Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 17 studies | 37% ± 15% | |
astrocyte | 16 studies | 35% ± 18% | |
oligodendrocyte | 15 studies | 54% ± 18% | |
oligodendrocyte precursor cell | 15 studies | 48% ± 18% | |
glutamatergic neuron | 12 studies | 58% ± 20% | |
GABAergic neuron | 11 studies | 67% ± 17% | |
endothelial cell | 11 studies | 39% ± 15% | |
pericyte | 10 studies | 24% ± 9% | |
myofibroblast cell | 7 studies | 29% ± 17% | |
adipocyte | 7 studies | 36% ± 8% | |
smooth muscle cell | 7 studies | 33% ± 9% | |
interneuron | 6 studies | 65% ± 28% | |
microglial cell | 6 studies | 45% ± 22% | |
neuron | 5 studies | 62% ± 29% | |
amacrine cell | 5 studies | 27% ± 12% | |
mesothelial cell | 5 studies | 33% ± 15% | |
type I pneumocyte | 5 studies | 19% ± 2% | |
epithelial cell | 4 studies | 29% ± 15% | |
granule cell | 4 studies | 37% ± 10% | |
retina horizontal cell | 4 studies | 33% ± 19% | |
connective tissue cell | 4 studies | 30% ± 12% | |
basal cell | 4 studies | 40% ± 21% | |
macrophage | 3 studies | 35% ± 14% | |
GABAergic interneuron | 3 studies | 75% ± 2% | |
progenitor cell | 3 studies | 47% ± 12% | |
GABAergic amacrine cell | 3 studies | 53% ± 7% | |
glycinergic amacrine cell | 3 studies | 36% ± 10% | |
retinal ganglion cell | 3 studies | 45% ± 18% | |
Mueller cell | 3 studies | 34% ± 19% | |
retinal pigment epithelial cell | 3 studies | 36% ± 24% | |
club cell | 3 studies | 33% ± 16% | |
hepatocyte | 3 studies | 39% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 2382.12 | 2636 / 2642 | 98% | 43.69 | 694 / 705 |
uterus | 100% | 2046.96 | 170 / 170 | 91% | 22.29 | 418 / 459 |
esophagus | 99% | 1681.49 | 1433 / 1445 | 91% | 19.25 | 166 / 183 |
skin | 100% | 4279.74 | 1809 / 1809 | 89% | 28.42 | 421 / 472 |
adrenal gland | 100% | 2686.71 | 258 / 258 | 88% | 16.04 | 202 / 230 |
prostate | 100% | 2873.41 | 245 / 245 | 88% | 12.23 | 440 / 502 |
lung | 100% | 2097.17 | 577 / 578 | 88% | 17.02 | 1014 / 1155 |
breast | 100% | 1847.83 | 457 / 459 | 85% | 13.17 | 954 / 1118 |
thymus | 99% | 1233.34 | 649 / 653 | 74% | 9.19 | 450 / 605 |
bladder | 95% | 2105.19 | 20 / 21 | 70% | 12.61 | 355 / 504 |
intestine | 96% | 2056.29 | 928 / 966 | 67% | 7.97 | 355 / 527 |
ovary | 100% | 2693.94 | 180 / 180 | 61% | 6.22 | 264 / 430 |
kidney | 89% | 809.63 | 79 / 89 | 63% | 7.12 | 567 / 901 |
stomach | 69% | 833.80 | 249 / 359 | 77% | 9.89 | 219 / 286 |
adipose | 100% | 2221.24 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2390.27 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1286.13 | 240 / 241 | 0% | 0 | 0 / 0 |
pancreas | 10% | 65.03 | 34 / 328 | 86% | 11.93 | 153 / 178 |
tonsil | 0% | 0 | 0 / 0 | 91% | 35.65 | 41 / 45 |
liver | 15% | 91.37 | 35 / 226 | 75% | 18.63 | 303 / 406 |
heart | 82% | 1170.74 | 705 / 861 | 0% | 0 | 0 / 0 |
muscle | 66% | 512.67 | 533 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 59% | 6.11 | 17 / 29 |
eye | 0% | 0 | 0 / 0 | 35% | 5.41 | 28 / 80 |
peripheral blood | 9% | 177.25 | 80 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006919 | Biological process | activation of cysteine-type endopeptidase activity involved in apoptotic process |
GO_0035904 | Biological process | aorta development |
GO_0003148 | Biological process | outflow tract septum morphogenesis |
GO_0050772 | Biological process | positive regulation of axonogenesis |
GO_0003272 | Biological process | endocardial cushion formation |
GO_0010629 | Biological process | negative regulation of gene expression |
GO_0035385 | Biological process | Roundabout signaling pathway |
GO_0070100 | Biological process | negative regulation of chemokine-mediated signaling pathway |
GO_0002042 | Biological process | cell migration involved in sprouting angiogenesis |
GO_0010628 | Biological process | positive regulation of gene expression |
GO_0003180 | Biological process | aortic valve morphogenesis |
GO_0050925 | Biological process | negative regulation of negative chemotaxis |
GO_0007155 | Biological process | cell adhesion |
GO_1900748 | Biological process | positive regulation of vascular endothelial growth factor signaling pathway |
GO_0033600 | Biological process | negative regulation of mammary gland epithelial cell proliferation |
GO_0043406 | Biological process | positive regulation of MAP kinase activity |
GO_0021836 | Biological process | chemorepulsion involved in postnatal olfactory bulb interneuron migration |
GO_0003129 | Biological process | heart induction |
GO_0007156 | Biological process | homophilic cell adhesion via plasma membrane adhesion molecules |
GO_0060412 | Biological process | ventricular septum morphogenesis |
GO_0030336 | Biological process | negative regulation of cell migration |
GO_0003184 | Biological process | pulmonary valve morphogenesis |
GO_0030949 | Biological process | positive regulation of vascular endothelial growth factor receptor signaling pathway |
GO_0045747 | Biological process | positive regulation of Notch signaling pathway |
GO_0016199 | Biological process | axon midline choice point recognition |
GO_0035025 | Biological process | positive regulation of Rho protein signal transduction |
GO_0007399 | Biological process | nervous system development |
GO_0005886 | Cellular component | plasma membrane |
GO_0043005 | Cellular component | neuron projection |
GO_0033116 | Cellular component | endoplasmic reticulum-Golgi intermediate compartment membrane |
GO_0009986 | Cellular component | cell surface |
GO_0005737 | Cellular component | cytoplasm |
GO_0030424 | Cellular component | axon |
GO_0008046 | Molecular function | axon guidance receptor activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0030275 | Molecular function | LRR domain binding |
GO_0005515 | Molecular function | protein binding |
Gene name | ROBO1 |
Protein name | Roundabout guidance receptor 1 ROBO1 protein Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1) |
Synonyms | DUTT1 |
Description | FUNCTION: Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development . Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 . In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA . May be required for lung development (By similarity). . |
Accessions | ENST00000436010.6 H7C545 ENST00000472273.1 F8WEV8 Q9Y6N7 ENST00000492990.1 Q1RMC8 ENST00000464233.6 [Q9Y6N7-1] ENST00000495273.5 [Q9Y6N7-5] H7C4Y7 A0A0A0MSX4 ENST00000495961.1 A0A087WZ85 Q2M1J3 ENST00000467549.5 [Q9Y6N7-6] ENST00000618846.4 |