204	0%	0	0 / 0
esophagus	16%	439.23	237 / 1445	1%	0.08	2 / 183
uterus	1%	11.95	1 / 170	5%	0.61	22 / 459
thymus	0%	8.22	2 / 653	5%	0.58	29 / 605
pancreas	0%	0	0 / 328	5%	1.36	9 / 178
stomach	4%	101.88	14 / 359	1%	0.11	3 / 286
liver	0%	0	0 / 226	4%	0.45	17 / 406
lung	0%	3.28	1 / 578	3%	0.29	29 / 1155
blood vessel	2%	50.50	21 / 1335	0%	0	0 / 0
ovary	0%	0	0 / 180	1%	0.08	4 / 430
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1904428	Biological process	negative regulation of tubulin deacetylation
GO_0061564	Biological process	axon development
GO_0048312	Biological process	intracellular distribution of mitochondria
GO_0007267	Biological process	cell-cell signaling
GO_0050848	Biological process	regulation of calcium-mediated signaling
GO_0010917	Biological process	negative regulation of mitochondrial membrane potential
GO_0000226	Biological process	microtubule cytoskeleton organization
GO_0007613	Biological process	memory
GO_0006919	Biological process	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0034063	Biological process	stress granule assembly
GO_0031122	Biological process	cytoplasmic microtubule organization
GO_0010629	Biological process	negative regulation of gene expression
GO_0048143	Biological process	astrocyte activation
GO_0031175	Biological process	neuron projection development
GO_0010288	Biological process	response to lead ion
GO_1900034	Biological process	regulation of cellular response to heat
GO_0016072	Biological process	rRNA metabolic process
GO_0098930	Biological process	axonal transport
GO_0046785	Biological process	microtubule polymerization
GO_0010506	Biological process	regulation of autophagy
GO_0021954	Biological process	central nervous system neuron development
GO_0090140	Biological process	regulation of mitochondrial fission
GO_0032930	Biological process	positive regulation of superoxide anion generation
GO_0090258	Biological process	negative regulation of mitochondrial fission
GO_0070507	Biological process	regulation of microtubule cytoskeleton organization
GO_1903829	Biological process	positive regulation of protein localization
GO_1902988	Biological process	neurofibrillary tangle assembly
GO_0019896	Biological process	axonal transport of mitochondrion
GO_0001774	Biological process	microglial cell activation
GO_1900452	Biological process	regulation of long-term synaptic depression
GO_0031110	Biological process	regulation of microtubule polymerization or depolymerization
GO_0097435	Biological process	supramolecular fiber organization
GO_0033673	Biological process	negative regulation of kinase activity
GO_0051258	Biological process	protein polymerization
GO_1990090	Biological process	cellular response to nerve growth factor stimulus
GO_0050808	Biological process	synapse organization
GO_0031113	Biological process	regulation of microtubule polymerization
GO_1902474	Biological process	positive regulation of protein localization to synapse
GO_0034614	Biological process	cellular response to reactive oxygen species
GO_1905689	Biological process	positive regulation of diacylglycerol kinase activity
GO_0034605	Biological process	cellular response to heat
GO_0045773	Biological process	positive regulation of axon extension
GO_1990416	Biological process	cellular response to brain-derived neurotrophic factor stimulus
GO_0006974	Biological process	DNA damage response
GO_0006475	Biological process	internal protein amino acid acetylation
GO_0072386	Biological process	plus-end-directed organelle transport along microtubule
GO_0031116	Biological process	positive regulation of microtubule polymerization
GO_0048699	Biological process	generation of neurons
GO_1990000	Biological process	amyloid fibril formation
GO_0048167	Biological process	regulation of synaptic plasticity
GO_0033044	Biological process	regulation of chromosome organization
GO_1903748	Biological process	negative regulation of establishment of protein localization to mitochondrion
GO_0045121	Cellular component	membrane raft
GO_0036477	Cellular component	somatodendritic compartment
GO_0043025	Cellular component	neuronal cell body
GO_0043005	Cellular component	neuron projection
GO_0030673	Cellular component	axolemma
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0005634	Cellular component	nucleus
GO_0005576	Cellular component	extracellular region
GO_0097418	Cellular component	neurofibrillary tangle
GO_0030425	Cellular component	dendrite
GO_0034399	Cellular component	nuclear periphery
GO_0005886	Cellular component	plasma membrane
GO_0005874	Cellular component	microtubule
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0044304	Cellular component	main axon
GO_0005737	Cellular component	cytoplasm
GO_0030424	Cellular component	axon
GO_0097386	Cellular component	glial cell projection
GO_1904115	Cellular component	axon cytoplasm
GO_0043197	Cellular component	dendritic spine
GO_0036464	Cellular component	cytoplasmic ribonucleoprotein granule
GO_0016607	Cellular component	nuclear speck
GO_0005829	Cellular component	cytosol
GO_0030426	Cellular component	growth cone
GO_0044297	Cellular component	cell body
GO_0045298	Cellular component	tubulin complex
GO_0051879	Molecular function	Hsp90 protein binding
GO_0034452	Molecular function	dynactin binding
GO_0071813	Molecular function	lipoprotein particle binding
GO_0042802	Molecular function	identical protein binding
GO_1902936	Molecular function	phosphatidylinositol bisphosphate binding
GO_0051721	Molecular function	protein phosphatase 2A binding
GO_0043565	Molecular function	sequence-specific DNA binding
GO_0003690	Molecular function	double-stranded DNA binding
GO_0099077	Molecular function	histone-dependent DNA binding
GO_0099609	Molecular function	microtubule lateral binding
GO_0003779	Molecular function	actin binding
GO_0017124	Molecular function	SH3 domain binding
GO_0019899	Molecular function	enzyme binding
GO_0035091	Molecular function	phosphatidylinositol binding
GO_0034185	Molecular function	apolipoprotein binding
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0003680	Molecular function	minor groove of adenine-thymine-rich DNA binding
GO_0030674	Molecular function	protein-macromolecule adaptor activity
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0003677	Molecular function	DNA binding
GO_0003697	Molecular function	single-stranded DNA binding
GO_0019901	Molecular function	protein kinase binding
GO_0008017	Molecular function	microtubule binding

IV. Literature review

[source]

Gene name	MAPT
Protein name	Microtubule-associated protein tau Mutant microtubule-associated protein tau Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Microtubule-associated protein
Synonyms	TAU MAPTL MTBT1
Description	FUNCTION: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity . The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both . Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. .
Accessions	A0A7I2PLE3 ENST00000703922.1 [P10636-7] ENST00000628393.2 [P10636-2] ENST00000622728.1 [P10636-6] A0A0G2JPD5 T1SGS4 ENST00000703923.1 [P10636-6] ENST00000613360.4 [P10636-7] A0A7I2PJZ2 ENST00000633801.1 ENST00000626571.2 [P10636-6] ENST00000632122.1 ENST00000621329.4 [P10636-8] ENST00000618029.3 ENST00000632500.1 [P10636-7] ENST00000703924.1 [P10636-7] ENST00000633054.1 ENST00000633415.1 ENST00000680542.1 [P10636-7] ENST00000344290.10 ENST00000535772.6 [P10636-4] ENST00000620070.4 [P10636-8] ENST00000625688.1 ENST00000622106.2 [P10636-6] ENST00000351559.10 [P10636-8] ENST00000574436.5 [P10636-8] ENST00000633047.1 [P10636-2] ENST00000620818.4 [P10636-5] A0A0G2JQJ7 ENST00000680674.1 ENST00000620981.4 [P10636-5] A0A0G2JS76 ENST00000618825.4 P10636 ENST00000571987.5 [P10636-1] ENST00000431008.7 [P10636-5] ENST00000634049.1 [P10636-8] ENST00000415613.6 [P10636-9] ENST00000612872.4 [P10636-7] A0A0G2JMX7 I3L2Z2 ENST00000631447.1 [P10636-5] ENST00000629368.2 I3L170 ENST00000703978.1 [P10636-8] ENST00000420682.7 [P10636-7] ENST00000627711.2 ENST00000571311.5 ENST00000446361.7 [P10636-6] ENST00000334239.12 [P10636-2] ENST00000262410.10 A0A7P0T936

MAPT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review