ROBO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0035904Biological processaorta development
GO_0003148Biological processoutflow tract septum morphogenesis
GO_0050772Biological processpositive regulation of axonogenesis
GO_0003272Biological processendocardial cushion formation
GO_0010629Biological processnegative regulation of gene expression
GO_0035385Biological processRoundabout signaling pathway
GO_0070100Biological processnegative regulation of chemokine-mediated signaling pathway
GO_0002042Biological processcell migration involved in sprouting angiogenesis
GO_0010628Biological processpositive regulation of gene expression
GO_0003180Biological processaortic valve morphogenesis
GO_0050925Biological processnegative regulation of negative chemotaxis
GO_0007155Biological processcell adhesion
GO_1900748Biological processpositive regulation of vascular endothelial growth factor signaling pathway
GO_0033600Biological processnegative regulation of mammary gland epithelial cell proliferation
GO_0043406Biological processpositive regulation of MAP kinase activity
GO_0021836Biological processchemorepulsion involved in postnatal olfactory bulb interneuron migration
GO_0003129Biological processheart induction
GO_0007156Biological processhomophilic cell adhesion via plasma membrane adhesion molecules
GO_0060412Biological processventricular septum morphogenesis
GO_0030336Biological processnegative regulation of cell migration
GO_0003184Biological processpulmonary valve morphogenesis
GO_0030949Biological processpositive regulation of vascular endothelial growth factor receptor signaling pathway
GO_0045747Biological processpositive regulation of Notch signaling pathway
GO_0016199Biological processaxon midline choice point recognition
GO_0035025Biological processpositive regulation of Rho protein signal transduction
GO_0007399Biological processnervous system development
GO_0005886Cellular componentplasma membrane
GO_0043005Cellular componentneuron projection
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0009986Cellular componentcell surface
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0008046Molecular functionaxon guidance receptor activity
GO_0042802Molecular functionidentical protein binding
GO_0030275Molecular functionLRR domain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameROBO1
Protein nameRoundabout guidance receptor 1
ROBO1 protein
Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1)
SynonymsDUTT1
DescriptionFUNCTION: Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development . Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 . In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA . May be required for lung development (By similarity). .

AccessionsENST00000436010.6
H7C545
ENST00000472273.1
F8WEV8
Q9Y6N7
ENST00000492990.1
Q1RMC8
ENST00000464233.6 [Q9Y6N7-1]
ENST00000495273.5 [Q9Y6N7-5]
H7C4Y7
A0A0A0MSX4
ENST00000495961.1
A0A087WZ85
Q2M1J3
ENST00000467549.5 [Q9Y6N7-6]
ENST00000618846.4